caa a22 4500 606183647 CHVBK 20210128100822.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s00405-014-3361-3 doi (NATIONALLICENCE)springer-10.1007/s00405-014-3361-3 Relationship between biofilms and clinical features in patients with sinus fungal ball [Elektronische Daten] [Xiao Wang, Dong Dong, Jingliang Cheng, Xinjuan Fan, Yulin Zhao] The presence of bacterial biofilms (BBF) and fungal biofilms (FBF) is associated with greater disease severity in chronic rhinosinusitis. However, researches on biofilms in fungal rhinosinusitis are rare. This study investigated the relationship between biofilms and clinical features in patients with sinus fungal ball (SFB). Sixty-four SFB patients undergoing endoscopic sinus surgery and 21 controls were enrolled in this study. Mucosal samples from nasal sinuses were collected for biofilm detection under confocal scanning laser microscopy (CSLM). The general clinical data, Lund-Mackay computed tomography (CT) score, Lund-Kennedy endoscopy score, Global Osteitis Scoring Scale (GOSS) score, Sinonasal Outcome Test (SNOT)-22 score and visual analog scale (VAS) score were recorded. Associations between these parameters and biofilms were assessed. Under CSLM, the positive rates of BBF and FBF were 45.3% (29/64) and 21.9% (14/64), respectively in the SFB group but none in controls. When sub-classified according to biofilm status, the BBF-positive subgroup had significantly higher Lund-Mackay score and GOSS score than the BBF-negative one, but there were no differences in demographic characteristics, health-related quality-of-life and endoscopic inflammatory severity. BBF and FBF coexisted on the sinus mucosa of the patients with SFB. BBF was associated with more severe disease, but the distribution of FBF did not affect the severity of SFB. Springer-Verlag Berlin Heidelberg, 2014 Sinus fungal ball nationallicence Biofilms nationallicence Osteitis nationallicence Confocal scanning laser microscopy nationallicence Wang Xiao Department of Radiology, The First Affiliated Hospital of Zhengzhou University, No. 1 Construction East Road, 450000, Zhengzhou, China aut Dong Dong Department of Rhinology, The First Affiliated Hospital of Zhengzhou University, 450000, Zhengzhou, China aut Cheng Jingliang Department of Radiology, The First Affiliated Hospital of Zhengzhou University, No. 1 Construction East Road, 450000, Zhengzhou, China aut Fan Xinjuan Department of Pathology, The Sixth Affiliated Hospital of Sun Yat-sen University, 450000, Guangzhou, China aut Zhao Yulin Department of Rhinology, The First Affiliated Hospital of Zhengzhou University, 450000, Zhengzhou, China aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/9(2015-09-01), 2363-2369 0937-4477 272:9<2363 2015 272 405 https://doi.org/10.1007/s00405-014-3361-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-3361-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wang Xiao Department of Radiology, The First Affiliated Hospital of Zhengzhou University, No. 1 Construction East Road, 450000, Zhengzhou, China aut NATIONALLICENCE 700 1- Dong Dong Department of Rhinology, The First Affiliated Hospital of Zhengzhou University, 450000, Zhengzhou, China aut NATIONALLICENCE 700 1- Cheng Jingliang Department of Radiology, The First Affiliated Hospital of Zhengzhou University, No. 1 Construction East Road, 450000, Zhengzhou, China aut NATIONALLICENCE 700 1- Fan Xinjuan Department of Pathology, The Sixth Affiliated Hospital of Sun Yat-sen University, 450000, Guangzhou, China aut NATIONALLICENCE 700 1- Zhao Yulin Department of Rhinology, The First Affiliated Hospital of Zhengzhou University, 450000, Zhengzhou, China aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/9(2015-09-01), 2363-2369 0937-4477 272:9<2363 2015 272 405