caa a22 4500 606184929 CHVBK 20210128100829.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s00405-014-3009-3 doi (NATIONALLICENCE)springer-10.1007/s00405-014-3009-3 Survivin expression correlates with nodal metastasis in T1-T2 squamous cell carcinoma of the tongue [Elektronische Daten] [Murat Doğan, Sedat Çağlı, İmdat Yüce, Ali Bayram, Mehmet Somdaş, Duran Karataş, Mehmet Cihan, Fatih Yüksel, Ercihan Güney] In this study, the correlation between neck metastasis and recurrence was investigated by studying specimens of tongue squamous cell carcinoma patients immunohistochemical with survivin antibodies in the primary biopsy. A retrospective review was conducted at the Academic University Hospital. 46 patients who had squamous cell carcinoma of the tongue, who underwent various types of glossectomy and neck dissections between 1991 and 2008, were evaluated. The patient's sex, TNM staging, differentiation and recurrence rates were analyzed. There were 20 T1 patients and 26 T2 patients; 27 of the patients were N0 and 19 had metastatic lymph nodes in the neck. Survivin antibodies were applied with streptavidin-biotin method to the sections that were prepared from the primary tumor biopsy specimens of the patients. The correlation between neck metastasis and recurrence and survivins' immunohistochemical staining was analyzed with statistical methods. There were no significant differences between the patient's age, sex, tumor's T stage, tumor differentiation and survivin staining density. Survivin staining was positive in 15 (79%) of 19 patients with neck metastasis, while it was positive in 16 (59%) of 27 patients without neck metastasis. Eleven (79%) of the 14 patients who had recurrence and all 6 patients who had neck recurrence only were stained by survivin. Expression of nuclear and cytoplasmic survivin can be a useful marker for predicting cervical lymph node metastasis in T1-T2 tumors in tongue SCC. Springer-Verlag Berlin Heidelberg, 2014 Apoptosis nationallicence Squamous cell carcinoma nationallicence Survivin nationallicence Tongue nationallicence Doğan Murat Research and Traınıng Hospital, Kayseri, Turkey aut Çağlı Sedat Department of Otolaryngology, Ünivercity of Erciyes, Kayseri, Turkey aut Yüce İmdat Department of Otolaryngology, Ünivercity of Erciyes, Kayseri, Turkey aut Bayram Ali Research and Traınıng Hospital, Kayseri, Turkey aut Somdaş Mehmet Research and Traınıng Hospital, Kayseri, Turkey aut Karataş Duran Ear Nose Throat, Melikgazi Medıcal Center, Kayseri, Turkey aut Cihan Mehmet Ibni sina Medical Center, Kayseri, Turkey aut Yüksel Fatih Department of Ear Nose Throat Clinics, Antep State Hospital, Isparta, Turkey aut Güney Ercihan Department of Otolaryngology, Ünivercity of Erciyes, Kayseri, Turkey aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/3(2015-03-01), 689-694 0937-4477 272:3<689 2015 272 405 https://doi.org/10.1007/s00405-014-3009-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-3009-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Doğan Murat Research and Traınıng Hospital, Kayseri, Turkey aut NATIONALLICENCE 700 1- Çağlı Sedat Department of Otolaryngology, Ünivercity of Erciyes, Kayseri, Turkey aut NATIONALLICENCE 700 1- Yüce İmdat Department of Otolaryngology, Ünivercity of Erciyes, Kayseri, Turkey aut NATIONALLICENCE 700 1- Bayram Ali Research and Traınıng Hospital, Kayseri, Turkey aut NATIONALLICENCE 700 1- Somdaş Mehmet Research and Traınıng Hospital, Kayseri, Turkey aut NATIONALLICENCE 700 1- Karataş Duran Ear Nose Throat, Melikgazi Medıcal Center, Kayseri, Turkey aut NATIONALLICENCE 700 1- Cihan Mehmet Ibni sina Medical Center, Kayseri, Turkey aut NATIONALLICENCE 700 1- Yüksel Fatih Department of Ear Nose Throat Clinics, Antep State Hospital, Isparta, Turkey aut NATIONALLICENCE 700 1- Güney Ercihan Department of Otolaryngology, Ünivercity of Erciyes, Kayseri, Turkey aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/3(2015-03-01), 689-694 0937-4477 272:3<689 2015 272 405