caa a22 4500 606183434 CHVBK 20210128100821.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s00405-014-3221-1 doi (NATIONALLICENCE)springer-10.1007/s00405-014-3221-1 Intensity-modulated radiotherapy in definitive oncological treatment of hypopharyngeal squamous cell carcinoma [Elektronische Daten] [Harri Keski-Säntti, Antti Mäkitie, Kauko Saarilahti] Hypopharyngeal squamous cell carcinoma (HSCC) is treated by definitive concomitant chemoradiotherapy at most centres. Intensity-modulated radiotherapy (IMRT) is an advanced computer-controlled high-precision radiotherapy technique that has been used at our institution in the treatment of HSCC since 2002. Our aim was to review the treatment results of IMRT-based chemoradiotherapy (CRT) in patients diagnosed with HSCC. The cohort comprised all patients with previously untreated, biopsy-proven squamous cell carcinoma of the hypopharynx treated by definitive CRT using IMRT between March 2002 and November 2010. All patients were diagnosed M0. Forty-five eligible patients were identified. Six patients were treated by radiotherapy alone and 39 patients received concomitant chemotherapy. All patients had a minimum follow-up of 3years or until death. Complete response was achieved in 29/45 (64%) patients. Salvage surgery was performed on 10/16 patients with incomplete response. The 5-year estimates for overall survival, disease-specific survival, and local control in the whole cohort were 31, 45, and 64%, respectively. Classifications T4 and N2c-N3 were prognostic for worse survival. None of the surviving patients needed permanent tracheotomy or PEG tube. We conclude that survival after IMRT-based CRT remained unsatisfactory with frequent relapses at distant sites. The outcome figures were comparable with those that have been achieved by surgery and postoperative radiotherapy. However, all the surviving patients in the current study cohort could retain their functioning larynx. These results using IMRT-based definitive CRT as the primary option for the treatment of HSCC support its continued usage for the delivery of radiotherapy. Springer-Verlag Berlin Heidelberg, 2014 Head and neck squamous cell carcinoma nationallicence Hypopharyngeal cancer nationallicence Intensity-modulated radiotherapy nationallicence IMRT nationallicence Chemoradiotherapy nationallicence Keski-Säntti Harri Department of Otorhinolaryngology, Head and Neck Surgery, Helsinki University Central Hospital and University of Helsinki, P.O.Box 220, 00029, Helsinki, Finland aut Mäkitie Antti Department of Otorhinolaryngology, Head and Neck Surgery, Helsinki University Central Hospital and University of Helsinki, P.O.Box 220, 00029, Helsinki, Finland aut Saarilahti Kauko Department of Oncology, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/9(2015-09-01), 2489-2495 0937-4477 272:9<2489 2015 272 405 https://doi.org/10.1007/s00405-014-3221-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-3221-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Keski-Säntti Harri Department of Otorhinolaryngology, Head and Neck Surgery, Helsinki University Central Hospital and University of Helsinki, P.O.Box 220, 00029, Helsinki, Finland aut NATIONALLICENCE 700 1- Mäkitie Antti Department of Otorhinolaryngology, Head and Neck Surgery, Helsinki University Central Hospital and University of Helsinki, P.O.Box 220, 00029, Helsinki, Finland aut NATIONALLICENCE 700 1- Saarilahti Kauko Department of Oncology, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/9(2015-09-01), 2489-2495 0937-4477 272:9<2489 2015 272 405