caa a22 4500 606183000 CHVBK 20210128100819.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s00405-014-3233-x doi (NATIONALLICENCE)springer-10.1007/s00405-014-3233-x The effect of thyme honey nasal spray on chronic rhinosinusitis: a double-blind randomized controlled clinical trial [Elektronische Daten] [Farnaz Hashemian, Neda Baghbanian, Zahra Majd, Mohammad-Reza Rouini, Javaneh Jahanshahi, Farshad Hashemian] Chronic rhinosinusitis is a common disease which causes persisting inflammatory conditions of one or more sinuses. This study was designed to evaluate the effect of thyme honey nasal spray as an adjunctive medication on chronic rhinosinusitis after functional endoscopic sinus surgery. This was a randomized, placebo controlled, double-blind clinical study. 64 patients with chronic rhinosinusitis undergoing functional endoscopic sinus surgery were enrolled in this study. Patients were randomized and blinded to receive either placebo or thyme honey nasal spray in addition to the standard regimen postoperatively. Patients were visited on postoperative days 7, 30 and 60. The sino-nasal outcome test, endoscopic grading system and sinus CT-scan were scored before operation and on the day 60 after surgery. 54 patients completed the study. Significant improvement was observed in both treatment groups. There were no significant changes in SNOT-22, endoscopy and CT-scan scores between the two study groups. However, a greater reduction in endoscopic scores was shown in thyme honey group. The incidence of adverse effects was not significantly different between the groups, but synechiae formation and epistaxis were lower in treatment group. Thyme honey nasal spray seems to be a low-priced potential adjuvant remedy with excellent safety profile, to reduce inflammation and polyp formation and also fostering mucosal healing for patients suffering from chronic rhinosinusitis. However, further studies are recommended. Springer-Verlag Berlin Heidelberg, 2014 FESS nationallicence Chronic rhinosinusitis nationallicence Thyme honey nationallicence Polyposis nationallicence Samter's nationallicence Hashemian Farnaz Department of Otolaryngology, Hamadan University of Medical Sciences, Hamadan, Iran aut Baghbanian Neda Department of Otolaryngology, Hamadan University of Medical Sciences, Hamadan, Iran aut Majd Zahra Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran aut Rouini Mohammad-Reza Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran aut Jahanshahi Javaneh Department of Otolaryngology, Hamadan University of Medical Sciences, Hamadan, Iran aut Hashemian Farshad Department of Clinical Pharmacy, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/6(2015-06-01), 1429-1435 0937-4477 272:6<1429 2015 272 405 https://doi.org/10.1007/s00405-014-3233-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-3233-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hashemian Farnaz Department of Otolaryngology, Hamadan University of Medical Sciences, Hamadan, Iran aut NATIONALLICENCE 700 1- Baghbanian Neda Department of Otolaryngology, Hamadan University of Medical Sciences, Hamadan, Iran aut NATIONALLICENCE 700 1- Majd Zahra Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran aut NATIONALLICENCE 700 1- Rouini Mohammad-Reza Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran aut NATIONALLICENCE 700 1- Jahanshahi Javaneh Department of Otolaryngology, Hamadan University of Medical Sciences, Hamadan, Iran aut NATIONALLICENCE 700 1- Hashemian Farshad Department of Clinical Pharmacy, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/6(2015-06-01), 1429-1435 0937-4477 272:6<1429 2015 272 405