caa a22 4500 606183027 CHVBK 20210128100819.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s00405-014-3230-0 doi (NATIONALLICENCE)springer-10.1007/s00405-014-3230-0 Vivostat®: an autologous fibrin sealant as useful adjunct in endoscopic transnasal CSF-leak repair [Elektronische Daten] [Peter Tomazic, Stefan Edlinger, Verena Gellner, Wolfgang Koele, Claus Gerstenberger, Hannes Braun, Michael Mokry, Heinz Stammberger] The benefit of fibrin glue for reduction of postoperative CSF-leaks after endoscopic skull base surgery is not clearly evident in literature. However, its use is supposed to be beneficial in fixing grafting material. As of today there is no specific data available for otolaryngological procedures. A retrospective data analysis at a tertiary care referral center on 73 patients treated endoscopically transnasally for CSF-leaks at the ENT-department Graz between 2009 and 2012was performed. Primary closure rate between conventional fibrin glue and autologous fibrin glue were analyzed. The Vivostat® system was used in 33 CSF-leak closures and in 40 cases conventional fibrin glue was used. Comparing the two methods the primary closure rate using the autologous Vivostat® system was 75.8 and 85.0% with conventional fibrin glue. The secondary closure the rates were 90.9% with Vivostat® 92.5% with conventional fibrin glue. The Vivosat® system is a useful adjunct in endoscopic CSF-leak closure. Its advantages over conventional fibrin glue are its application system for fixation of grafting material particularly in underlay techniques. Despite this advantage it cannot replace grafting material or is a substitute for proper endoscopic closurewhich is reflected by the closure rates. Springer-Verlag Berlin Heidelberg, 2014 Autologous fibrin glue nationallicence Vivostat nationallicence CSF-leak repair nationallicence Closure rates nationallicence Endoscopic nationallicence Tomazic Peter Department of General Otorhinolaryngology, Head and Neck Surgery, ENT-University Hospital Graz, Medical University Graz, Auenbruggerplatz 26/28, 8036, Graz, Austria aut Edlinger Stefan Department of General Otorhinolaryngology, Head and Neck Surgery, ENT-University Hospital Graz, Medical University Graz, Auenbruggerplatz 26/28, 8036, Graz, Austria aut Gellner Verena Department of Neurosurgery, Medical University Graz, Graz, Austria aut Koele Wolfgang Department of General Otorhinolaryngology, Head and Neck Surgery, ENT-University Hospital Graz, Medical University Graz, Auenbruggerplatz 26/28, 8036, Graz, Austria aut Gerstenberger Claus Department of General Otorhinolaryngology, Head and Neck Surgery, ENT-University Hospital Graz, Medical University Graz, Auenbruggerplatz 26/28, 8036, Graz, Austria aut Braun Hannes Department of General Otorhinolaryngology, Head and Neck Surgery, ENT-University Hospital Graz, Medical University Graz, Auenbruggerplatz 26/28, 8036, Graz, Austria aut Mokry Michael Department of Neurosurgery, Medical University Graz, Graz, Austria aut Stammberger Heinz Department of General Otorhinolaryngology, Head and Neck Surgery, ENT-University Hospital Graz, Medical University Graz, Auenbruggerplatz 26/28, 8036, Graz, Austria aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/6(2015-06-01), 1423-1427 0937-4477 272:6<1423 2015 272 405 https://doi.org/10.1007/s00405-014-3230-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-3230-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tomazic Peter Department of General Otorhinolaryngology, Head and Neck Surgery, ENT-University Hospital Graz, Medical University Graz, Auenbruggerplatz 26/28, 8036, Graz, Austria aut NATIONALLICENCE 700 1- Edlinger Stefan Department of General Otorhinolaryngology, Head and Neck Surgery, ENT-University Hospital Graz, Medical University Graz, Auenbruggerplatz 26/28, 8036, Graz, Austria aut NATIONALLICENCE 700 1- Gellner Verena Department of Neurosurgery, Medical University Graz, Graz, Austria aut NATIONALLICENCE 700 1- Koele Wolfgang Department of General Otorhinolaryngology, Head and Neck Surgery, ENT-University Hospital Graz, Medical University Graz, Auenbruggerplatz 26/28, 8036, Graz, Austria aut NATIONALLICENCE 700 1- Gerstenberger Claus Department of General Otorhinolaryngology, Head and Neck Surgery, ENT-University Hospital Graz, Medical University Graz, Auenbruggerplatz 26/28, 8036, Graz, Austria aut NATIONALLICENCE 700 1- Braun Hannes Department of General Otorhinolaryngology, Head and Neck Surgery, ENT-University Hospital Graz, Medical University Graz, Auenbruggerplatz 26/28, 8036, Graz, Austria aut NATIONALLICENCE 700 1- Mokry Michael Department of Neurosurgery, Medical University Graz, Graz, Austria aut NATIONALLICENCE 700 1- Stammberger Heinz Department of General Otorhinolaryngology, Head and Neck Surgery, ENT-University Hospital Graz, Medical University Graz, Auenbruggerplatz 26/28, 8036, Graz, Austria aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/6(2015-06-01), 1423-1427 0937-4477 272:6<1423 2015 272 405