caa a22 4500 606185372 CHVBK 20210128100831.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s00405-014-3305-y doi (NATIONALLICENCE)springer-10.1007/s00405-014-3305-y Vitamin D3 potentiates myelination and recovery after facial nerve injury [Elektronische Daten] [Marion Montava, Stéphane Garcia, Julien Mancini, Yves Jammes, Joël Courageot, Jean-Pierre Lavieille, François Feron] Roles of vitamin D on the immune and nervous systems are increasingly recognized. Two previous studies demonstrated that ergocalciferol (vitamin D2) or cholecalciferol (vitamin D3) induced functional recovery and increased myelination in a rat model of peroneal nerve transection. The current report assessed whether cholecalciferol was efficient in repairing transected rabbit facial nerves. Animals were randomized into two groups of rabbits with an unilateral facial nerve surgery: the vitamin D group included animals receiving a weekly oral bolus of vitamin D3 (200IU/kg/day), from day 1 post-surgery; the control group included animals receiving a weekly oral bolus of vehicle (triglycerides). Contralateral unsectioned facial nerves from all experimental animals were used as controls for the histological study. The facial functional index was measured every week while the inner diameter of myelin sheath and the G ratio were quantified at the end of the 3month experiment. The current report indicates that cholecalciferol significantly increases functional recovery and myelination, after 12weeks of treatment. To the best of our knowledge, this is the first study investigating the therapeutic benefit of vitamin D supplementation in an animal model of facial paralysis. It paves further the way for clinical trials based on the administration of this steroid in individuals with injured facial nerves. Springer-Verlag Berlin Heidelberg, 2014 Facial nerve paralysis nationallicence Rabbit nationallicence Vitamin D3 nationallicence Facial functional index nationallicence Myelination nationallicence Montava Marion Aix Marseille Université, IFSSTAR, LBA, UMR-T 24, 13344, Marseille, France aut Garcia Stéphane Aix Marseille Université, Inserm, U1068, 13288, Marseille, France aut Mancini Julien Aix Marseille Université, Inserm, IRD, UMR_S 912 SESSTIM, 13385, Marseille, France aut Jammes Yves Faculté de Médecine, secteur Nord, Aix Marseille Université et IRBA, UMR MD2, 13916, Marseille, France aut Courageot Joël Faculté de Médecine, secteur Timone, Aix Marseille Université, Service commun de Microscopie Electronique, 13385, Marseille, France aut Lavieille Jean-Pierre Aix Marseille Université, IFSSTAR, LBA, UMR-T 24, 13344, Marseille, France aut Feron François Aix Marseille Université, CNRS, NICN, UMR7259, 13344, Marseille, France aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/10(2015-10-01), 2815-2823 0937-4477 272:10<2815 2015 272 405 https://doi.org/10.1007/s00405-014-3305-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-3305-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Montava Marion Aix Marseille Université, IFSSTAR, LBA, UMR-T 24, 13344, Marseille, France aut NATIONALLICENCE 700 1- Garcia Stéphane Aix Marseille Université, Inserm, U1068, 13288, Marseille, France aut NATIONALLICENCE 700 1- Mancini Julien Aix Marseille Université, Inserm, IRD, UMR_S 912 SESSTIM, 13385, Marseille, France aut NATIONALLICENCE 700 1- Jammes Yves Faculté de Médecine, secteur Nord, Aix Marseille Université et IRBA, UMR MD2, 13916, Marseille, France aut NATIONALLICENCE 700 1- Courageot Joël Faculté de Médecine, secteur Timone, Aix Marseille Université, Service commun de Microscopie Electronique, 13385, Marseille, France aut NATIONALLICENCE 700 1- Lavieille Jean-Pierre Aix Marseille Université, IFSSTAR, LBA, UMR-T 24, 13344, Marseille, France aut NATIONALLICENCE 700 1- Feron François Aix Marseille Université, CNRS, NICN, UMR7259, 13344, Marseille, France aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/10(2015-10-01), 2815-2823 0937-4477 272:10<2815 2015 272 405