caa a22 4500 606185054 CHVBK 20210128100829.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s00405-014-3286-x doi (NATIONALLICENCE)springer-10.1007/s00405-014-3286-x Influence of the vocal cord mobility in salvage surgery after radiotherapy for early-stage squamous cell carcinoma of the glottic larynx [Elektronische Daten] [Philippe Gorphe, Pierre Blanchard, Stephane Temam, François Janot] Disease relapses occur in up to 40% of cases after radiotherapy (RT) for early-stage glottic laryngeal neoplasms, and the foremost remaining treatment option is salvage total laryngectomy (STL). Our objectives were to review the outcomes of patients treated with salvage surgery after RT for early-stage carcinoma of the glottic larynx and to assess prognostic factors. We retrospectively analyzed 43 patients who underwent surgery. Overall and disease-free survival rates among subgroups were calculated and compared, stratified by preoperative stage, vocal cord mobility and postoperative histopathologic data. Recurrences occurred 22.7months after the end of RT. Surgery was STL in 33 cases (76.8%). The main prognostic factors associated with survival rates were initial vocal cord mobility, vocal cord mobility at the diagnosis of recurrence, and changes in mobility. Vocal cord mobility is an important clinical criterion in treatment decision making for early-stage glottis carcinoma and remains important during follow-up. Springer-Verlag Berlin Heidelberg, 2014 Laryngeal carcinoma nationallicence Radiotherapy nationallicence Recurrence nationallicence Laryngeal surgery nationallicence Vocal cord mobility nationallicence Gorphe Philippe Département de Cancérologie Cervico-Faciale, Institut Gustave Roussy, 104 rue Edouard Vaillant, 94805, Villejuif, France aut Blanchard Pierre Département de Radiothérapie, Institut Gustave Roussy, 94805, Villejuif, France aut Temam Stephane Département de Cancérologie Cervico-Faciale, Institut Gustave Roussy, 104 rue Edouard Vaillant, 94805, Villejuif, France aut Janot François Département de Cancérologie Cervico-Faciale, Institut Gustave Roussy, 104 rue Edouard Vaillant, 94805, Villejuif, France aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/10(2015-10-01), 3013-3018 0937-4477 272:10<3013 2015 272 405 https://doi.org/10.1007/s00405-014-3286-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-3286-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gorphe Philippe Département de Cancérologie Cervico-Faciale, Institut Gustave Roussy, 104 rue Edouard Vaillant, 94805, Villejuif, France aut NATIONALLICENCE 700 1- Blanchard Pierre Département de Radiothérapie, Institut Gustave Roussy, 94805, Villejuif, France aut NATIONALLICENCE 700 1- Temam Stephane Département de Cancérologie Cervico-Faciale, Institut Gustave Roussy, 104 rue Edouard Vaillant, 94805, Villejuif, France aut NATIONALLICENCE 700 1- Janot François Département de Cancérologie Cervico-Faciale, Institut Gustave Roussy, 104 rue Edouard Vaillant, 94805, Villejuif, France aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/10(2015-10-01), 3013-3018 0937-4477 272:10<3013 2015 272 405