caa a22 4500 606183914 CHVBK 20210128100823.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s00405-014-3081-8 doi (NATIONALLICENCE)springer-10.1007/s00405-014-3081-8 Pyriform sinus squamous cell carcinoma: oncological outcomes in good responders of induction chemotherapy-based larynx preservation protocols [Elektronische Daten] [Zacharias Vourexakis, Anne-Marie Le Ridant, Pavel Dulguerov, François Janot] Induction chemotherapy-based larynx preservation protocols use chemotherapy to select exclusively patients with ‘chemosensitive' tumors for a nonsurgical treatment with radiation therapy. This study on pyriform sinus squamous cell carcinoma (SCC) is interested in the oncological outcome of treatment based on radiation therapy when offered to patients with tumors responding to induction chemotherapy. This was a retrospective cohort study. The cohort included good responders to induction chemotherapy, subsequently treated with definite radiation therapy (with or without concomitant chemotherapy) for pyriform sinus SCC, in a tertiary referral cancer center. The primary endpoints were overall, laryngectomy-free and disease-free survival and the secondary endpoints were analysis of treatment failures and possibilities of salvage treatment. Forty-two patients fulfilled the inclusion criteria and were retained for analysis; 7% were stage II (3/42), 48% stage III (20/42) and 45% stage IV (19/42). At 1, 3 and 5years, the overall survival was 95% (40/42), 74% (31/42), and 60% (SE≈0.08), respectively. For the same intervals, the laryngectomy-free survival was 90% (38/42), 69% (29/42) and 50% (SE≈0.08), respectively. The estimated 5-year disease-free survival was also 50%. Disease-free survival was significantly better for N0 patients. There was a 28% recurrence rate, mainly in the primary tumor site (9/11), with or without simultaneous nodal recurrence. Interestingly, more than one-third of all oncologic failures occurred beyond the first 3years of follow-up. Salvage treatment was not possible or definitely inefficient in at least 2/3 of all recurrences. In candidates for larynx preservation for a pyriform sinus SCC, good response to induction chemotherapy followed by definite radiation therapy seems to be associated with a more favorable prognosis. Nevertheless, in case of locoregional recurrence the possibilities for efficient salvage treatment are limited. Springer-Verlag Berlin Heidelberg, 2014 Pyriform sinus nationallicence Chemosensitive nationallicence Responders nationallicence Radiation therapy nationallicence Survival nationallicence SCC : Squamous cell carcinoma nationallicence ICT : Induction (neoadjuvant) chemotherapy nationallicence RT : Radiation therapy nationallicence CRT : Radiation therapy with concomitant chemotherapy nationallicence IGR : Institut Gustave Roussy nationallicence PF : Platinum salt and 5-fluorouracil nationallicence TPF : Taxane and PF nationallicence OS : Overall survival nationallicence DFS : Disease-free survival nationallicence LFS : Laryngectomy-free survival nationallicence Vourexakis Zacharias Department of Head and Neck Surgery, Institut Gustave Roussy, Villejuif, France aut Le Ridant Anne-Marie Department of Head and Neck Surgery, Institut Gustave Roussy, Villejuif, France aut Dulguerov Pavel Department of Otolaryngology-Head and Neck Surgery, University Hospital of Geneva and University of Geneva School of Medicine, Geneva, Switzerland aut Janot François Department of Head and Neck Surgery, Institut Gustave Roussy, Villejuif, France aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/7(2015-07-01), 1725-1731 0937-4477 272:7<1725 2015 272 405 https://doi.org/10.1007/s00405-014-3081-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-3081-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Vourexakis Zacharias Department of Head and Neck Surgery, Institut Gustave Roussy, Villejuif, France aut NATIONALLICENCE 700 1- Le Ridant Anne-Marie Department of Head and Neck Surgery, Institut Gustave Roussy, Villejuif, France aut NATIONALLICENCE 700 1- Dulguerov Pavel Department of Otolaryngology-Head and Neck Surgery, University Hospital of Geneva and University of Geneva School of Medicine, Geneva, Switzerland aut NATIONALLICENCE 700 1- Janot François Department of Head and Neck Surgery, Institut Gustave Roussy, Villejuif, France aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/7(2015-07-01), 1725-1731 0937-4477 272:7<1725 2015 272 405