caa a22 4500 606184090 CHVBK 20210128100824.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s00405-014-3116-1 doi (NATIONALLICENCE)springer-10.1007/s00405-014-3116-1 Prognostic significance of lymph node ratio in patients with Merkel cell carcinoma [Elektronische Daten] [Alexandra Fochtmann, Georg Haymerle, Rainer Kunstfeld, Johannes Pammer, Matthaeus Grasl, Boban Erovic] Merkel cell carcinoma is a rare and aggressive metastasizing tumor of the skin. Lymph node metastasis is a significant clinical prognostic factor for overall and disease-free survival in patients with Merkel cell carcinoma. A retrospective medical chart review of 12 Merkel cell carcinoma patients was performed. All patients received treatment at the Medical University of Vienna and underwent lymph node dissection between 1994 and 2013. The lymph node ratio was determined by dividing the total number of positive lymph nodes by the entire number of dissected lymph nodes. A positive lymph node ratio was defined as a number >0 and the negative lymph node ratio was defined by zero. The median follow-up was 44months (range 4-92). A positive lymph node ratio (range 1.00-0.04) was found in 7 (58%) out of 12 patients of whom 5 (71%) died of disease. A negative lymph node ratio was found in 5 (42%) out of 12 patients of whom 2 (40%) patients died of disease. The disease-specific death rate was higher in patients diagnosed with a positive lymph node ratio compared to patients diagnosed with a negative lymph node ratio. Based on these preliminary findings, there might be a prognostic impact of lymph node ratio in patients suffering from Merkel cell carcinoma. Springer-Verlag Berlin Heidelberg, 2014 Merkel cell carcinoma nationallicence Lymph node dissection nationallicence Sentinel lymph node biopsy nationallicence Lymph node ratio nationallicence Neck dissection nationallicence Fochtmann Alexandra Department Otolaryngology, Head and Neck Surgery, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria aut Haymerle Georg Department Otolaryngology, Head and Neck Surgery, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria aut Kunstfeld Rainer Department of Dermatology, Medical University of Vienna, Vienna, Austria aut Pammer Johannes Clinical Department of Pathology, Medical University of Vienna, Vienna, Austria aut Grasl Matthaeus Department Otolaryngology, Head and Neck Surgery, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria aut Erovic Boban Department Otolaryngology, Head and Neck Surgery, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/7(2015-07-01), 1777-1783 0937-4477 272:7<1777 2015 272 405 https://doi.org/10.1007/s00405-014-3116-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-3116-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fochtmann Alexandra Department Otolaryngology, Head and Neck Surgery, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria aut NATIONALLICENCE 700 1- Haymerle Georg Department Otolaryngology, Head and Neck Surgery, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria aut NATIONALLICENCE 700 1- Kunstfeld Rainer Department of Dermatology, Medical University of Vienna, Vienna, Austria aut NATIONALLICENCE 700 1- Pammer Johannes Clinical Department of Pathology, Medical University of Vienna, Vienna, Austria aut NATIONALLICENCE 700 1- Grasl Matthaeus Department Otolaryngology, Head and Neck Surgery, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria aut NATIONALLICENCE 700 1- Erovic Boban Department Otolaryngology, Head and Neck Surgery, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/7(2015-07-01), 1777-1783 0937-4477 272:7<1777 2015 272 405