caa a22 4500 606183019 CHVBK 20210128100819.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s00405-015-3535-7 doi (NATIONALLICENCE)springer-10.1007/s00405-015-3535-7 Clinical and biochemical characteristics of patients with Fusobacterium necrophorum -positive acute tonsillitis [Elektronische Daten] [Ann Kjærulff, Marianne Thomsen, Therese Ovesen, Tejs Klug] Fusobacterium necrophorum (FN) is the predominant pathogen in peritonsillar abscesses, which is a relatively frequent complication of acute tonsillitis. The study aimed to explore if FN is a significant pathogen in acute tonsillitis, examine the prevalence of FN in acute tonsillitis patients, and describe the clinical and biochemical characteristics of FN-positive patients. A 6-month prospective study was conducted in a Danish general practice with eight physicians. One hundred acute tonsillitis patients and 100 healthy controls aged 15-40years were included in the study. The prevalence of FN was (non-significantly) higher among acute tonsillitis patients (16%) compared to healthy individuals (9%) (P=0.199). This trend was border significant for patients aged 15-29years (24 vs 9%) (P=0.050). Significantly, more FN-positive patients were men (75%) compared to patients growing other bacteria (17%) or mixed oral flora (27%) (P<0.001). Centor scores, individual clinical symptoms, and infection markers were similar between patient growing FN and mixed oral flora. FN is possibly a significant and prevalent pathogen in acute tonsillitis among teenagers and young adults. Patients with FN-positive acute tonsillitis do not seem to be more clinically or biochemically affected than patients without growth of bacterial pathogens. Springer-Verlag Berlin Heidelberg, 2015 Acute tonsillitis nationallicence Fusobacterium necrophorum nationallicence Clinical characteristics nationallicence Biochemical parameters nationallicence C-reactive protein, procalcitonin nationallicence Kjærulff Ann Department of Otorhinolaryngology, Head and Neck Surgery, Aarhus University Hospital, Noerrebrogade 44, 8000, Aarhus C, Denmark aut Thomsen Marianne Department of Clinical Microbiology, Aarhus University Hospital, Brendstrupgårdsvej 100, 8200, Aarhus N, Denmark aut Ovesen Therese Department of Otorhinolaryngology, Head and Neck Surgery, Aarhus University Hospital, Noerrebrogade 44, 8000, Aarhus C, Denmark aut Klug Tejs Department of Otorhinolaryngology, Head and Neck Surgery, Aarhus University Hospital, Noerrebrogade 44, 8000, Aarhus C, Denmark aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/6(2015-06-01), 1457-1463 0937-4477 272:6<1457 2015 272 405 https://doi.org/10.1007/s00405-015-3535-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-015-3535-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kjærulff Ann Department of Otorhinolaryngology, Head and Neck Surgery, Aarhus University Hospital, Noerrebrogade 44, 8000, Aarhus C, Denmark aut NATIONALLICENCE 700 1- Thomsen Marianne Department of Clinical Microbiology, Aarhus University Hospital, Brendstrupgårdsvej 100, 8200, Aarhus N, Denmark aut NATIONALLICENCE 700 1- Ovesen Therese Department of Otorhinolaryngology, Head and Neck Surgery, Aarhus University Hospital, Noerrebrogade 44, 8000, Aarhus C, Denmark aut NATIONALLICENCE 700 1- Klug Tejs Department of Otorhinolaryngology, Head and Neck Surgery, Aarhus University Hospital, Noerrebrogade 44, 8000, Aarhus C, Denmark aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/6(2015-06-01), 1457-1463 0937-4477 272:6<1457 2015 272 405