caa a22 4500 606185208 CHVBK 20210128100830.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s00405-014-3187-z doi (NATIONALLICENCE)springer-10.1007/s00405-014-3187-z A comparison of inner ear imaging features at different time points of sudden sensorineural hearing loss with three-dimensional fluid-attenuated inversion recovery magnetic resonance imaging [Elektronische Daten] [Honglei Zhu, Yongkang Ou, Jia Fu, Ya Zhang, Hao Xiong, Yaodong Xu] It has been reported that about half of patients with sudden sensorineural hearing loss (SSNHL) show high signals in the affected inner ear on three-dimensional, fluid-attenuated inversion recovery magnetic resonance imaging (3D-FLAIR MRI). These signals may reflect minor hemorrhage or an increased concentration of protein in the inner ear, which has passed through blood vessels with increased permeability. Our objective was to compare the positive ratio of the high signal in affected inner ears at different time points to determine the suitable imaging time point for 3D-FLAIR MRI in SSNHL. 3D-FLAIR MRI images were taken at three times, precontrast and approximately 10min and 4h after intravenous injection of a single dose of gadodiamide (Gd) (0.1mmol/kg), in 46 patients with SNHL. We compared the positive findings of the high signals in the inner ear of patients with SNHL as well as the signal intensity ratio (SIR) between the affected cochleae and unaffected cochleae at three time points. The positive ratios of the high signals in the affected inner ear at the time points of precontrast and 10min and 4h after the intravenous Gd injection were 26.1, 32.6, and 41.3%, respectively. The high signal intensity ratios of affected inner ears at the three time points were 1.28, 1.31, and 1.48, respectively. The difference between the positive ratios precontrast and at 10min after the intravenous Gd injection was statistically significant (P=0.006); the differences between the positive ratios at 4h after the intravenous Gd injection and precontrast and between the ratios at 4h and 10min after the intravenous Gd injection were not statistically significant. The time effects of the median value of SIR were not significant (P=0.064). We do not recommend 4h after intravenous Gd injection as a time point to image the inner ear in SNHL. We believe that imaging precontrast and at 10min after the intravenous Gd injection are suitable time points. Springer-Verlag Berlin Heidelberg, 2014 Sudden hearing loss nationallicence 3D-FLAIR MRI nationallicence Blood-labyrinth barrier nationallicence Zhu Honglei Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China aut Ou Yongkang Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China aut Fu Jia The First People Hospital, Hui Zhou, China aut Zhang Ya Yunnan Tumor Hospital, The Third Affiliated Hospital of Kunming Medical University, Kunming, China aut Xiong Hao Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China aut Xu Yaodong Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/10(2015-10-01), 2659-2665 0937-4477 272:10<2659 2015 272 405 https://doi.org/10.1007/s00405-014-3187-z text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-3187-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zhu Honglei Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China aut NATIONALLICENCE 700 1- Ou Yongkang Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China aut NATIONALLICENCE 700 1- Fu Jia The First People Hospital, Hui Zhou, China aut NATIONALLICENCE 700 1- Zhang Ya Yunnan Tumor Hospital, The Third Affiliated Hospital of Kunming Medical University, Kunming, China aut NATIONALLICENCE 700 1- Xiong Hao Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China aut NATIONALLICENCE 700 1- Xu Yaodong Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/10(2015-10-01), 2659-2665 0937-4477 272:10<2659 2015 272 405