caa a22 4500 606184023 CHVBK 20210128100824.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s00405-014-3104-5 doi (NATIONALLICENCE)springer-10.1007/s00405-014-3104-5 Impact of prophylactic central neck dissection on oncologic outcomes of papillary thyroid carcinoma: a review [Elektronische Daten] [Elisabeth Mamelle, Isabelle Borget, Sophie Leboulleux, Haïtham Mirghani, Carlos Suárez, Phillip Pellitteri, Ashok Shaha, Marc Hamoir, K. Robbins, Avi Khafif, Juan Rodrigo, Carl Silver, Alessandra Rinaldo, Alfio Ferlito, Dana Hartl] Prophylactic neck dissection (PND) for papillary thyroid carcinoma (PTC) is controversial. Our aim was to assess current levels of evidence (LE) according to the Oxford Centre for Evidence-based Medicine ( http://www.cebm.net/?O=1025 ) regarding the oncologic benefits of PND. Data were analyzed via MEDLINE keywords: PTC, differentiated thyroid carcinoma, PND, central lymph node metastases, central compartment, recurrence-free survival. There was conflicting evidence regarding the rate of reoperation for recurrence, with some studies showing a lower rate after PND with increased recurrence-free survival and a higher rate of undetectable pre- and post-ablation thyroglobulin levels (LE 4), whereas other studies did not show a difference (LE 4). Only one study (LE 4) showed improved disease-specific survival with PND. PND may improve recurrence-free survival, although this is supported by only a low LE. Current recommendations can only be based on low-level evidence. Springer-Verlag Berlin Heidelberg, 2014 Lymph node metastasis nationallicence Prophylactic neck dissection nationallicence Papillary thyroid carcinoma nationallicence Recurrence-free survival nationallicence Radioactive iodine nationallicence Mamelle Elisabeth Thyroid Surgery Unit, Department of Head and Neck Oncology, Institut Gustave Roussy, Paris-Sud University, Villejuif, France aut Borget Isabelle Biostatistics and Epidemiology Unit, Department of Clinical Research, Institut Gustave Roussy, Paris-Sud University, Villejuif, France aut Leboulleux Sophie Department of Nuclear Medicine and Endocrine Oncology, Institut Gustave Roussy, Paris-Sud University, Villejuif, France aut Mirghani Haïtham Thyroid Surgery Unit, Department of Head and Neck Oncology, Institut Gustave Roussy, Paris-Sud University, Villejuif, France aut Suárez Carlos Department of Otolaryngology, Hospital Universitario Central de Asturias, Oviedo, Spain aut Pellitteri Phillip Department of Otolaryngology-Head and Neck Surgery, Guthrie Health System, Sayre, PA, USA aut Shaha Ashok Department of Head and Neck Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USA aut Hamoir Marc Department of Head and Neck Surgery, Head and Neck Oncology Program, St Luc University Hospital and Cancer Center, Brussels, Belgium aut Robbins K. Division of Otolaryngology-Head and Neck Surgery, Southern Illinois University School of Medicine, Springfield, IL, USA aut Khafif Avi Head and Neck Surgery and Oncology Unit, A.R.M. Center for Advanced Otolaryngology Head and Neck Surgery, Assuta Medical Center, Tel Aviv, Israel aut Rodrigo Juan Department of Otolaryngology, Hospital Universitario Central de Asturias, Oviedo, Spain aut Silver Carl Departments of Surgery and Otolaryngology-Head and Neck Surgery, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA aut Rinaldo Alessandra University of Udine School of Medicine, Piazzale S. Maria della Misericordia, 33100, Udine, Italy aut Ferlito Alfio University of Udine School of Medicine, Piazzale S. Maria della Misericordia, 33100, Udine, Italy aut Hartl Dana Thyroid Surgery Unit, Department of Head and Neck Oncology, Institut Gustave Roussy, Paris-Sud University, Villejuif, France aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/7(2015-07-01), 1577-1586 0937-4477 272:7<1577 2015 272 405 https://doi.org/10.1007/s00405-014-3104-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-3104-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mamelle Elisabeth Thyroid Surgery Unit, Department of Head and Neck Oncology, Institut Gustave Roussy, Paris-Sud University, Villejuif, France aut NATIONALLICENCE 700 1- Borget Isabelle Biostatistics and Epidemiology Unit, Department of Clinical Research, Institut Gustave Roussy, Paris-Sud University, Villejuif, France aut NATIONALLICENCE 700 1- Leboulleux Sophie Department of Nuclear Medicine and Endocrine Oncology, Institut Gustave Roussy, Paris-Sud University, Villejuif, France aut NATIONALLICENCE 700 1- Mirghani Haïtham Thyroid Surgery Unit, Department of Head and Neck Oncology, Institut Gustave Roussy, Paris-Sud University, Villejuif, France aut NATIONALLICENCE 700 1- Suárez Carlos Department of Otolaryngology, Hospital Universitario Central de Asturias, Oviedo, Spain aut NATIONALLICENCE 700 1- Pellitteri Phillip Department of Otolaryngology-Head and Neck Surgery, Guthrie Health System, Sayre, PA, USA aut NATIONALLICENCE 700 1- Shaha Ashok Department of Head and Neck Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USA aut NATIONALLICENCE 700 1- Hamoir Marc Department of Head and Neck Surgery, Head and Neck Oncology Program, St Luc University Hospital and Cancer Center, Brussels, Belgium aut NATIONALLICENCE 700 1- Robbins K. Division of Otolaryngology-Head and Neck Surgery, Southern Illinois University School of Medicine, Springfield, IL, USA aut NATIONALLICENCE 700 1- Khafif Avi Head and Neck Surgery and Oncology Unit, A.R.M. Center for Advanced Otolaryngology Head and Neck Surgery, Assuta Medical Center, Tel Aviv, Israel aut NATIONALLICENCE 700 1- Rodrigo Juan Department of Otolaryngology, Hospital Universitario Central de Asturias, Oviedo, Spain aut NATIONALLICENCE 700 1- Silver Carl Departments of Surgery and Otolaryngology-Head and Neck Surgery, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA aut NATIONALLICENCE 700 1- Rinaldo Alessandra University of Udine School of Medicine, Piazzale S. Maria della Misericordia, 33100, Udine, Italy aut NATIONALLICENCE 700 1- Ferlito Alfio University of Udine School of Medicine, Piazzale S. Maria della Misericordia, 33100, Udine, Italy aut NATIONALLICENCE 700 1- Hartl Dana Thyroid Surgery Unit, Department of Head and Neck Oncology, Institut Gustave Roussy, Paris-Sud University, Villejuif, France aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/7(2015-07-01), 1577-1586 0937-4477 272:7<1577 2015 272 405