caa a22 4500 60618399X CHVBK 20210128100824.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s00405-014-3105-4 doi (NATIONALLICENCE)springer-10.1007/s00405-014-3105-4 Expression of podoplanin and prognosis in oropharyngeal cancer [Elektronische Daten] [Simon Preuss, Andreas Anagiotos, Inga Seuthe, Uta Drebber, Inga Wedemeyer, Matthias Kreppel, Robert Semrau, Guy Eslick, Jens Klussmann, Christian Huebbers] It has been shown that podoplanin expression is associated with carcinoma of the aerodigestive tract. Recent studies indicate that podoplanin may serve as a prognostic biomarker in oral carcinoma. In order to provide evidence on the role of podoplanin in oropharyngeal squamous cell carcinoma, we evaluated the prognostic impact of podoplanin in these patients. We analyzed formalin-fixed tissue samples from 107 consecutive patients with oropharyngeal squamous cell carcinoma. HPV typing and immunohistochemical staining for both p16 and podoplanin were performed. Expression of podoplanin was seen in 38.3% of all cases. We found no correlation of the podoplanin scores with either p16 expression or with HPV status. There was no significant correlation of podoplanin expression with the staging variables T, N, M, and tumor grading. Podoplanin expression did neither influence the 5-year overall survival nor the 5-year disease-free survival. Concluding, we could not find a prognostic role of podoplanin expression neither in the HPV-positive cases nor in the HPV-negative cases. It appears that podoplanin is not expressed as often in oropharyngeal cancer compared to oral cancer. We could not show any relation of lymph node metastases and podoplanin expression in this homogenous cohort of tumors. Springer-Verlag Berlin Heidelberg, 2014 Oncology nationallicence Podoplanin nationallicence Oropharyngeal cancer nationallicence Human papillomavirus nationallicence Survival nationallicence Preuss Simon Department of Otorhinolaryngology, Head and Neck Surgery, University of Cologne, Medical Faculty, Cologne, Germany aut Anagiotos Andreas Department of Otorhinolaryngology, Head and Neck Surgery, University of Cologne, Medical Faculty, Cologne, Germany aut Seuthe Inga Department of Otorhinolaryngology, Head and Neck Surgery, University of Cologne, Medical Faculty, Cologne, Germany aut Drebber Uta Institute of Pathology, University Hospital of Cologne, Cologne, Germany aut Wedemeyer Inga Institute of Pathology, University Hospital of Cologne, Cologne, Germany aut Kreppel Matthias Department for Oral and Cranio-Maxillo and Facial Plastic Surgery, University of Cologne, Cologne, Germany aut Semrau Robert Department of Radiation Oncology, University Hospital of Cologne, Cologne, Germany aut Eslick Guy The Whiteley-Martin Research Centre, Discipline of Surgery, The University of Sydney, Sydney, NSW, Australia aut Klussmann Jens Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Giessen, Giessen, Germany aut Huebbers Christian Jean-Uhrmacher-Institute for Otorhinolaryngological Research, University of Cologne, Cologne, Germany aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/7(2015-07-01), 1749-1754 0937-4477 272:7<1749 2015 272 405 https://doi.org/10.1007/s00405-014-3105-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-3105-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Preuss Simon Department of Otorhinolaryngology, Head and Neck Surgery, University of Cologne, Medical Faculty, Cologne, Germany aut NATIONALLICENCE 700 1- Anagiotos Andreas Department of Otorhinolaryngology, Head and Neck Surgery, University of Cologne, Medical Faculty, Cologne, Germany aut NATIONALLICENCE 700 1- Seuthe Inga Department of Otorhinolaryngology, Head and Neck Surgery, University of Cologne, Medical Faculty, Cologne, Germany aut NATIONALLICENCE 700 1- Drebber Uta Institute of Pathology, University Hospital of Cologne, Cologne, Germany aut NATIONALLICENCE 700 1- Wedemeyer Inga Institute of Pathology, University Hospital of Cologne, Cologne, Germany aut NATIONALLICENCE 700 1- Kreppel Matthias Department for Oral and Cranio-Maxillo and Facial Plastic Surgery, University of Cologne, Cologne, Germany aut NATIONALLICENCE 700 1- Semrau Robert Department of Radiation Oncology, University Hospital of Cologne, Cologne, Germany aut NATIONALLICENCE 700 1- Eslick Guy The Whiteley-Martin Research Centre, Discipline of Surgery, The University of Sydney, Sydney, NSW, Australia aut NATIONALLICENCE 700 1- Klussmann Jens Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Giessen, Giessen, Germany aut NATIONALLICENCE 700 1- Huebbers Christian Jean-Uhrmacher-Institute for Otorhinolaryngological Research, University of Cologne, Cologne, Germany aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/7(2015-07-01), 1749-1754 0937-4477 272:7<1749 2015 272 405