caa a22 4500 606185070 CHVBK 20210128100830.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s00405-014-3224-y doi (NATIONALLICENCE)springer-10.1007/s00405-014-3224-y Role of near-infrared fluorescence imaging in head and neck cancer surgery: from animal models to humans [Elektronische Daten] [Ihab Atallah, Clément Milet, Jean-Luc Coll, Emile Reyt, Christian Righini, Amandine Hurbin] Complete resection of head and neck cancers with negative surgical margins improves the prognosis of the disease and decreases the recurrence rate. Near-infrared fluorescence-guided surgery of head and neck cancer is a rapidly evolving field that represents an invaluable tool for tumor detection and resection. Here, we present a literature review of the principles of near-infrared fluorescence imaging and its use in head and neck cancer surgery. We discuss important studies in both animal models and humans that have been carried out up to this point. We also outline the important fluorescent molecules and devices used in head and neck fluorescence imaging-guided surgery. Although near-infrared fluorescence-guided surgery for head and neck cancers showed efficacy in animal models, its use in humans is limited by the small number of fluorescent probes that are approved for clinical use. However, it is considered as a novel surgical aid that helps delineate tumor margins preoperatively and could spare patients from the added morbidity that is associated with additional surgery or chemoradiation. In addition, it is a useful tool to detect sentinel lymph nodes as well as metastatic lymph nodes. Springer-Verlag Berlin Heidelberg, 2014 Head and neck cancer nationallicence Near-infrared fluorescence imaging nationallicence Surgical margin nationallicence Sentinel lymph nodes nationallicence Fluorescent probes nationallicence Indocyanine green nationallicence Orthotopic animal models nationallicence Atallah Ihab Albert Bonniot Institute, CRI INSERM/UJF U823, BP170, 38042, Grenoble Cedex 9, France aut Milet Clément Albert Bonniot Institute, CRI INSERM/UJF U823, BP170, 38042, Grenoble Cedex 9, France aut Coll Jean-Luc Albert Bonniot Institute, CRI INSERM/UJF U823, BP170, 38042, Grenoble Cedex 9, France aut Reyt Emile Joseph Fourier University, 621 Avenue Centrale, 38041, Saint-Martin-d'Hères, France aut Righini Christian Albert Bonniot Institute, CRI INSERM/UJF U823, BP170, 38042, Grenoble Cedex 9, France aut Hurbin Amandine Albert Bonniot Institute, CRI INSERM/UJF U823, BP170, 38042, Grenoble Cedex 9, France aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/10(2015-10-01), 2593-2600 0937-4477 272:10<2593 2015 272 405 https://doi.org/10.1007/s00405-014-3224-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-3224-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Atallah Ihab Albert Bonniot Institute, CRI INSERM/UJF U823, BP170, 38042, Grenoble Cedex 9, France aut NATIONALLICENCE 700 1- Milet Clément Albert Bonniot Institute, CRI INSERM/UJF U823, BP170, 38042, Grenoble Cedex 9, France aut NATIONALLICENCE 700 1- Coll Jean-Luc Albert Bonniot Institute, CRI INSERM/UJF U823, BP170, 38042, Grenoble Cedex 9, France aut NATIONALLICENCE 700 1- Reyt Emile Joseph Fourier University, 621 Avenue Centrale, 38041, Saint-Martin-d'Hères, France aut NATIONALLICENCE 700 1- Righini Christian Albert Bonniot Institute, CRI INSERM/UJF U823, BP170, 38042, Grenoble Cedex 9, France aut NATIONALLICENCE 700 1- Hurbin Amandine Albert Bonniot Institute, CRI INSERM/UJF U823, BP170, 38042, Grenoble Cedex 9, France aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/10(2015-10-01), 2593-2600 0937-4477 272:10<2593 2015 272 405