caa a22 4500 606183809 CHVBK 20210128100823.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s00405-014-3042-2 doi (NATIONALLICENCE)springer-10.1007/s00405-014-3042-2 Horizontal VOR function shows frequency dynamics in vestibular schwannoma [Elektronische Daten] [Alexander Blödow, Julia Blödow, Marc Bloching, Ralf Helbig, Leif Walther] The objective of this retrospective study was to investigate the horizontal vestibulo-ocular reflex (hVOR) pathway with caloric test (low-frequency hVOR) and video head impulse test (vHIT) (high-frequency hVOR) in patients with sporadic vestibular schwannoma (69 patients, 27-86years, mean age 58.1years) and to compare both test methods in terms of their sensitivity and specificity to detect a retrocochlear lesion. Test results with a unilateral weakness (UWCaloric)>25% (caloric test) or a Mean-GainvHIT<0.79/asymmetry ratio of Gain (AR-GainvHIT)>8.5% and accompanied refixation saccades (vHIT) were considered abnormal. The overall sensitivity of the caloric test was 72%. The evaluation of AR-GainvHIT detected more abnormal cases than did Mean-GainvHIT (44 vs. 36%). In up to 4%, a normal caloric test result was related to an abnormal vHIT. There was only a moderate correlation of UWCaloric and AR-GainvHIT (r=0.54, p<0.05) with a linear regression line intercept/slope of 32.2/0.9 (p<0.05). Receiver operating characteristics curve analysis exhibited at a UWCaloric of 50% a vHIT sensitivity/specificity/positive predictive value/negative predictive value of 0.45/0.9/0.94/0.42. Vestibular testing at varying frequencies provides deeper insights into hVOR function and is helpful in detecting a cerebello-pontine lesion. Whereas caloric test yields a high sensitivity for nerve dysfunction, vHIT test reveals a remaining function of hVOR in the high-frequency range. Springer-Verlag Berlin Heidelberg, 2014 Vestibular schwannoma nationallicence Video head impulse test nationallicence Caloric test nationallicence Vertigo nationallicence Dizziness nationallicence Blödow Alexander Department of Otorhinolaryngology, Head and Neck Surgery and Communication Disorders, HELIOS-Clinic Berlin-Buch, Schwanebecker Chaussee 50, 13125, Berlin, Germany aut Blödow Julia Department of Otorhinolaryngology, Head and Neck Surgery and Communication Disorders, HELIOS-Clinic Berlin-Buch, Schwanebecker Chaussee 50, 13125, Berlin, Germany aut Bloching Marc Department of Otorhinolaryngology, Head and Neck Surgery and Communication Disorders, HELIOS-Clinic Berlin-Buch, Schwanebecker Chaussee 50, 13125, Berlin, Germany aut Helbig Ralf Department of Otorhinolaryngology, Head and Neck Surgery and Communication Disorders, HELIOS-Clinic Berlin-Buch, Schwanebecker Chaussee 50, 13125, Berlin, Germany aut Walther Leif Department of Otorhinolaryngology, Head and Neck Surgery, University Medicine Mannheim, Mannheim, Germany aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/9(2015-09-01), 2143-2148 0937-4477 272:9<2143 2015 272 405 https://doi.org/10.1007/s00405-014-3042-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-3042-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Blödow Alexander Department of Otorhinolaryngology, Head and Neck Surgery and Communication Disorders, HELIOS-Clinic Berlin-Buch, Schwanebecker Chaussee 50, 13125, Berlin, Germany aut NATIONALLICENCE 700 1- Blödow Julia Department of Otorhinolaryngology, Head and Neck Surgery and Communication Disorders, HELIOS-Clinic Berlin-Buch, Schwanebecker Chaussee 50, 13125, Berlin, Germany aut NATIONALLICENCE 700 1- Bloching Marc Department of Otorhinolaryngology, Head and Neck Surgery and Communication Disorders, HELIOS-Clinic Berlin-Buch, Schwanebecker Chaussee 50, 13125, Berlin, Germany aut NATIONALLICENCE 700 1- Helbig Ralf Department of Otorhinolaryngology, Head and Neck Surgery and Communication Disorders, HELIOS-Clinic Berlin-Buch, Schwanebecker Chaussee 50, 13125, Berlin, Germany aut NATIONALLICENCE 700 1- Walther Leif Department of Otorhinolaryngology, Head and Neck Surgery, University Medicine Mannheim, Mannheim, Germany aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/9(2015-09-01), 2143-2148 0937-4477 272:9<2143 2015 272 405