caa a22 4500 606184066 CHVBK 20210128100824.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s00405-014-3117-0 doi (NATIONALLICENCE)springer-10.1007/s00405-014-3117-0 The clinical relevance of Ki-67 expression in laryngeal squamous cell carcinoma [Elektronische Daten] [Federico Gioacchini, Matteo Alicandri-Ciufelli, Giuseppe Magliulo, Corrado Rubini, Livio Presutti, Massimo Re] The aim of this study was to determine the prognostic value of Ki-67 immunostaining in patients affected by laryngeal squamous cell carcinoma. A systematic review was carried out in a tertiary university referral center. An appropriate string was run on PubMed to retrieve articles dealing with Ki-67 immunohistochemical staining and laryngeal squamous cell carcinoma. A double cross-check was performed on citations and full-text articles by two investigators independently to review all manuscripts and perform a comprehensive quality assessment. Of 85 abstracts identified, 18 articles were included. These studies reported on 1,342 patients with histological confirmed diagnosis of laryngeal squamous cell carcinoma. Most studies showed a statistical association between Ki-67 immunohistochemical expression and at least one of the clinical and histopathological parameters considered by the authors. Overall the studies analyzed suggested that the tumoral proliferative index was statistically connected respectively with T stage (2/18), N stage (4/18), grading (6/18), disease-free survival (10/18) and overall survival (4/18). Our review strongly suggests that immunohistochemical staining of Ki-67 correlates with tumoral aggressiveness and worse prognosis in patients affected by laryngeal squamous cell carcinoma. Further high-quality prospective studies should be carried out to confirm our finding and determine the eventual differences between cancers of specific laryngeal subsites. Springer-Verlag Berlin Heidelberg, 2014 Laryngeal squamous carcinoma nationallicence Immunohistochemistry nationallicence Ki-67 nationallicence Prognostic factors nationallicence Gioacchini Federico Otolaryngology Department, University Hospital of Modena, Via del Pozzo 71, 41100, Modena, Italy aut Alicandri-Ciufelli Matteo Otolaryngology Department, University Hospital of Modena, Via del Pozzo 71, 41100, Modena, Italy aut Magliulo Giuseppe Department of Otorhinolaryngology ‘‘G. Ferreri'', ‘‘La Sapienza'' University, 00185, Rome, Italy aut Rubini Corrado Pathologic Anatomy and Histopathology Division, Department of Biomedical Sciences and Public Health, Polytechnic University of the Marches, 60100, Ancona, Italy aut Presutti Livio Otolaryngology Department, University Hospital of Modena, Via del Pozzo 71, 41100, Modena, Italy aut Re Massimo Otorhinolaryngology Department, Marche Polytechnic University, 60100, Ancona, Italy aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/7(2015-07-01), 1569-1576 0937-4477 272:7<1569 2015 272 405 https://doi.org/10.1007/s00405-014-3117-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-3117-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gioacchini Federico Otolaryngology Department, University Hospital of Modena, Via del Pozzo 71, 41100, Modena, Italy aut NATIONALLICENCE 700 1- Alicandri-Ciufelli Matteo Otolaryngology Department, University Hospital of Modena, Via del Pozzo 71, 41100, Modena, Italy aut NATIONALLICENCE 700 1- Magliulo Giuseppe Department of Otorhinolaryngology ‘‘G. Ferreri'', ‘‘La Sapienza'' University, 00185, Rome, Italy aut NATIONALLICENCE 700 1- Rubini Corrado Pathologic Anatomy and Histopathology Division, Department of Biomedical Sciences and Public Health, Polytechnic University of the Marches, 60100, Ancona, Italy aut NATIONALLICENCE 700 1- Presutti Livio Otolaryngology Department, University Hospital of Modena, Via del Pozzo 71, 41100, Modena, Italy aut NATIONALLICENCE 700 1- Re Massimo Otorhinolaryngology Department, Marche Polytechnic University, 60100, Ancona, Italy aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/7(2015-07-01), 1569-1576 0937-4477 272:7<1569 2015 272 405