caa a22 4500 606184376 CHVBK 20210128100826.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s00405-015-3519-7 doi (NATIONALLICENCE)springer-10.1007/s00405-015-3519-7 Surgical treatment for nasal polyposis: predictors of outcome [Elektronische Daten] [Marko Grgić, Hrvoje Ćupić, Livije Kalogjera, Tomislav Baudoin] Nasal polyps recur in approximately one-third of patients after surgical treatment. It would be beneficial to be able to predict the patients in whom we might expect recurrence and to predict the clinical outcome after surgery. The study included 30 patients operated for nasal polyps. Removed polyps were analyzed by immunohistochemical analysis for IL-5, IgE, vascular endothelial growth factor and eosinophilic infiltration. These parameters together with preoperative CT score were used as independent variables, and subjective score improvement after 2years was used as a dependent variable in multiple linear regression analysis. Furthermore, the patients were divided into two groups: low and high polyp tissue immunoreactivity. The Chi-squared test was used to determine whether polyp immunoreactivity influences polyp recurrence and subjective score. Preoperative CT score had a slightly positive correlation with subjective score after 2years. High eosinophil infiltration significantly predicted a higher risk for polyp recurrence. High IL-5 positivity was related to greater risk for polyp recurrence than low IL-5 reactivity but not significantly. IgE and VEGF reactivity in polyp specimens did not have any effect on polyp recurrence. High eosinophilic infiltration in polyps can predict worse outcome after surgical treatment of chronic rhinosinusitis with nasal polyposis. IgE and VEGF do not have prognostic significance to polyp recurrence after surgery. The preoperative extent of disease measured by CT score had a slightly positive correlation with worse outcome after surgery. Springer-Verlag Berlin Heidelberg, 2015 Nasal polyps nationallicence Interleukin-5 nationallicence Vascular endothelial growth factors nationallicence Immunoglobulin E nationallicence Nasal surgical procedures nationallicence CT score nationallicence Eosinophil infiltration nationallicence Grgić Marko Department of ENT and Head and Neck Surgery, ‘Sisters of Mercy' University Medical Center, Zagreb University School of Medicine, Vinogradska 29, Zagreb, Croatia aut Ćupić Hrvoje Department of Pathology, University Hospital ‘Sisters of Mercy' University Medical Center, Zagreb University School of Dentistry, Vinogradska 29, Zagreb, Croatia aut Kalogjera Livije Department of ENT and Head and Neck Surgery, ‘Sisters of Mercy' University Medical Center, Zagreb University School of Medicine, Vinogradska 29, Zagreb, Croatia aut Baudoin Tomislav Department of ENT and Head and Neck Surgery, ‘Sisters of Mercy' University Medical Center, Zagreb University School of Medicine, Vinogradska 29, Zagreb, Croatia aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/12(2015-12-01), 3735-3743 0937-4477 272:12<3735 2015 272 405 https://doi.org/10.1007/s00405-015-3519-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-015-3519-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Grgić Marko Department of ENT and Head and Neck Surgery, ‘Sisters of Mercy' University Medical Center, Zagreb University School of Medicine, Vinogradska 29, Zagreb, Croatia aut NATIONALLICENCE 700 1- Ćupić Hrvoje Department of Pathology, University Hospital ‘Sisters of Mercy' University Medical Center, Zagreb University School of Dentistry, Vinogradska 29, Zagreb, Croatia aut NATIONALLICENCE 700 1- Kalogjera Livije Department of ENT and Head and Neck Surgery, ‘Sisters of Mercy' University Medical Center, Zagreb University School of Medicine, Vinogradska 29, Zagreb, Croatia aut NATIONALLICENCE 700 1- Baudoin Tomislav Department of ENT and Head and Neck Surgery, ‘Sisters of Mercy' University Medical Center, Zagreb University School of Medicine, Vinogradska 29, Zagreb, Croatia aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/12(2015-12-01), 3735-3743 0937-4477 272:12<3735 2015 272 405