caa a22 4500 606184368 CHVBK 20210128100826.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s00405-014-3453-0 doi (NATIONALLICENCE)springer-10.1007/s00405-014-3453-0 Long-term outcomes of observation for clinically negative central compartment lymph nodes in papillary thyroid carcinoma [Elektronische Daten] [Jie Liu, Zhengang Xu, Zhengjiang Li, Zongmin Zhang, Pingzhang Tang, Shaoyan Liu] The treatment strategy for clinically negative lymph nodes of papillary thyroid carcinoma is controversial. We report the long-term outcomes of a series of cases treated with thyroidectomy without prophylactic central neck dissection. We reviewed 1,397 cases with papillary thyroid carcinoma treated at our institution between 1991 and 2000. One hundred and seventy-two newly diagnosed cases underwent observation for cN0 central neck lymph nodes. Regional recurrence of the ipsilateral side including central compartment and the lateral neck which needs reoperation was considered as key point for analysis. With a mean follow-up of 96.4months (34-204months), the overall 10-year disease-specific and recurrence-free survival rates were 99 and 86%, respectively. The recurrence and reoperation rates of the central compartment were 3% (5/172) and 4% (7/172), respectively. Univariate analysis showed that extrathyroidal extension was associated with regional recurrence (99 vs. 82%; p=0.002). Central compartment observation is safe in cN0 cases with papillary thyroid carcinoma, particularly in those without extrathyroidal extension. Springer-Verlag Berlin Heidelberg, 2014 Lymph nodes dissection nationallicence Papillary carcinoma nationallicence Cervical neoplasm nationallicence Recurrence nationallicence Follow-up studies nationallicence Liu Jie Department of Head and Neck Surgical Oncology, Chinese Academy of Medical Science, Cancer Hospital, Beijing, China aut Xu Zhengang Department of Head and Neck Surgical Oncology, Chinese Academy of Medical Science, Cancer Hospital, Beijing, China aut Li Zhengjiang Department of Head and Neck Surgical Oncology, Chinese Academy of Medical Science, Cancer Hospital, Beijing, China aut Zhang Zongmin Department of Head and Neck Surgical Oncology, Chinese Academy of Medical Science, Cancer Hospital, Beijing, China aut Tang Pingzhang Department of Head and Neck Surgical Oncology, Chinese Academy of Medical Science, Cancer Hospital, Beijing, China aut Liu Shaoyan Department of Head and Neck Surgical Oncology, Chinese Academy of Medical Science, Cancer Hospital, Beijing, China aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/12(2015-12-01), 3801-3804 0937-4477 272:12<3801 2015 272 405 https://doi.org/10.1007/s00405-014-3453-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-3453-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Liu Jie Department of Head and Neck Surgical Oncology, Chinese Academy of Medical Science, Cancer Hospital, Beijing, China aut NATIONALLICENCE 700 1- Xu Zhengang Department of Head and Neck Surgical Oncology, Chinese Academy of Medical Science, Cancer Hospital, Beijing, China aut NATIONALLICENCE 700 1- Li Zhengjiang Department of Head and Neck Surgical Oncology, Chinese Academy of Medical Science, Cancer Hospital, Beijing, China aut NATIONALLICENCE 700 1- Zhang Zongmin Department of Head and Neck Surgical Oncology, Chinese Academy of Medical Science, Cancer Hospital, Beijing, China aut NATIONALLICENCE 700 1- Tang Pingzhang Department of Head and Neck Surgical Oncology, Chinese Academy of Medical Science, Cancer Hospital, Beijing, China aut NATIONALLICENCE 700 1- Liu Shaoyan Department of Head and Neck Surgical Oncology, Chinese Academy of Medical Science, Cancer Hospital, Beijing, China aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/12(2015-12-01), 3801-3804 0937-4477 272:12<3801 2015 272 405