caa a22 4500 606184856 CHVBK 20210128100828.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s00405-014-3130-3 doi (NATIONALLICENCE)springer-10.1007/s00405-014-3130-3 ADAM33 polymorphisms and susceptibility to allergic rhinitis: a meta-analysis [Elektronische Daten] [Yu Xu, Ji-Xiang Zhang] Abstract : Several polymorphisms in a disintegrin and metalloproteinase 33 (ADAM33) have been implicated in susceptibility to allergic rhinitis (AR), but the results are inconclusive. This meta-analysis was aimed to clarify the impact of ADAM33 polymorphisms on AR risk. Pubmed, EMBASE and Cochrane library were searched until 11 October 2013 for eligible studies on seven ADAM33 polymorphisms: T1, T2, S1, S2, V4, Q−1 and T+1. Data were extracted, and pooled odd ratios (ORs) as well as 95% confidence intervals (CIs) were calculated. Six studies with 1,135 AR patients and 1,565 controls were included. It was found that ADAM33 T1 (AG+GG vs. AA, OR1.47, 95% CI 1.23-1.75, I 2=94%; G vs. A, OR1.53, 95% CI 1.32-1.78, I 2=94%), T2 (GA+AA vs. GG, OR1.26, 95% CI 1.06-1.51, I 2=92%; G vs. A, OR1.27, 95% CI 1.08-1.50, I 2=92%), V4 (CG+GG vs. CC OR1.35, 95% CI 1.14-1.59, I 2=95%;G vs. C OR1.28, 95% CI 1.13-1.44, I 2=96%) and Q−1 (GA+AA vs. GG OR1.55, 95% CI 1.24-1.95, I 2=74%; G vs. C OR1.46, 95% CI 1.19-1.79, I 2=73%) polymorphisms were significantly associated with AR susceptibility but not S1, S2 and T+1. In Asians, the same result was found. This meta-analysis indicated that ADAM33 T1, T2, V4 and Q−1 polymorphisms may be the risk factors which conferred to AR susceptibility. The differences in ethnicity did not influence the associations obviously. Gene-gene and gene-environment interactions should be investigated in the future. Springer-Verlag Berlin Heidelberg, 2014 ADAM33 nationallicence Polymorphisms nationallicence Allergic rhinitis nationallicence Meta-analysis nationallicence Xu Yu Department of Otolaryngology, Renmin Hospital of Wuhan University, 430060, Wuhan, Hubei Province, China aut Zhang Ji-Xiang Department of Gastroenterology, Renmin Hospital of Wuhan University, 430060, Wuhan, Hubei Province, China aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/3(2015-03-01), 597-605 0937-4477 272:3<597 2015 272 405 https://doi.org/10.1007/s00405-014-3130-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-3130-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Xu Yu Department of Otolaryngology, Renmin Hospital of Wuhan University, 430060, Wuhan, Hubei Province, China aut NATIONALLICENCE 700 1- Zhang Ji-Xiang Department of Gastroenterology, Renmin Hospital of Wuhan University, 430060, Wuhan, Hubei Province, China aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/3(2015-03-01), 597-605 0937-4477 272:3<597 2015 272 405