caa a22 4500 606184155 CHVBK 20210128100824.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s00405-014-3115-2 doi (NATIONALLICENCE)springer-10.1007/s00405-014-3115-2 Preservation of laryngeal function improves outcomes of patients with hypopharyngeal carcinoma [Elektronische Daten] [Tong Jin, Xuezhong Li, Dapeng Lei, Dayu Liu, Qiuan Yang, Guojun Li, Xinliang Pan] This study compares clinical characteristics and survival between patients with and without laryngeal function (LF) preservation during surgical treatment for hypopharyngeal carcinoma. We retrospectively reviewed 485 cases of hypopharyngeal carcinoma treated at a single institution for analysis. There were 337 cases with and 148 cases without LF preservation after surgery. Preservation of LF was complete in 237 patients and partial in 100 patients. There were significant statistical differences between the preservation group and the group without preservation in T-stage (P<0.001), overall staging (P<0.001), and tumor sites (P<0.001) except the N-stage (P=0.240). The patients with LF preservation had significantly better overall survival (log-rank, P=0.005) and a lower risk of death than those without LF preservation (HR 0.62, 95% CI 0.43-0.97), after multivariable adjustment. Treatment with surgery in combination with radiotherapy is still the favorable choice for patients with hypopharyngeal carcinoma. The maximal restoration of pharyngoesophageal continuity and function improves survival for patients whose tumors are excised completely for the preservation of LF and laryngeal and pharyngeal reconstruction. The Author(s), 2014 Function preservation nationallicence Hypopharyngeal squamous cell carcinoma nationallicence Laryngectomy nationallicence Pharyngectomy nationallicence Survival nationallicence Life quality nationallicence LF : Laryngeal function nationallicence TNF-α : Tumor necrosis factor-alpha nationallicence SCCHN : Squamous cell carcinoma of the head and neck nationallicence HR : Hazard ratio nationallicence CI : Confidence interval nationallicence PCR : Polymerase chain reaction nationallicence SNPs : Single nucleotide polymorphisms nationallicence SCCNOP : Squamous cell carcinomas of the nonoropharynx nationallicence Jin Tong Department of Otorhinolaryngology, Qilu Hospital, Shandong University, Key Laboratory of Otolaryngology, Ministry of Health, 107 West Wenhua Road, 250012, Jinan, Shandong, People's Republic of China aut Li Xuezhong Department of Otorhinolaryngology, Qilu Hospital, Shandong University, Key Laboratory of Otolaryngology, Ministry of Health, 107 West Wenhua Road, 250012, Jinan, Shandong, People's Republic of China aut Lei Dapeng Department of Otorhinolaryngology, Qilu Hospital, Shandong University, Key Laboratory of Otolaryngology, Ministry of Health, 107 West Wenhua Road, 250012, Jinan, Shandong, People's Republic of China aut Liu Dayu Department of Otorhinolaryngology, Qilu Hospital, Shandong University, Key Laboratory of Otolaryngology, Ministry of Health, 107 West Wenhua Road, 250012, Jinan, Shandong, People's Republic of China aut Yang Qiuan Department of Radiation, Oncology Center, Qilu Hospital of Shandong University, 250012, Jinan, Shandong, People's Republic of China aut Li Guojun Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1445, 77030-4009, Houston, TX, USA aut Pan Xinliang Department of Otorhinolaryngology, Qilu Hospital, Shandong University, Key Laboratory of Otolaryngology, Ministry of Health, 107 West Wenhua Road, 250012, Jinan, Shandong, People's Republic of China aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/7(2015-07-01), 1785-1791 0937-4477 272:7<1785 2015 272 405 https://doi.org/10.1007/s00405-014-3115-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-3115-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Jin Tong Department of Otorhinolaryngology, Qilu Hospital, Shandong University, Key Laboratory of Otolaryngology, Ministry of Health, 107 West Wenhua Road, 250012, Jinan, Shandong, People's Republic of China aut NATIONALLICENCE 700 1- Li Xuezhong Department of Otorhinolaryngology, Qilu Hospital, Shandong University, Key Laboratory of Otolaryngology, Ministry of Health, 107 West Wenhua Road, 250012, Jinan, Shandong, People's Republic of China aut NATIONALLICENCE 700 1- Lei Dapeng Department of Otorhinolaryngology, Qilu Hospital, Shandong University, Key Laboratory of Otolaryngology, Ministry of Health, 107 West Wenhua Road, 250012, Jinan, Shandong, People's Republic of China aut NATIONALLICENCE 700 1- Liu Dayu Department of Otorhinolaryngology, Qilu Hospital, Shandong University, Key Laboratory of Otolaryngology, Ministry of Health, 107 West Wenhua Road, 250012, Jinan, Shandong, People's Republic of China aut NATIONALLICENCE 700 1- Yang Qiuan Department of Radiation, Oncology Center, Qilu Hospital of Shandong University, 250012, Jinan, Shandong, People's Republic of China aut NATIONALLICENCE 700 1- Li Guojun Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1445, 77030-4009, Houston, TX, USA aut NATIONALLICENCE 700 1- Pan Xinliang Department of Otorhinolaryngology, Qilu Hospital, Shandong University, Key Laboratory of Otolaryngology, Ministry of Health, 107 West Wenhua Road, 250012, Jinan, Shandong, People's Republic of China aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/7(2015-07-01), 1785-1791 0937-4477 272:7<1785 2015 272 405