caa a22 4500 606183108 CHVBK 20210128100819.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s00405-015-3537-5 doi (NATIONALLICENCE)springer-10.1007/s00405-015-3537-5 Relationship between severity of obstructive sleep apnea and adverse cardiac outcomes in non-diabetic patients presenting with myocardial infarction [Elektronische Daten] [Liang-Ping Zhao, Kelvin Loh, Germaine Loo, See-Meng Khoo, Liang Shen, Chi-Hang Lee] Previous studies that have reported an association between obstructive sleep apnea and adverse cardiac events were confounded by a high prevalence of diabetes mellitus. We investigated the relationship between obstructive sleep apnea and the occurrence of major adverse cardiac events in non-diabetic patients who presented with ST-segment elevation myocardial infarction. A total of 41 patients who underwent overnight sleep screening within 5days after admission for myocardial infarction from January 2007 to December 2008 were identified. Major adverse cardiac events—defined as a composite of cardiac death, non-fatal myocardial infarction, hospitalization for angina and congestive heart failure at 5-year follow-up—were determined. The patients were divided into two groups: those who experienced major adverse cardiac events and those who did not. In the overall cohort, the prevalence of obesity was 4.9%. A total of 13 (31.7%) patients had major adverse cardiac events. The mean apnea-hypopnea index was 25.4±20.3. The group that experienced major adverse cardiac events had a higher apnea-hypopnea index than the group that did not (36.1±21.0 vs 20.4±18.2; P=0.016). After adjusting for the resolution of ST-segment elevation and the use of a glycoprotein IIb/IIIa inhibitor, logistic regression analysis revealed that the apnea-hypopnea index remained an independent predictor of major adverse cardiac events (odds ratio 1.044; 95% confidence interval 1.003-1.086; P=0.033). In non-diabetic patients, the severity of obstructive sleep apnea was associated with the occurrence of major adverse cardiac events at 5-year follow-up after ST-segment elevation myocardial infarction. Springer-Verlag Berlin Heidelberg, 2015 Sleep breathing disorder nationallicence Coronary revascularization nationallicence Myocardial infarction nationallicence Risk factor nationallicence Outcomes nationallicence Zhao Liang-Ping Department of Cardiology, National University Heart Centre, Singapore, 1E Kent Ridge Road, NUHS Tower Block Level 9, 119228, Singapore, Singapore aut Loh Kelvin Department of Cardiology, National University Heart Centre, Singapore, 1E Kent Ridge Road, NUHS Tower Block Level 9, 119228, Singapore, Singapore aut Loo Germaine Department of Cardiology, National University Heart Centre, Singapore, 1E Kent Ridge Road, NUHS Tower Block Level 9, 119228, Singapore, Singapore aut Khoo See-Meng University Medical Cluster, National University Health System, Singapore, Singapore aut Shen Liang Biostatistics Unit, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore, Singapore aut Lee Chi-Hang Department of Cardiology, National University Heart Centre, Singapore, 1E Kent Ridge Road, NUHS Tower Block Level 9, 119228, Singapore, Singapore aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/9(2015-09-01), 2527-2533 0937-4477 272:9<2527 2015 272 405 https://doi.org/10.1007/s00405-015-3537-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-015-3537-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zhao Liang-Ping Department of Cardiology, National University Heart Centre, Singapore, 1E Kent Ridge Road, NUHS Tower Block Level 9, 119228, Singapore, Singapore aut NATIONALLICENCE 700 1- Loh Kelvin Department of Cardiology, National University Heart Centre, Singapore, 1E Kent Ridge Road, NUHS Tower Block Level 9, 119228, Singapore, Singapore aut NATIONALLICENCE 700 1- Loo Germaine Department of Cardiology, National University Heart Centre, Singapore, 1E Kent Ridge Road, NUHS Tower Block Level 9, 119228, Singapore, Singapore aut NATIONALLICENCE 700 1- Khoo See-Meng University Medical Cluster, National University Health System, Singapore, Singapore aut NATIONALLICENCE 700 1- Shen Liang Biostatistics Unit, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore, Singapore aut NATIONALLICENCE 700 1- Lee Chi-Hang Department of Cardiology, National University Heart Centre, Singapore, 1E Kent Ridge Road, NUHS Tower Block Level 9, 119228, Singapore, Singapore aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/9(2015-09-01), 2527-2533 0937-4477 272:9<2527 2015 272 405