caa a22 4500 60618404X CHVBK 20210128100824.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s00405-014-3243-8 doi (NATIONALLICENCE)springer-10.1007/s00405-014-3243-8 Increased frequency of mitral valve prolapse in patients with deviated nasal septum [Elektronische Daten] [Hasan Arslan, Mustafa Aparci, Zekeriya Arslan, Cengiz Ozturk, Zafer Isilak, Sevket Balta, Turgay Celik, Atila Iyisoy] Any abnormality of collagen may affect the tissues with higher collagen content, e.g., joints, heart valves, and great arteries. Mitral valve prolapse (MVP) is a characteristic of generalized collagen abnormality. Nasal septum (NS) is constituted by osseous and cartilaginous septums that are highly rich in collagen. We evaluated the co-existence of deviation of NS (DNS) in patients with MVP. We retrospectively evaluated the recordings of echocardiographic and nasal examinations of subjects with MVP and DNS. We analyzed the features of MVP and anatomical classification of DNS among subjects. Totally, 74 patients with DNS and 38 subjects with normal nasal passage were enrolled to the study. Presence of MVP was significantly higher in patients with DNS compared to normal subjects (63 vs 26%, p<0.001). Prolapse of anterior, posterior and both leaflets was higher in patients with DNS. Thickness of anterior mitral leaflet was significantly increased in patients with DNS (3.57±0.68 vs 4.59±1.1mm, p<0.001) compared to normal subjects. Type I, II, and III, IV DNS were higher in frequency in patients with MVP while type V and VI were higher in normal subjects. DNS is highly co-existent with MVP and increased thickness of mitral anterior leaflet. Generalized abnormality of collagen which is the main component of mitral valves and nasal septum may be accounted for co-existence of MVP and DNS. Also co-existence of them may exaggerate the symptoms of patients with MVP due to limited airflow through the nasal passage. Springer-Verlag Berlin Heidelberg, 2014 Mitral valve prolapse nationallicence Deviated nasal septum nationallicence Collagen nationallicence Cartilage nationallicence NS : Nasal septum nationallicence DNS : Deviated nasal septum nationallicence MV : Mitral valve nationallicence MVP : Mitral valve prolapse nationallicence Arslan Hasan Department of Otolaryngology, Etimesgut Military Hospital, Ankara, Turkey aut Aparci Mustafa Department of Cardiology, Etimesgut Military Hospital, Ankara, Turkey aut Arslan Zekeriya Department of Cardiology, Mevki Military Hospital, Ankara, Turkey aut Ozturk Cengiz Department of Cardiology, Gulhane Military Medical Academy, Ankara, Turkey aut Isilak Zafer Department of Cardiology, Haydarpasa Training Hospital, Istanbul, Turkey aut Balta Sevket Department of Cardiology, Eskişehir Military Hospital, Vişnelik Mah., Atatürk Cd., 26020, Akarbaşı/Eskişehir, Turkey aut Celik Turgay Department of Cardiology, Gulhane Military Medical Academy, Ankara, Turkey aut Iyisoy Atila Department of Cardiology, Gulhane Military Medical Academy, Ankara, Turkey aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/7(2015-07-01), 1667-1671 0937-4477 272:7<1667 2015 272 405 https://doi.org/10.1007/s00405-014-3243-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-3243-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Arslan Hasan Department of Otolaryngology, Etimesgut Military Hospital, Ankara, Turkey aut NATIONALLICENCE 700 1- Aparci Mustafa Department of Cardiology, Etimesgut Military Hospital, Ankara, Turkey aut NATIONALLICENCE 700 1- Arslan Zekeriya Department of Cardiology, Mevki Military Hospital, Ankara, Turkey aut NATIONALLICENCE 700 1- Ozturk Cengiz Department of Cardiology, Gulhane Military Medical Academy, Ankara, Turkey aut NATIONALLICENCE 700 1- Isilak Zafer Department of Cardiology, Haydarpasa Training Hospital, Istanbul, Turkey aut NATIONALLICENCE 700 1- Balta Sevket Department of Cardiology, Eskişehir Military Hospital, Vişnelik Mah., Atatürk Cd., 26020, Akarbaşı/Eskişehir, Turkey aut NATIONALLICENCE 700 1- Celik Turgay Department of Cardiology, Gulhane Military Medical Academy, Ankara, Turkey aut NATIONALLICENCE 700 1- Iyisoy Atila Department of Cardiology, Gulhane Military Medical Academy, Ankara, Turkey aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/7(2015-07-01), 1667-1671 0937-4477 272:7<1667 2015 272 405