caa a22 4500 606185062 CHVBK 20210128100829.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s00405-014-3207-z doi (NATIONALLICENCE)springer-10.1007/s00405-014-3207-z Preventing amikacin related ototoxicity with N -acetylcysteine in patients undergoing peritoneal dialysis [Elektronische Daten] [Ismail Kocyigit, Alperen Vural, Aydin Unal, Murat Sipahioglu, Hasan Yucel, Samet Aydemir, Cevat Yazici, M. İlhan Sahin, Oktay Oymak, Bulent Tokgoz] Amikacin is a frequently used antibiotic in the treatment of peritoneal dialysis (PD)-related peritonitis. Ototoxicity is a well-known complication of amikacin for which increased oxidative stress and free oxygen radicals are thought to be responsible. In this study, the effect of N-acetyl-cysteine (NAC) on cochlear function and oxidant situation in the amikacin related ototoxicity in PD-related peritonitis patients are investigated. Forty-six patients who had their first PD-related peritonitis attacks receiving empirical amikacin treatment were enrolled in the study. The patients were randomized into two groups; the first group (n=23) as NAC receiving and the second group (n=23) as a placebo receiving, control group. Otoacoustic emissions were measured before, 1week after and 4weeks after the treatment. Oxidative stress measurements were performed concurrently in order to evaluate the effectiveness of NAC. The results of screening with otoacoustic emission testing after amikacin treatment showed that cochlear function is protected especially in higher frequencies in NAC group when compared with the control group. Evaluation of the antioxidant status of the two groups showed no differences in the basal values, but at the first week there was an increase in the NAC group compared with the control group, and this increase became significant at the fourth week. NAC is found to be safe and effective in amikacin-related ototoxicity in patients with PD-related peritonitis. We suggest a close monitoring of the patients receiving amikacin containing treatment protocols and if amikacin is administrated supplementing the treatment with NAC. Springer-Verlag Berlin Heidelberg, 2014 Amikacin nationallicence Intraperitoneal treatment nationallicence N -acetyl-cysteine nationallicence Otoacoustic emissions nationallicence Ototoxicity nationallicence Kocyigit Ismail Department of Nephrology, Erciyes University Medical Faculty, 38039, Kayseri, Turkey aut Vural Alperen Department of Otolaryngology, Uzunköprü State Hospital, Edirne, Turkey aut Unal Aydin Department of Nephrology, Erciyes University Medical Faculty, 38039, Kayseri, Turkey aut Sipahioglu Murat Department of Nephrology, Erciyes University Medical Faculty, 38039, Kayseri, Turkey aut Yucel Hasan Department of Internal Medicine, Erciyes University Medical Faculty, Kayseri, Turkey aut Aydemir Samet Department of Otolaryngology, Erciyes University Medical Faculty, Kayseri, Turkey aut Yazici Cevat Department of Biochemistry, Erciyes University Medical Faculty, Kayseri, Turkey aut İlhan Sahin M. Department of Otolaryngology, Erciyes University Medical Faculty, Kayseri, Turkey aut Oymak Oktay Department of Nephrology, Erciyes University Medical Faculty, 38039, Kayseri, Turkey aut Tokgoz Bulent Department of Nephrology, Erciyes University Medical Faculty, 38039, Kayseri, Turkey aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/10(2015-10-01), 2611-2620 0937-4477 272:10<2611 2015 272 405 https://doi.org/10.1007/s00405-014-3207-z text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-3207-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kocyigit Ismail Department of Nephrology, Erciyes University Medical Faculty, 38039, Kayseri, Turkey aut NATIONALLICENCE 700 1- Vural Alperen Department of Otolaryngology, Uzunköprü State Hospital, Edirne, Turkey aut NATIONALLICENCE 700 1- Unal Aydin Department of Nephrology, Erciyes University Medical Faculty, 38039, Kayseri, Turkey aut NATIONALLICENCE 700 1- Sipahioglu Murat Department of Nephrology, Erciyes University Medical Faculty, 38039, Kayseri, Turkey aut NATIONALLICENCE 700 1- Yucel Hasan Department of Internal Medicine, Erciyes University Medical Faculty, Kayseri, Turkey aut NATIONALLICENCE 700 1- Aydemir Samet Department of Otolaryngology, Erciyes University Medical Faculty, Kayseri, Turkey aut NATIONALLICENCE 700 1- Yazici Cevat Department of Biochemistry, Erciyes University Medical Faculty, Kayseri, Turkey aut NATIONALLICENCE 700 1- İlhan Sahin M. Department of Otolaryngology, Erciyes University Medical Faculty, Kayseri, Turkey aut NATIONALLICENCE 700 1- Oymak Oktay Department of Nephrology, Erciyes University Medical Faculty, 38039, Kayseri, Turkey aut NATIONALLICENCE 700 1- Tokgoz Bulent Department of Nephrology, Erciyes University Medical Faculty, 38039, Kayseri, Turkey aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/10(2015-10-01), 2611-2620 0937-4477 272:10<2611 2015 272 405