caa a22 4500 606184732 CHVBK 20210128100828.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s00405-014-3017-3 doi (NATIONALLICENCE)springer-10.1007/s00405-014-3017-3 Radiotherapy for head and neck cancer in nonagenarian patients: a possible cornerstone? [Elektronische Daten] [Romain Rivoirard, Coralie Moncharmont, Avi Assouline, Pierre Auberdiac, Benoite Mery, Alexander Falk, Pierre Annède, Jane-Chloé Trone, Jean-Baptiste Guy, Nicolas Vial, Pierre Fournel, Yacine Merrouche, Cyrus Chargari, Nicolas Magné] In the field of radiotherapy, there is very little scientific data on the management of nonagenarians, especially in patients aged 90years or more and with head and neck cancer (HNC). We made one of the first retrospective study of the feasibility and safety of radiotherapy in this population with HNC. Records of radiotherapy coming from four health facilities were studied to include all nonagenarian patients with HNC in the last 10years and who received radiation therapy. We analyzed patient characteristics and primary cancers, as well as objective of the treatment (curative or palliative), efficacy and toxicity. Twenty patients receiving radiotherapy were identified; mean age was 93.2years (standard deviation 2.8). Treatment was given with curative and palliative intent in 40 and 60% of cases, respectively. The most common primary tumors were tumors of the salivary glands (30% of cases), oral cavity tumors (25% of cases) and thyroid tumors (15% of cases). Median total prescribed dose was 47.5Gy (12-70Gy). Median number of delivered fractions was 18.5 (2-35 fractions). All patients received intensive supportive care during radiotherapy. Toxicities were mild to moderate. Radiotherapy could not be completed for four patients (20% of cases). One patient developed grade 1-2 delayed toxicities. At the last follow-up, only four patients (20% of cases) were alive. Cancer was cause of death in most cases. Radiotherapy may be performed for the nonagenarians with HNC. The total dose and fractionation must be adjusted to optimize the tolerance. However, the prognosis remains very poor, cancer being the main cause of death. Research of geriatric vulnerabilities prior to any treatment, in the context of a comprehensive geriatric assessment, is still recommended to select patients for radiotherapy. Springer-Verlag Berlin Heidelberg, 2014 Head and neck cancer nationallicence Nonagenarian nationallicence Radiotherapy nationallicence Rivoirard Romain Department of Medical Oncology, Institut Lucien Neuwirth, St Priest en Jarez Cedex, France aut Moncharmont Coralie Département de Radiothérapie, Institut de Cancérologie Lucien Neuwirth, 108 bis, avenue Albert Raimond, BP 60008, 42271, St Priest en Jarez cedex, France aut Assouline Avi Department of Radiotherapy, Clinical Center of Porte de Saint Cloud, Boulogne-Billancourt, France aut Auberdiac Pierre Department of Radiotherapy, Clinique Claude Bernard, Albi, France aut Mery Benoite Department of Medical Oncology, Institut Lucien Neuwirth, St Priest en Jarez Cedex, France aut Falk Alexander Department of Radiotherapy, Centre Antoine Lacassagne, Nice, France aut Annède Pierre Department of Radiotherapy, Instruction Armed Val-de-Grace Hospital, 75230, Paris, France aut Trone Jane-Chloé Département de Radiothérapie, Institut de Cancérologie Lucien Neuwirth, 108 bis, avenue Albert Raimond, BP 60008, 42271, St Priest en Jarez cedex, France aut Guy Jean-Baptiste Département de Radiothérapie, Institut de Cancérologie Lucien Neuwirth, 108 bis, avenue Albert Raimond, BP 60008, 42271, St Priest en Jarez cedex, France aut Vial Nicolas Département de Radiothérapie, Institut de Cancérologie Lucien Neuwirth, 108 bis, avenue Albert Raimond, BP 60008, 42271, St Priest en Jarez cedex, France aut Fournel Pierre Department of Medical Oncology, Institut Lucien Neuwirth, St Priest en Jarez Cedex, France aut Merrouche Yacine Department of Medical Oncology, Institut Lucien Neuwirth, St Priest en Jarez Cedex, France aut Chargari Cyrus Department of Radiotherapy, Instruction Armed Val-de-Grace Hospital, 75230, Paris, France aut Magné Nicolas Département de Radiothérapie, Institut de Cancérologie Lucien Neuwirth, 108 bis, avenue Albert Raimond, BP 60008, 42271, St Priest en Jarez cedex, France aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/3(2015-03-01), 719-725 0937-4477 272:3<719 2015 272 405 https://doi.org/10.1007/s00405-014-3017-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-3017-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rivoirard Romain Department of Medical Oncology, Institut Lucien Neuwirth, St Priest en Jarez Cedex, France aut NATIONALLICENCE 700 1- Moncharmont Coralie Département de Radiothérapie, Institut de Cancérologie Lucien Neuwirth, 108 bis, avenue Albert Raimond, BP 60008, 42271, St Priest en Jarez cedex, France aut NATIONALLICENCE 700 1- Assouline Avi Department of Radiotherapy, Clinical Center of Porte de Saint Cloud, Boulogne-Billancourt, France aut NATIONALLICENCE 700 1- Auberdiac Pierre Department of Radiotherapy, Clinique Claude Bernard, Albi, France aut NATIONALLICENCE 700 1- Mery Benoite Department of Medical Oncology, Institut Lucien Neuwirth, St Priest en Jarez Cedex, France aut NATIONALLICENCE 700 1- Falk Alexander Department of Radiotherapy, Centre Antoine Lacassagne, Nice, France aut NATIONALLICENCE 700 1- Annède Pierre Department of Radiotherapy, Instruction Armed Val-de-Grace Hospital, 75230, Paris, France aut NATIONALLICENCE 700 1- Trone Jane-Chloé Département de Radiothérapie, Institut de Cancérologie Lucien Neuwirth, 108 bis, avenue Albert Raimond, BP 60008, 42271, St Priest en Jarez cedex, France aut NATIONALLICENCE 700 1- Guy Jean-Baptiste Département de Radiothérapie, Institut de Cancérologie Lucien Neuwirth, 108 bis, avenue Albert Raimond, BP 60008, 42271, St Priest en Jarez cedex, France aut NATIONALLICENCE 700 1- Vial Nicolas Département de Radiothérapie, Institut de Cancérologie Lucien Neuwirth, 108 bis, avenue Albert Raimond, BP 60008, 42271, St Priest en Jarez cedex, France aut NATIONALLICENCE 700 1- Fournel Pierre Department of Medical Oncology, Institut Lucien Neuwirth, St Priest en Jarez Cedex, France aut NATIONALLICENCE 700 1- Merrouche Yacine Department of Medical Oncology, Institut Lucien Neuwirth, St Priest en Jarez Cedex, France aut NATIONALLICENCE 700 1- Chargari Cyrus Department of Radiotherapy, Instruction Armed Val-de-Grace Hospital, 75230, Paris, France aut NATIONALLICENCE 700 1- Magné Nicolas Département de Radiothérapie, Institut de Cancérologie Lucien Neuwirth, 108 bis, avenue Albert Raimond, BP 60008, 42271, St Priest en Jarez cedex, France aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/3(2015-03-01), 719-725 0937-4477 272:3<719 2015 272 405