caa a22 4500 606185224 CHVBK 20210128100830.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s00405-014-3283-0 doi (NATIONALLICENCE)springer-10.1007/s00405-014-3283-0 Is there a gender-related susceptibility for cisplatin ototoxicity? [Elektronische Daten] [Günay Kirkim, Yüksel Olgun, Safiye Aktas, Müge Kiray, Efsun Kolatan, Zekiye Altun, Pınar Erçetin, Alper Bagriyanik, Osman Yilmaz, Hülya Ellidokuz] Ototoxicity is a well-known side effect of cisplatin. Some genetic and non-genetic risk factors were described for cisplatin ototoxicity. Although there are some studies which point out a sex-related difference for cisplatin nephrotoxicity and neurotoxicity, sex-related differences for cisplatin ototoxicity have not been studied. The aim of this study is to reveal whether there is any gender-related difference for susceptibility to cisplatin ototoxicity in rats. Fourteen male, 14 female Wistar albino rats were divided into four groups; a female control, a male control, a female cisplatin and a male cisplatin group. Distortion Product Otoacoustic Emission and, Auditory Brainstem Response measurements were obtained. For the cisplatin groups 16mg/kg of cisplatin was applied. On the 4th day audiological examinations were repeated. After killing, cochleae and brainstem tissues were evaluated by light and electron microscopy. The hearing of the female rat cisplatin group was found to have deteriorated more than the hearing of the male rat cisplatin group. Histopathological evaluation revealed more serious damage in the spiral ganglion and brainstem tissues of female rats. Hearing of female rats deteriorated more than the hearing of male rats upon application of cisplatin. This difference in hearing can be attributed to the more severe damage seen in neuronal tissues such as spiral ganglion cells and brainstem neurons. Springer-Verlag Berlin Heidelberg, 2014 Ototoxicity nationallicence Sex nationallicence Cisplatin nationallicence Kirkim Günay School Of Medicine, Department of Otorhinolaryngology, Dokuz Eylül University, Izmir, Turkey aut Olgun Yüksel School Of Medicine, Department of Otorhinolaryngology, Dokuz Eylül University, Izmir, Turkey aut Aktas Safiye School Of Medicine, Department of Basic Oncology, Dokuz Eylül University, Izmir, Turkey aut Kiray Müge School Of Medicine, Department of Physiology, Dokuz Eylül University, Izmir, Turkey aut Kolatan Efsun School Of Medicine, Department of Laboratory Of Animal Science, Dokuz Eylül University, Izmir, Turkey aut Altun Zekiye School Of Medicine, Department of Basic Oncology, Dokuz Eylül University, Izmir, Turkey aut Erçetin Pınar School Of Medicine, Department of Basic Oncology, Dokuz Eylül University, Izmir, Turkey aut Bagriyanik Alper School Of Medicine, Department of Histology, Dokuz Eylül University, Izmir, Turkey aut Yilmaz Osman School Of Medicine, Department of Laboratory Of Animal Science, Dokuz Eylül University, Izmir, Turkey aut Ellidokuz Hülya School Of Medicine, Department of Biostatistics, Dokuz Eylül University, Izmir, Turkey aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/10(2015-10-01), 2755-2763 0937-4477 272:10<2755 2015 272 405 https://doi.org/10.1007/s00405-014-3283-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-3283-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kirkim Günay School Of Medicine, Department of Otorhinolaryngology, Dokuz Eylül University, Izmir, Turkey aut NATIONALLICENCE 700 1- Olgun Yüksel School Of Medicine, Department of Otorhinolaryngology, Dokuz Eylül University, Izmir, Turkey aut NATIONALLICENCE 700 1- Aktas Safiye School Of Medicine, Department of Basic Oncology, Dokuz Eylül University, Izmir, Turkey aut NATIONALLICENCE 700 1- Kiray Müge School Of Medicine, Department of Physiology, Dokuz Eylül University, Izmir, Turkey aut NATIONALLICENCE 700 1- Kolatan Efsun School Of Medicine, Department of Laboratory Of Animal Science, Dokuz Eylül University, Izmir, Turkey aut NATIONALLICENCE 700 1- Altun Zekiye School Of Medicine, Department of Basic Oncology, Dokuz Eylül University, Izmir, Turkey aut NATIONALLICENCE 700 1- Erçetin Pınar School Of Medicine, Department of Basic Oncology, Dokuz Eylül University, Izmir, Turkey aut NATIONALLICENCE 700 1- Bagriyanik Alper School Of Medicine, Department of Histology, Dokuz Eylül University, Izmir, Turkey aut NATIONALLICENCE 700 1- Yilmaz Osman School Of Medicine, Department of Laboratory Of Animal Science, Dokuz Eylül University, Izmir, Turkey aut NATIONALLICENCE 700 1- Ellidokuz Hülya School Of Medicine, Department of Biostatistics, Dokuz Eylül University, Izmir, Turkey aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/10(2015-10-01), 2755-2763 0937-4477 272:10<2755 2015 272 405