caa a22 4500 606184651 CHVBK 20210128100827.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s00405-014-3011-9 doi (NATIONALLICENCE)springer-10.1007/s00405-014-3011-9 Transoral laser microsurgery for early and moderately advanced laryngeal cancers: outcomes from a single centralised United Kingdom centre [Elektronische Daten] [Mark Wilkie, Kathryn Lightbody, Daniel Lythgoe, Sankalap Tandon, Jeffrey Lancaster, Terrence Jones] Transoral laser microsurgery (TLM) represents an important treatment for selected laryngeal cancers. Utilisation of TLM, however, is highly variable between United Kingdom (UK) centres, and published data relating to its use in the UK is scarce. We report outcomes from our tertiary referral centre, and highlight lessons learned. Patients undergoing primary TLM for laryngeal cancer with curative intent (2007-2011) were studied retrospectively. Survival analyses were evaluated using the Kaplan-Meier method and log-rank statistics used to examine the influence of several variables. Overall, 170 cases were included—153 glottic and 17 supraglottic. Median follow-up was 39months (range 14-79months). Respective 3-year local control (LC), overall survival (OS), disease-specific survival (DSS), and disease-free survival were 92, 92, 98, and 86% for glottic carcinomas. Three-year LC and OS were both 88% for supraglottic carcinomas. For glottic cases, a significant impact of pT stage on DSS was observed, and of age on OS. Median hospital stay was one and 19days for glottic and supraglottic cases respectively, with respective 3-year laryngeal preservation rates of 97 and 94%, and tracheostomy rates of 0 and 29%. One patient in the glottic group and four in the supraglottic group failed to regain swallowing function post-operatively, remaining either PEG dependent or undergoing functional total laryngectomy. Our series confirms the oncological and functional efficacy of TLM, offering a unique large-scale UK perspective. Our experience indicates, however, that treatment of larger supraglottic tumours should be considered carefully, as functional outcomes may be compromised. Springer-Verlag Berlin Heidelberg, 2014 Carcinoma nationallicence Squamous cell/surgery nationallicence Laryngeal neoplasms/surgery nationallicence Laser nationallicence Therapy/methods nationallicence Laryngeal neoplasms/mortality nationallicence Neoplasm recurrence nationallicence Local nationallicence Survival analysis nationallicence Wilkie Mark Department of Otorhinolaryngology-Head and Neck Surgery, University Hospital Aintree, Lower Lane, L9 7AL, Liverpool, UK aut Lightbody Kathryn Department of Otorhinolaryngology-Head and Neck Surgery, University Hospital Aintree, Lower Lane, L9 7AL, Liverpool, UK aut Lythgoe Daniel Department of Medical Statistics, Liverpool Cancer Trials Unit, University of Liverpool, Waterhouse Building, Brownlow Street, L69 3GL, Liverpool, UK aut Tandon Sankalap Department of Otorhinolaryngology-Head and Neck Surgery, University Hospital Aintree, Lower Lane, L9 7AL, Liverpool, UK aut Lancaster Jeffrey Department of Otorhinolaryngology-Head and Neck Surgery, University Hospital Aintree, Lower Lane, L9 7AL, Liverpool, UK aut Jones Terrence Department of Otorhinolaryngology-Head and Neck Surgery, University Hospital Aintree, Lower Lane, L9 7AL, Liverpool, UK aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/3(2015-03-01), 695-704 0937-4477 272:3<695 2015 272 405 https://doi.org/10.1007/s00405-014-3011-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-3011-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wilkie Mark Department of Otorhinolaryngology-Head and Neck Surgery, University Hospital Aintree, Lower Lane, L9 7AL, Liverpool, UK aut NATIONALLICENCE 700 1- Lightbody Kathryn Department of Otorhinolaryngology-Head and Neck Surgery, University Hospital Aintree, Lower Lane, L9 7AL, Liverpool, UK aut NATIONALLICENCE 700 1- Lythgoe Daniel Department of Medical Statistics, Liverpool Cancer Trials Unit, University of Liverpool, Waterhouse Building, Brownlow Street, L69 3GL, Liverpool, UK aut NATIONALLICENCE 700 1- Tandon Sankalap Department of Otorhinolaryngology-Head and Neck Surgery, University Hospital Aintree, Lower Lane, L9 7AL, Liverpool, UK aut NATIONALLICENCE 700 1- Lancaster Jeffrey Department of Otorhinolaryngology-Head and Neck Surgery, University Hospital Aintree, Lower Lane, L9 7AL, Liverpool, UK aut NATIONALLICENCE 700 1- Jones Terrence Department of Otorhinolaryngology-Head and Neck Surgery, University Hospital Aintree, Lower Lane, L9 7AL, Liverpool, UK aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/3(2015-03-01), 695-704 0937-4477 272:3<695 2015 272 405