caa a22 4500 606184783 CHVBK 20210128100828.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s00405-014-3333-7 doi (NATIONALLICENCE)springer-10.1007/s00405-014-3333-7 Postoperative irradiation in patients with pT3-4N0 laryngeal cancer: results and prognostic factors [Elektronische Daten] [Tomasz Skóra, Jadwiga Nowak-Sadzikowska, Anna Mucha-Małecka, Bogumiła Szyszka-Charewicz, Jerzy Jakubowicz, Bogdan Gliński] Approximately 60% of patients with locally advanced laryngeal cancer (LALC) treated primarily with surgery require adjuvant radiotherapy. In the available literature predominate series of patients were with pathologically confirmed node-positivestatus. Subgroups of pN0 patients with LALC are scarce. The aim of the study is to evaluate the efficacy of postoperative radiotherapy in patients with pathological stage T3-4N0M0 and identification of prognostic factors in this group. Between 1975 and 2005, 138 patients with squamous pT3-4N0 laryngeal cancer were irradiated postoperatively. Primary surgical treatment consisted of total laryngectomy and cervical lymphadenectomy. The median time between surgery and the implementation of radiotherapy was 56days. The median total dose was 60Gy (range 40-70Gy). Five-year disease-free survival (DFS5) was achieved in 76% of patients. Cancer recurrence was observed in 34 patients. In 28 (82%) cases it was locoregional failure. DFS5 rates for pT3 and pT4 were 92 and 69%, for margin status R0, R1 and R2 were 82, 72 and 67%, respectively. The pharyngeal invasion was related to a decrease in DFS5 from 80 to 59%. Postoperative irradiation in patients with pT3-4N0 LALC is an effective treatment method. The main reason of the failure is local recurrence. The following independent prognostic factors were identified in this group of patients: pT stage, surgical margin status and pharyngeal invasion. The Author(s), 2014 Laryngeal cancer nationallicence Postoperative radiotherapy nationallicence Total laryngectomy nationallicence Prognostic factors nationallicence Skóra Tomasz Oncology Department, Maria Skłodowska-Curie Memorial Institute of Oncology, ul. Garncarska 11, 31-115, Kraków, Poland aut Nowak-Sadzikowska Jadwiga Oncology Department, Maria Skłodowska-Curie Memorial Institute of Oncology, ul. Garncarska 11, 31-115, Kraków, Poland aut Mucha-Małecka Anna Oncology Department, Maria Skłodowska-Curie Memorial Institute of Oncology, ul. Garncarska 11, 31-115, Kraków, Poland aut Szyszka-Charewicz Bogumiła Oncology Department, Maria Skłodowska-Curie Memorial Institute of Oncology, ul. Garncarska 11, 31-115, Kraków, Poland aut Jakubowicz Jerzy Oncology Department, Maria Skłodowska-Curie Memorial Institute of Oncology, ul. Garncarska 11, 31-115, Kraków, Poland aut Gliński Bogdan Oncology Department, Maria Skłodowska-Curie Memorial Institute of Oncology, ul. Garncarska 11, 31-115, Kraków, Poland aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/3(2015-03-01), 673-679 0937-4477 272:3<673 2015 272 405 https://doi.org/10.1007/s00405-014-3333-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-3333-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Skóra Tomasz Oncology Department, Maria Skłodowska-Curie Memorial Institute of Oncology, ul. Garncarska 11, 31-115, Kraków, Poland aut NATIONALLICENCE 700 1- Nowak-Sadzikowska Jadwiga Oncology Department, Maria Skłodowska-Curie Memorial Institute of Oncology, ul. Garncarska 11, 31-115, Kraków, Poland aut NATIONALLICENCE 700 1- Mucha-Małecka Anna Oncology Department, Maria Skłodowska-Curie Memorial Institute of Oncology, ul. Garncarska 11, 31-115, Kraków, Poland aut NATIONALLICENCE 700 1- Szyszka-Charewicz Bogumiła Oncology Department, Maria Skłodowska-Curie Memorial Institute of Oncology, ul. Garncarska 11, 31-115, Kraków, Poland aut NATIONALLICENCE 700 1- Jakubowicz Jerzy Oncology Department, Maria Skłodowska-Curie Memorial Institute of Oncology, ul. Garncarska 11, 31-115, Kraków, Poland aut NATIONALLICENCE 700 1- Gliński Bogdan Oncology Department, Maria Skłodowska-Curie Memorial Institute of Oncology, ul. Garncarska 11, 31-115, Kraków, Poland aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/3(2015-03-01), 673-679 0937-4477 272:3<673 2015 272 405