caa a22 4500 606183361 CHVBK 20210128100821.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s00405-014-3198-9 doi (NATIONALLICENCE)springer-10.1007/s00405-014-3198-9 Association between the methylenetetrahydrofolate reductase gene C677T polymorphism and sudden sensorineural hearing loss: a meta-analysis [Elektronische Daten] [Jingcheng Shu, Shihua Yin, An-Zhou Tan, Meirong He] A variety of epidemiological studies have evaluated the association between methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism and sudden sensorineural hearing loss (SSNHL), but the results were inconsistent. The aim of this meta-analysis was to clarify more accurately the association of this polymorphism with SSNHL. A systematic literature search of the associated studies up to May 1, 2014, was conducted using the following electronic databases: PubMed, Embase, Medline, and the China National Knowledge Infrastructure. Statistical analyses were performed by STATA12.0 software, with odds ratios (ORs) and their 95% confidence intervals (CIs). Six eligible studies including covering 1,271 objects were identified. A pooled analysis of these studies showed no significant association between C677T polymorphism and risk of SSNHL: T vs. C (OR=1.334, POR=0.105); TT vs. CC (OR=1.580, POR=0.231); CT vs. CC (OR=1.500, POR=0.123); TT vs. CC+CT (OR=1.326, POR=0.293); and TT+CT vs. CC (OR=1.540, POR=0.102). But in subgroup analysis, a significant association was found in European populations (T vs. C, OR=1.542, 95% CI 1.008-2.359, P=0.046; TT vs. CT+CC, OR=1.856, 95% CI 1.245-2.767, P=0.002). There was no significant association in any model in the Asian populations. The present meta-analysis suggests that MTHFR gene C677T polymorphism is significantly associated with increased risk of SSNHL disease in European populations, but no statistically significant association was found between the MTHFR C677T gene mutation and SSNHL in Asian. Further large and well-designed studies are needed to confirm this association. Springer-Verlag Berlin Heidelberg, 2014 Methylenetetrahydrofolate reductase gene nationallicence Polymorphism nationallicence Sudden sensorineural hearing loss nationallicence Meta-analysis nationallicence Shu Jingcheng Department of Otorhinolaryngology-Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, 530021, Nanning, Guangxi Zhuang Autonomous Region, China aut Yin Shihua Department of Otorhinolaryngology-Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, 530021, Nanning, Guangxi Zhuang Autonomous Region, China aut Tan An-Zhou Department of Otorhinolaryngology-Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, 530021, Nanning, Guangxi Zhuang Autonomous Region, China aut He Meirong Department of Obstetrics and Gynecology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/9(2015-09-01), 2267-2274 0937-4477 272:9<2267 2015 272 405 https://doi.org/10.1007/s00405-014-3198-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-3198-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Shu Jingcheng Department of Otorhinolaryngology-Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, 530021, Nanning, Guangxi Zhuang Autonomous Region, China aut NATIONALLICENCE 700 1- Yin Shihua Department of Otorhinolaryngology-Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, 530021, Nanning, Guangxi Zhuang Autonomous Region, China aut NATIONALLICENCE 700 1- Tan An-Zhou Department of Otorhinolaryngology-Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, 530021, Nanning, Guangxi Zhuang Autonomous Region, China aut NATIONALLICENCE 700 1- He Meirong Department of Obstetrics and Gynecology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/9(2015-09-01), 2267-2274 0937-4477 272:9<2267 2015 272 405