caa a22 4500 606184252 CHVBK 20210128100825.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s00405-015-3696-4 doi (NATIONALLICENCE)springer-10.1007/s00405-015-3696-4 Dysphagia and health-related quality of life in patients with eosinophilic esophagitis: a long-term follow-up [Elektronische Daten] [Helen Larsson, Karin Bergman, Caterina Finizia, Leif Johansson, Mogens Bove, Henrik Bergquist] Eosinophilic esophagitis (EoE) is a chronic immune/antigen-mediated disease, with dysphagia as the main symptom. The aim of this study was to survey symptoms and health-related quality of life in adult patients with EoE at least 1year after diagnosis and a 2-month course of topical corticosteroids. Forty-seven consecutive patients [79% males, mean age 49years (range 18-90years)] were evaluated using three different questionnaires at three different occasions: the Watson Dysphagia Scale (WDS), the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Oesophageal Module 18 (EORTC QLQ-OES18) and the Short Form-36 (SF-36). The median time from diagnosis to the long-term follow-up was 23months (range 12-34months). The WDS scores and the EORTC QLQ-OES18 Dysphagia and Eating scale scores were improved after 2months of treatment (p=0.00007, p=0.01, p=0.004, respectively), as were the long-term follow-up scores (p=0.01, p=0.03, p=0.005, respectively), relative to the scores at diagnosis. In addition, the EORTC QLQ-OES18 Choking scores were improved after the steroid course (p=0.003) but not after the long-term follow-up. No significant differences were detected with respect to the SF-36 scores. In summary, EoE seems to be associated with a substantial burden of symptoms that improve significantly after treatment. A partial remission persists more than 1year after diagnosis and the discontinuation of medication. The WDS and the EORTC QLQ-OES18 appear to be sensitive instruments appropriate for surveillance in these patients. Springer-Verlag Berlin Heidelberg, 2015 Eosinophilic esophagitis nationallicence Dysphagia nationallicence Quality of life nationallicence Follow-up nationallicence Questionnaires nationallicence Larsson Helen Department of Otorhinolaryngology, NAL Medical Centre, 46185, Trollhättan, Sweden aut Bergman Karin Department of Otorhinolaryngology, NAL Medical Centre, 46185, Trollhättan, Sweden aut Finizia Caterina Department of ENT/H&N Surgery, Sahlgrenska University Hospital, University of Gothenburg, Gothenburg, Sweden aut Johansson Leif Department of Otorhinolaryngology, Skövde County Hospital, Skövde, Sweden aut Bove Mogens Department of Otorhinolaryngology, NAL Medical Centre, 46185, Trollhättan, Sweden aut Bergquist Henrik Department of ENT/H&N Surgery, Sahlgrenska University Hospital, University of Gothenburg, Gothenburg, Sweden aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/12(2015-12-01), 3833-3839 0937-4477 272:12<3833 2015 272 405 https://doi.org/10.1007/s00405-015-3696-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-015-3696-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Larsson Helen Department of Otorhinolaryngology, NAL Medical Centre, 46185, Trollhättan, Sweden aut NATIONALLICENCE 700 1- Bergman Karin Department of Otorhinolaryngology, NAL Medical Centre, 46185, Trollhättan, Sweden aut NATIONALLICENCE 700 1- Finizia Caterina Department of ENT/H&N Surgery, Sahlgrenska University Hospital, University of Gothenburg, Gothenburg, Sweden aut NATIONALLICENCE 700 1- Johansson Leif Department of Otorhinolaryngology, Skövde County Hospital, Skövde, Sweden aut NATIONALLICENCE 700 1- Bove Mogens Department of Otorhinolaryngology, NAL Medical Centre, 46185, Trollhättan, Sweden aut NATIONALLICENCE 700 1- Bergquist Henrik Department of ENT/H&N Surgery, Sahlgrenska University Hospital, University of Gothenburg, Gothenburg, Sweden aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/12(2015-12-01), 3833-3839 0937-4477 272:12<3833 2015 272 405