caa a22 4500 606185534 CHVBK 20210128100832.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s00405-014-3235-8 doi (NATIONALLICENCE)springer-10.1007/s00405-014-3235-8 Association between sudden sensorineural hearing loss and anxiety disorder: a population-based study [Elektronische Daten] [Shiu-Dong Chung, Shih-Han Hung, Herng-Ching Lin, Jau-Jiuan Sheu] Anxiety disorder (AD) is commonly associated with a number of physical illnesses. No previous study has investigated the association between AD and sudden sensorineural hearing loss (SSNHL). In this study, we investigated the association between prior AD and SSNHL using a population-based dataset in Taiwan. Sampled subjects of this case-control study were retrieved from the Taiwan "Longitudinal Health Insurance Database”. We identified 3,522 patients who had a diagnosis of SSNHL as cases and 10,566 age- and gender-matched subjects without SSNHL as controls. A conditional logistic regression was used to calculate the odds ratio (OR) for having previously been diagnosed with AD between cases and controls. We found that of 14,088 patients, 13.4% had a prior AD diagnosis, 17.8 and 11.9% for the SSNHL group and controls, respectively. After adjusting for patient socioeconomic characteristics and comorbid medical disorders, SSNHL patients were more likely to have prior AD than the controls (OR 1.49, 95% confidence interval (CI) 1.34-1.66, p<0.001). Furthermore, we found that the significant relationship between SSNHL and prior AD decreased with age. The relationship was the most pronounced among those aged ≤44years, with an adjusted OR of 1.86 (95% CI 1.48-2.33, p<0.001) for cases compared to controls. We concluded that patients with SSNHL had a higher proportion of prior AD than non-SSNHL-diagnosed controls. Further study is needed to confirm our findings and explore the underlying pathomechanisms. Springer-Verlag Berlin Heidelberg, 2014 Anxiety disorder nationallicence Sudden sensorineural hearing loss nationallicence Chung Shiu-Dong Sleep Research Center, Taipei Medical University, Taipei, Taiwan aut Hung Shih-Han Department of Otolaryngology, Taipei Medical University Hospital, Taipei, Taiwan aut Lin Herng-Ching School of Health Care Administration, Taipei Medical University Hospital, Taipei, Taiwan aut Sheu Jau-Jiuan Department of Neurology, School of Medicine, College of Medicine, Taipei Medical University, 250 Wu-Hsing St., 110, Taipei, Taiwan aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/10(2015-10-01), 2673-2678 0937-4477 272:10<2673 2015 272 405 https://doi.org/10.1007/s00405-014-3235-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-3235-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chung Shiu-Dong Sleep Research Center, Taipei Medical University, Taipei, Taiwan aut NATIONALLICENCE 700 1- Hung Shih-Han Department of Otolaryngology, Taipei Medical University Hospital, Taipei, Taiwan aut NATIONALLICENCE 700 1- Lin Herng-Ching School of Health Care Administration, Taipei Medical University Hospital, Taipei, Taiwan aut NATIONALLICENCE 700 1- Sheu Jau-Jiuan Department of Neurology, School of Medicine, College of Medicine, Taipei Medical University, 250 Wu-Hsing St., 110, Taipei, Taiwan aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/10(2015-10-01), 2673-2678 0937-4477 272:10<2673 2015 272 405