caa a22 4500 606184538 CHVBK 20210128100827.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s00405-014-3459-7 doi (NATIONALLICENCE)springer-10.1007/s00405-014-3459-7 Incidence trends in head and neck squamous cell carcinoma in Slovenia, 1983-2009: role of human papillomavirus infection [Elektronische Daten] [Primož Strojan, Vesna Zadnik, Robert Šifrer, Boštjan Lanišnik, Vojislav Didanović, Sara Jereb, Mario Poljak, Boštjan Kocjan, Nina Gale] An increase in the incidence of oropharyngeal squamous cell carcinoma (OPSCC) was observed in several population-based registries and has been attributed to human papillomavirus (HPV) infection. In the present study, we aimed to assess the contribution of HPV infection to the burden of mucosal head and neck squamous cell carcinoma (HNSCC) in Slovenia. For this purpose, data from the nationwide Cancer Registry of Slovenia for cases diagnosed between 1983 and 2009 were analyzed to determine time trends of age-adjusted incidence rates and survival in terms of annual percentage change (APC) for HNSCC in potentially HPV-related and HPV-unrelated sites. In addition, determination of p16 protein, HPV DNA and E6/E7 mRNA was performed in a cohort of OPSCC patients identified from the prospective database for the years 2007-2008. In total, 2,862 cases of HNSCC in potentially HPV-related sites and 7,006 cases in potentially HPV-unrelated sites were identified with decreased incidence observed over the time period in both groups (−0.58; 95% CI −1.28 to −0.13 and −0.90; 95% CI −1.23 to −0.57). Regardless of the group, incidence trends for both genders showed a significant decrease in men and increase in women. In a cohort of 99 OPSCC patients diagnosed between 2007 and 2008, 20 (20.2%) patients had HPV positive tumors and exhibited a superior outcome compared to HPV-negative patients. In conclusion, results of the epidemiologic and histopathologic study confirmed that HPV infection had no major impact on the incidence trends in the Slovenian patients with HNSCC and, specifically, OPSCC during the studied period. Springer-Verlag Berlin Heidelberg, 2014 Head and neck cancer nationallicence Incidence nationallicence Survival nationallicence Squamous cell carcinoma nationallicence Human papillomavirus nationallicence Strojan Primož Department of Radiation Oncology, Institute of Oncology, Zaloška 2, 1000, Ljubljana, Slovenia aut Zadnik Vesna Epidemiology and Cancer Registries, Institute of Oncology Ljubljana, Ljubljana, Slovenia aut Šifrer Robert University Department of Otorhinolaryngology and Cervicofacial Surgery, University Clinical Center Ljubljana, Ljubljana, Slovenia aut Lanišnik Boštjan Department of Otorhinolaryngology, Cervical and Maxillofacial Surgery, University Clinical Center Maribor, Maribor, Slovenia aut Didanović Vojislav Department of Maxillofacial and Oral Surgery, University Clinical Center Ljubljana, Ljubljana, Slovenia aut Jereb Sara Department of Radiation Oncology, Institute of Oncology, Zaloška 2, 1000, Ljubljana, Slovenia aut Poljak Mario Faculty of Medicine, Institute of Microbiology and Immunology, University of Ljubljana, Ljubljana, Slovenia aut Kocjan Boštjan Faculty of Medicine, Institute of Microbiology and Immunology, University of Ljubljana, Ljubljana, Slovenia aut Gale Nina Faculty of Medicine, Institute of Pathology, University of Ljubljana, Ljubljana, Slovenia aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/12(2015-12-01), 3805-3814 0937-4477 272:12<3805 2015 272 405 https://doi.org/10.1007/s00405-014-3459-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-3459-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Strojan Primož Department of Radiation Oncology, Institute of Oncology, Zaloška 2, 1000, Ljubljana, Slovenia aut NATIONALLICENCE 700 1- Zadnik Vesna Epidemiology and Cancer Registries, Institute of Oncology Ljubljana, Ljubljana, Slovenia aut NATIONALLICENCE 700 1- Šifrer Robert University Department of Otorhinolaryngology and Cervicofacial Surgery, University Clinical Center Ljubljana, Ljubljana, Slovenia aut NATIONALLICENCE 700 1- Lanišnik Boštjan Department of Otorhinolaryngology, Cervical and Maxillofacial Surgery, University Clinical Center Maribor, Maribor, Slovenia aut NATIONALLICENCE 700 1- Didanović Vojislav Department of Maxillofacial and Oral Surgery, University Clinical Center Ljubljana, Ljubljana, Slovenia aut NATIONALLICENCE 700 1- Jereb Sara Department of Radiation Oncology, Institute of Oncology, Zaloška 2, 1000, Ljubljana, Slovenia aut NATIONALLICENCE 700 1- Poljak Mario Faculty of Medicine, Institute of Microbiology and Immunology, University of Ljubljana, Ljubljana, Slovenia aut NATIONALLICENCE 700 1- Kocjan Boštjan Faculty of Medicine, Institute of Microbiology and Immunology, University of Ljubljana, Ljubljana, Slovenia aut NATIONALLICENCE 700 1- Gale Nina Faculty of Medicine, Institute of Pathology, University of Ljubljana, Ljubljana, Slovenia aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/12(2015-12-01), 3805-3814 0937-4477 272:12<3805 2015 272 405