caa a22 4500 606185569 CHVBK 20210128100832.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s00405-014-3304-z doi (NATIONALLICENCE)springer-10.1007/s00405-014-3304-z Oral gabapentin and intradermal injection of lidocaine: is there any role in the treatment of moderate/severe tinnitus? [Elektronische Daten] [Francesco Ciodaro, Valentina Mannella, Giovanni Cammaroto, Lilla Bonanno, Francesco Galletti, Bruno Galletti] The objective of our work is to evaluate recovery induced by gabapentin alone and in association with intradermal infiltration of lidocaine in patients affected by moderate/severe tinnitus. Seventy-two patients suffering from moderate/severe unilateral non-pulsatile subjective tinnitus were enrolled. Severity and behaviour of tinnitus were assessed by Tinnitus handicap Index (THI) on the 8th, 22nd and 36th days from onset of therapy, and on the 3rd and 6th month after the end of therapy in patients treated with oral gabapentin (Group I), oral gabapentin and intradermal injection of lidocaine (Group II), and placebo (Group III) Significant differences in THI scores from the 8th day of therapy to the 22nd (p<0.0001) and from the 22nd day to the 36th (p=0.0002 and p=0.0004, respectively) were found in Group I and Group II. In Group II, another relevant decrease of THI scores from the 36th day of therapy to 3months from the end of treatment (p=0.0004) was found. A significant difference in THI scores between Group I and Group II was found after 8days of treatment (p=0.05) with a more relevant decrease registered in Group II; significant differences were also found in THI scores between Group I and Group III after 8days of treatment (p=0.01), with a more relevant decrease registered in Group III; significant differences in THI scores between Group II and Group III were found after 36days of treatment (p=0.009), 3 and 6months after the end of therapy (p=0.005 and p=0.007, respectively), with a more relevant decrease registered in Group II. In conclusion, the use of gabapentin associated to lidocaine seems to be superior to placebo and gabapentin in relieving tinnitus. Springer-Verlag Berlin Heidelberg, 2014 Tinnitus nationallicence Lidocaine nationallicence Gabapentin nationallicence Tinnitus handicap index nationallicence Ciodaro Francesco Department of Otorhinolaryngology, University of Messina, Via Consolare Valeria 1, 98100, Messina, Italy aut Mannella Valentina Department of Otorhinolaryngology, University of Messina, Via Consolare Valeria 1, 98100, Messina, Italy aut Cammaroto Giovanni Department of Otorhinolaryngology, University of Messina, Via Consolare Valeria 1, 98100, Messina, Italy aut Bonanno Lilla IRCCS Centro Neurolesi "Bonino-Pulejo”, Messina, Italy aut Galletti Francesco Department of Otorhinolaryngology, University of Messina, Via Consolare Valeria 1, 98100, Messina, Italy aut Galletti Bruno Department of Otorhinolaryngology, University of Messina, Via Consolare Valeria 1, 98100, Messina, Italy aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/10(2015-10-01), 2825-2830 0937-4477 272:10<2825 2015 272 405 https://doi.org/10.1007/s00405-014-3304-z text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-3304-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ciodaro Francesco Department of Otorhinolaryngology, University of Messina, Via Consolare Valeria 1, 98100, Messina, Italy aut NATIONALLICENCE 700 1- Mannella Valentina Department of Otorhinolaryngology, University of Messina, Via Consolare Valeria 1, 98100, Messina, Italy aut NATIONALLICENCE 700 1- Cammaroto Giovanni Department of Otorhinolaryngology, University of Messina, Via Consolare Valeria 1, 98100, Messina, Italy aut NATIONALLICENCE 700 1- Bonanno Lilla IRCCS Centro Neurolesi "Bonino-Pulejo”, Messina, Italy aut NATIONALLICENCE 700 1- Galletti Francesco Department of Otorhinolaryngology, University of Messina, Via Consolare Valeria 1, 98100, Messina, Italy aut NATIONALLICENCE 700 1- Galletti Bruno Department of Otorhinolaryngology, University of Messina, Via Consolare Valeria 1, 98100, Messina, Italy aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/10(2015-10-01), 2825-2830 0937-4477 272:10<2825 2015 272 405