caa a22 4500 606183280 CHVBK 20210128100820.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s00405-014-3151-y doi (NATIONALLICENCE)springer-10.1007/s00405-014-3151-y Sex-specific association of RANTES gene −403 variant in Meniere's disease [Elektronische Daten] [Nasrin Yazdani, Marzieh Mojbafan, Motahareh Taleba, Parvin Amiri, Farzaneh Nejadian, Mohammadtaghi ashtiani, Mahsa Amoli] Several studies have shown the correlation between RANTES gene and inflammatory disorders; the aim of the present study was to investigate the association between RANTES promoter gene polymorphism and Meniere's disease (MD) in an Iranian population. In this study patients with MD comprising definite MD (N=56) and probable MD (N=15) were selected according to diagnostic criteria of AAO-HNS. The control group (N=101) were healthy normal subjects who did not have a history of ear disease and vertigo. PCR-RFLP for RANTES −403G>A has been performed. We found a protective role for RANTES −403A allele in male group in our population. None of the male patients with MD were carrier of allele A which was significantly different from the presence of allele A in the male control group (AA+GA vs. GG: p=0.0004, OR 0.05, 95% CI 0.001-0.39). This difference was not significant in female group. There was no significant association between RANTES gene polymorphism and the level of hearing loss. our results showed a sex-specific association between RANTES gene polymorphism and MD but more studies are necessary to further assess this association. Springer-Verlag Berlin Heidelberg, 2014 RANTES nationallicence Gene nationallicence Variation nationallicence Meniere's nationallicence Yazdani Nasrin Otorhinolaryngology Research Center, Amir-Alam Hospital, Tehran University of Medical Sciences (TUMS), Tehran, Iran aut Mojbafan Marzieh Department of Molecular Medicine, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran aut Taleba Motahareh Otorhinolaryngology Research Center, Amir-Alam Hospital, Tehran University of Medical Sciences (TUMS), Tehran, Iran aut Amiri Parvin Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran aut Nejadian Farzaneh Otorhinolaryngology Research Center, Amir-Alam Hospital, Tehran University of Medical Sciences (TUMS), Tehran, Iran aut ashtiani Mohammadtaghi Otorhinolaryngology Research Center, Amir-Alam Hospital, Tehran University of Medical Sciences (TUMS), Tehran, Iran aut Amoli Mahsa Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/9(2015-09-01), 2221-2225 0937-4477 272:9<2221 2015 272 405 https://doi.org/10.1007/s00405-014-3151-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-3151-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yazdani Nasrin Otorhinolaryngology Research Center, Amir-Alam Hospital, Tehran University of Medical Sciences (TUMS), Tehran, Iran aut NATIONALLICENCE 700 1- Mojbafan Marzieh Department of Molecular Medicine, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran aut NATIONALLICENCE 700 1- Taleba Motahareh Otorhinolaryngology Research Center, Amir-Alam Hospital, Tehran University of Medical Sciences (TUMS), Tehran, Iran aut NATIONALLICENCE 700 1- Amiri Parvin Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran aut NATIONALLICENCE 700 1- Nejadian Farzaneh Otorhinolaryngology Research Center, Amir-Alam Hospital, Tehran University of Medical Sciences (TUMS), Tehran, Iran aut NATIONALLICENCE 700 1- ashtiani Mohammadtaghi Otorhinolaryngology Research Center, Amir-Alam Hospital, Tehran University of Medical Sciences (TUMS), Tehran, Iran aut NATIONALLICENCE 700 1- Amoli Mahsa Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/9(2015-09-01), 2221-2225 0937-4477 272:9<2221 2015 272 405