caa a22 4500 606184554 CHVBK 20210128100827.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s00405-014-3308-8 doi (NATIONALLICENCE)springer-10.1007/s00405-014-3308-8 Prevalence and risk of malignancy of focal incidental uptake detected by fluorine-18-fluorodeoxyglucose positron emission tomography in the parotid gland: a meta-analysis [Elektronische Daten] [Giorgio Treglia, Francesco Bertagna, Ramin Sadeghi, Barbara Muoio, Luca Giovanella] This study aimed at performing a meta-analysis on the prevalence and risk of malignancy of focal parotid incidental uptake (FPIU) detected by hybrid fluorine-18-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) or 18F-FDG PET alone. A comprehensive literature search of studies published up to July 2014 was performed. Records reporting at least 5 FPIUs were selected. Pooled prevalence and malignancy risk of FPIU were calculated including 95% confidence intervals (95% CI). Twelve records were selected for our meta-analysis. Pooled prevalence of FPIU detected by 18F-FDG PET or PET/CT was 0.6% (95% CI 0.4-0.7%), collecting data of 220 patients with FPIU. Overall, 181 FPIUs underwent further evaluation and 165 FPIUs were pathologically proven. Pooled risk of malignancy was 9.6% (95% CI 5.4-14.8%), 10.9% (95% CI 5.8-17.3%) and 20.4% (95% CI 12.3-30%), considering all FPIUs detected, only those which underwent further evaluation and only those pathologically proven, respectively. Selection bias in the included studies, the heterogeneity among studies and the publication bias are limitations of our meta-analysis. Overall FPIUs are observed in about 1% of 18F-FDG PET or PET/CT scans and they are benign in most of the cases. Nevertheless, further evaluation is needed whenever FPIUs are detected by 18F-FDG-PET or PET/CT to exclude malignant lesions or with possible malignant degeneration. Prospective studies are needed to confirm the findings reported by our meta-analysis. Springer-Verlag Berlin Heidelberg, 2014 Positron emission tomography nationallicence PET/CT nationallicence Fluorine-18-fluorodeoxyglucose nationallicence Parotid nationallicence Incidental nationallicence Meta-analysis nationallicence Treglia Giorgio Department of Nuclear Medicine and PET/CT Centre, Oncology Institute of Southern Switzerland, via Ospedale, 12, 6500, Bellinzona, Switzerland aut Bertagna Francesco Department of Nuclear Medicine, Spedali Civili and University of Brescia, Brescia, Italy aut Sadeghi Ramin Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran aut Muoio Barbara School of Medicine, Catholic University, Rome, Italy aut Giovanella Luca Department of Nuclear Medicine and PET/CT Centre, Oncology Institute of Southern Switzerland, via Ospedale, 12, 6500, Bellinzona, Switzerland aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/12(2015-12-01), 3617-3626 0937-4477 272:12<3617 2015 272 405 https://doi.org/10.1007/s00405-014-3308-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-3308-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Treglia Giorgio Department of Nuclear Medicine and PET/CT Centre, Oncology Institute of Southern Switzerland, via Ospedale, 12, 6500, Bellinzona, Switzerland aut NATIONALLICENCE 700 1- Bertagna Francesco Department of Nuclear Medicine, Spedali Civili and University of Brescia, Brescia, Italy aut NATIONALLICENCE 700 1- Sadeghi Ramin Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran aut NATIONALLICENCE 700 1- Muoio Barbara School of Medicine, Catholic University, Rome, Italy aut NATIONALLICENCE 700 1- Giovanella Luca Department of Nuclear Medicine and PET/CT Centre, Oncology Institute of Southern Switzerland, via Ospedale, 12, 6500, Bellinzona, Switzerland aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/12(2015-12-01), 3617-3626 0937-4477 272:12<3617 2015 272 405