caa a22 4500 606185232 CHVBK 20210128100830.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s00405-015-3563-3 doi (NATIONALLICENCE)springer-10.1007/s00405-015-3563-3 Expression of magnesium transporter genes in head and neck cancer patients underwent neoadjuvant cisplatin-based chemotherapy [Elektronische Daten] [Yu-Jung Lin, Fu-Chou Cheng, Li-Sheng Chien, Jin-Ching Lin, Rong-San Jiang, Shih-An Liu] We aimed to investigate expression of magnesium transporter genes in patients with head and neck cancer who underwent cisplatin-based neoadjuvant chemotherapy and their association with serum magnesium level. Head and neck cancer patients scheduled to undergo neoadjuvant cisplatin-based chemotherapy were eligible for enrollment. Blood samples were obtained at three time points: prior to, during, and after completion of chemotherapy. Expression levels of magnesium transporter genes were determined by quantitative real-time PCR. A total of 23 patients were included in the final analysis. The average serum magnesium levels dropped 6.98 and 5.20% during and after completion of chemotherapy. There were neither significant associations between serum magnesium level and demographic variables nor tumor-related variables. SLC41A1 expression level was positively correlated with serum magnesium whereas TRPM6 expression level was negatively correlated with serum magnesium. Serum magnesium level decreased during cisplatin-based chemotherapy in head and neck cancer patients. Further studies are warranted to investigate optimal magnesium measurement and substitution protocol. Springer-Verlag Berlin Heidelberg, 2015 Head-neck cancer nationallicence Magnesium transporter gene nationallicence Cisplatin-based chemotherapy nationallicence Hypomagnesemia nationallicence Lin Yu-Jung Department of Otolaryngology, Taichung Veterans General Hospital, No. 1650, Sec 4, Taiwan Boulevard, Taichung, Taiwan aut Cheng Fu-Chou Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan aut Chien Li-Sheng Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan aut Lin Jin-Ching Department of Radiation Oncology, Taichung Veterans General Hospital, Taichung, Taiwan aut Jiang Rong-San Department of Otolaryngology, Taichung Veterans General Hospital, No. 1650, Sec 4, Taiwan Boulevard, Taichung, Taiwan aut Liu Shih-An Department of Otolaryngology, Taichung Veterans General Hospital, No. 1650, Sec 4, Taiwan Boulevard, Taichung, Taiwan aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/10(2015-10-01), 3051-3057 0937-4477 272:10<3051 2015 272 405 https://doi.org/10.1007/s00405-015-3563-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-015-3563-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lin Yu-Jung Department of Otolaryngology, Taichung Veterans General Hospital, No. 1650, Sec 4, Taiwan Boulevard, Taichung, Taiwan aut NATIONALLICENCE 700 1- Cheng Fu-Chou Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan aut NATIONALLICENCE 700 1- Chien Li-Sheng Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan aut NATIONALLICENCE 700 1- Lin Jin-Ching Department of Radiation Oncology, Taichung Veterans General Hospital, Taichung, Taiwan aut NATIONALLICENCE 700 1- Jiang Rong-San Department of Otolaryngology, Taichung Veterans General Hospital, No. 1650, Sec 4, Taiwan Boulevard, Taichung, Taiwan aut NATIONALLICENCE 700 1- Liu Shih-An Department of Otolaryngology, Taichung Veterans General Hospital, No. 1650, Sec 4, Taiwan Boulevard, Taichung, Taiwan aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/10(2015-10-01), 3051-3057 0937-4477 272:10<3051 2015 272 405