caa a22 4500 606183582 CHVBK 20210128100822.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s00405-014-3141-0 doi (NATIONALLICENCE)springer-10.1007/s00405-014-3141-0 Management of vagal paragangliomas: review of 17 patients [Elektronische Daten] [Ricardo González-Orús Álvarez-Morujo, Miguel Arístegui Ruiz, Carlos Martin Oviedo, Itziar Álvarez Palacios, Bartolomé Scola Yurrita] Vagal paragangliomas are very rare benign vascular tumors of neuroendocrine nature, and are much less frequent than carotid and jugulo-tympanic tumors. The goal of this retrospective study is to review the clinical and genetic findings, surgical treatment, and complications of vagal paragangliomas, as well as to discuss the management options. During the period 1990-2013, 17 patients with vagal paragangliomas were referred to our institution. There were ten patients with isolated tumors, and seven with multicentric paragangliomas. There were nine women and eight men. Mean age of patients was 51.4years. Five cases had a positive family history of paraganglioma (29.4%). Germline mutations of SDH genes were found in six of our patients (35.3%). Many options were considered in the management of vagal paragangliomas. Surgical treatment was performed in 11 young patients (64.7%) using different approaches: in 4 patients the tumor was resected through a transcervical approach; in 3 through a transcervical-transmandibular approach; in 1 it was resected using a transcervical-transmastoid approach, and in 3 a type A infratemporal fossa approach was performed. In all operated cases, the removal of the tumor led to sacrificing of the vagus nerve. Postoperative hypoglossal nerve deficit was reported in 4 cases (36.3%). In six elderly patients (35.3%), we decided to "wait-and-scan” in order to avoid creating greater morbidity than that of the tumor itself. Many factors should be considered in the treatment of vagal paragangliomas: the age and general condition of the patient, the biological behavior of the tumor, tumor size, genetic results, bilaterality, multicentricity, lower cranial nerve function, and of course the potential morbidity of the surgical treatment itself. Rehabilitation and, possibly surgery, are necessary to treat postoperative lower cranial nerve deficits. Springer-Verlag Berlin Heidelberg, 2014 Vagal paraganglioma nationallicence Glomus vagal tumor nationallicence Vagus nerve nationallicence Paraganglioma nationallicence González-Orús Álvarez-Morujo Ricardo Department of Otolaryngology, Head and Neck Surgery, Hospital General Universitario Gregorio Marañón, Doctor Esquerdo St, 46, 28007, Madrid, Spain aut Arístegui Ruiz Miguel Department of Otolaryngology, Head and Neck Surgery, Hospital General Universitario Gregorio Marañón, Doctor Esquerdo St, 46, 28007, Madrid, Spain aut Martin Oviedo Carlos Department of Otolaryngology, Head and Neck Surgery, Hospital General Universitario Gregorio Marañón, Doctor Esquerdo St, 46, 28007, Madrid, Spain aut Álvarez Palacios Itziar Department of Otolaryngology, Head and Neck Surgery, Hospital General Universitario Gregorio Marañón, Doctor Esquerdo St, 46, 28007, Madrid, Spain aut Scola Yurrita Bartolomé Department of Otolaryngology, Head and Neck Surgery, Hospital General Universitario Gregorio Marañón, Doctor Esquerdo St, 46, 28007, Madrid, Spain aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/9(2015-09-01), 2403-2414 0937-4477 272:9<2403 2015 272 405 https://doi.org/10.1007/s00405-014-3141-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-3141-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- González-Orús Álvarez-Morujo Ricardo Department of Otolaryngology, Head and Neck Surgery, Hospital General Universitario Gregorio Marañón, Doctor Esquerdo St, 46, 28007, Madrid, Spain aut NATIONALLICENCE 700 1- Arístegui Ruiz Miguel Department of Otolaryngology, Head and Neck Surgery, Hospital General Universitario Gregorio Marañón, Doctor Esquerdo St, 46, 28007, Madrid, Spain aut NATIONALLICENCE 700 1- Martin Oviedo Carlos Department of Otolaryngology, Head and Neck Surgery, Hospital General Universitario Gregorio Marañón, Doctor Esquerdo St, 46, 28007, Madrid, Spain aut NATIONALLICENCE 700 1- Álvarez Palacios Itziar Department of Otolaryngology, Head and Neck Surgery, Hospital General Universitario Gregorio Marañón, Doctor Esquerdo St, 46, 28007, Madrid, Spain aut NATIONALLICENCE 700 1- Scola Yurrita Bartolomé Department of Otolaryngology, Head and Neck Surgery, Hospital General Universitario Gregorio Marañón, Doctor Esquerdo St, 46, 28007, Madrid, Spain aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/9(2015-09-01), 2403-2414 0937-4477 272:9<2403 2015 272 405