caa a22 4500 606185445 CHVBK 20210128100831.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s00405-014-3392-9 doi (NATIONALLICENCE)springer-10.1007/s00405-014-3392-9 Effects of sumatriptan nasal spray (Imigran) on isolated rat's tracheal smooth muscle [Elektronische Daten] [Li-Hsiang Cheng, Pei-Chuan Wu, Shao-Cheng Liu, Feng-Shiang Chiu, Yueng-Hsiang Chu, Ying-Nan Chang, Hsing-Won Wang] Sumatriptan (Imigran) is a potent and highly selective 5-HT1 receptor agonist often used in treating acute migraine. Intranasal sumatriptan is well absorbed and is generally effective in relieving headache. However, the effects of Imigran given intratracheally have rarely been well explored. We aimed to verify the effect of Imigran, which acts on the tracheal smooth muscle directly in vitro. We examined the effectiveness of Imigran on isolated rat tracheal smooth muscle by testing: (1) effect on tracheal smooth muscle resting tension; (2) effect on contraction caused by 10−6M methacholine as a parasympathetic mimetic; (3) effect of the drugs on electrically induced tracheal smooth muscle contractions. The results indicated that the addition of methacholine to the incubation medium caused the trachea to contract in a dose-dependent manner. The addition of Imigran at doses of 10−5M or above elicited a significant relaxation response to 10−6M methacholine-induced contraction. Imigran could inhibit electrical field stimulation-induced spike contraction. It also had a minimal effect on the basal tension of trachea as the concentration increased. The study indicated high concentrations of Imigran could cause bronchodilation to reduce asthma attacks not only by blocking parasympathetic tone, but also by directly antagonizing the effect of cholinergic receptors. Springer-Verlag Berlin Heidelberg, 2014 Imigran nationallicence In vitro study nationallicence Tracheal smooth muscle nationallicence Cheng Li-Hsiang Department of Otolaryngology-Head and Neck Surgery, National Defense Medical Center, Tri-Service General Hospital, Taipei, Taiwan, Republic of China aut Wu Pei-Chuan Department of Psychiatry, Far Eastern Memorial Hospital, New Taipei City, Taiwan, Republic of China aut Liu Shao-Cheng Department of Otolaryngology-Head and Neck Surgery, National Defense Medical Center, Tri-Service General Hospital, Taipei, Taiwan, Republic of China aut Chiu Feng-Shiang Department of Otolaryngology-Head and Neck Surgery, National Defense Medical Center, Tri-Service General Hospital, Taipei, Taiwan, Republic of China aut Chu Yueng-Hsiang Department of Otolaryngology-Head and Neck Surgery, National Defense Medical Center, Tri-Service General Hospital, Taipei, Taiwan, Republic of China aut Chang Ying-Nan Department of Otolaryngology-Head and Neck Surgery, National Defense Medical Center, Tri-Service General Hospital, Taipei, Taiwan, Republic of China aut Wang Hsing-Won Department of Otolaryngology-Head and Neck Surgery, National Defense Medical Center, Tri-Service General Hospital, Taipei, Taiwan, Republic of China aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/10(2015-10-01), 2861-2865 0937-4477 272:10<2861 2015 272 405 https://doi.org/10.1007/s00405-014-3392-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-3392-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cheng Li-Hsiang Department of Otolaryngology-Head and Neck Surgery, National Defense Medical Center, Tri-Service General Hospital, Taipei, Taiwan, Republic of China aut NATIONALLICENCE 700 1- Wu Pei-Chuan Department of Psychiatry, Far Eastern Memorial Hospital, New Taipei City, Taiwan, Republic of China aut NATIONALLICENCE 700 1- Liu Shao-Cheng Department of Otolaryngology-Head and Neck Surgery, National Defense Medical Center, Tri-Service General Hospital, Taipei, Taiwan, Republic of China aut NATIONALLICENCE 700 1- Chiu Feng-Shiang Department of Otolaryngology-Head and Neck Surgery, National Defense Medical Center, Tri-Service General Hospital, Taipei, Taiwan, Republic of China aut NATIONALLICENCE 700 1- Chu Yueng-Hsiang Department of Otolaryngology-Head and Neck Surgery, National Defense Medical Center, Tri-Service General Hospital, Taipei, Taiwan, Republic of China aut NATIONALLICENCE 700 1- Chang Ying-Nan Department of Otolaryngology-Head and Neck Surgery, National Defense Medical Center, Tri-Service General Hospital, Taipei, Taiwan, Republic of China aut NATIONALLICENCE 700 1- Wang Hsing-Won Department of Otolaryngology-Head and Neck Surgery, National Defense Medical Center, Tri-Service General Hospital, Taipei, Taiwan, Republic of China aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/10(2015-10-01), 2861-2865 0937-4477 272:10<2861 2015 272 405