caa a22 4500 606184392 CHVBK 20210128100826.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s00405-014-3435-2 doi (NATIONALLICENCE)springer-10.1007/s00405-014-3435-2 Association between XRCC3 Thr241Met polymorphism and laryngeal cancer susceptibility in Turkish population [Elektronische Daten] [Pelin Mutlu, Murad Mutlu, Serap Yalçın, Atılay Yaylacı, Gözde Ünsoy, Güleser Saylam, İstemihan Akın, Ufuk Gündüz, Hakan Korkmaz] DNA repair systems are essential for normal cell function. Genetic alterations in the DNA repair genes such as X-ray repair cross-complementing group 3 (XRCC3), can cause a change in protein activity which results in cancer susceptibility. The aim of this study was to investigate the association of XRCC3 Thr241Met single nucleotide polymorphism (SNP), smoking and alcohol consumption with the risk of laryngeal cancer in Turkish population. The frequencies of Thr241Met SNP were studied in 58 laryngeal cancer cases (SSC) and 67 healthy individuals. Genomic DNA was isolated from peripheral blood samples of both controls and laryngeal cancer cases. Thr241Met SNP was genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The genotype and allele frequencies of Thr241Met polymorphism were not statistically significant between the laryngeal cancer and control groups. Carrying mutant allele was not associated with the risk of laryngeal cancer. On the other hand, smoking and chronic alcohol consumption were associated with the risk of laryngeal cancer but there is no association between Thr241Met, smoking and alcohol consumption in laryngeal cancer cases. These results indicate that Thr241Met polymorphism was not associated with the development of laryngeal cancer in Turkish population. However, it should be kept in mind that the association of a polymorphism with cancer susceptibility can differ due to several factors such as cancer type, selection criteria, ethnic differences and size of the studied population. Springer-Verlag Berlin Heidelberg, 2014 Laryngeal cancer nationallicence SNP nationallicence XRCC3 nationallicence DNA repair nationallicence Mutlu Pelin Central Laboratory, Molecular Biology and Biotechnology R&D, Middle East Technical University, 06800, Ankara, Turkey aut Mutlu Murad Department of Otorhinolaryngology, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey aut Yalçın Serap Department of Food Engineering, Ahi Evran University, Kırşehir, Turkey aut Yaylacı Atılay Department of Otorhinolaryngology, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey aut Ünsoy Gözde Department of Biological Sciences, Middle East Technical University, Ankara, Turkey aut Saylam Güleser Department of Otorhinolaryngology, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey aut Akın İstemihan Department of Otorhinolaryngology, Faculty of Medicine, Kafkas University, Kars, Turkey aut Gündüz Ufuk Department of Biological Sciences, Middle East Technical University, Ankara, Turkey aut Korkmaz Hakan Department of Otorhinolaryngology, Faculty of Medicine, Yıldırım Beyazıt University, Ankara, Turkey aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/12(2015-12-01), 3779-3784 0937-4477 272:12<3779 2015 272 405 https://doi.org/10.1007/s00405-014-3435-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-3435-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mutlu Pelin Central Laboratory, Molecular Biology and Biotechnology R&D, Middle East Technical University, 06800, Ankara, Turkey aut NATIONALLICENCE 700 1- Mutlu Murad Department of Otorhinolaryngology, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey aut NATIONALLICENCE 700 1- Yalçın Serap Department of Food Engineering, Ahi Evran University, Kırşehir, Turkey aut NATIONALLICENCE 700 1- Yaylacı Atılay Department of Otorhinolaryngology, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey aut NATIONALLICENCE 700 1- Ünsoy Gözde Department of Biological Sciences, Middle East Technical University, Ankara, Turkey aut NATIONALLICENCE 700 1- Saylam Güleser Department of Otorhinolaryngology, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey aut NATIONALLICENCE 700 1- Akın İstemihan Department of Otorhinolaryngology, Faculty of Medicine, Kafkas University, Kars, Turkey aut NATIONALLICENCE 700 1- Gündüz Ufuk Department of Biological Sciences, Middle East Technical University, Ankara, Turkey aut NATIONALLICENCE 700 1- Korkmaz Hakan Department of Otorhinolaryngology, Faculty of Medicine, Yıldırım Beyazıt University, Ankara, Turkey aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/12(2015-12-01), 3779-3784 0937-4477 272:12<3779 2015 272 405