caa a22 4500 606185585 CHVBK 20210128100832.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s00405-014-3249-2 doi (NATIONALLICENCE)springer-10.1007/s00405-014-3249-2 Clinical implication of computed tomography findings in patients with locally advanced squamous cell carcinoma of the larynx and hypopharynx [Elektronische Daten] [In Ryu, Jeong Lee, Jong-Lyel Roh, Seung-Ho Choi, Soon Nam, Sang Kim, Kyung-Ja Cho] Accurate tumor staging including involvement of laryngeal cartilage is important to treatment planning. Clinicians rely on imaging findings and determine initial laryngectomy for T4-stage cancer with functionless larynx or extralaryngeal spread (ELS). We examined the accuracy and prognostic value of preoperative CT findings for tumor staging in patients with locally advanced laryngeal and hypopharyngeal cancer. Ninety-four consecutive patients with clinically T3-T4-stage squamous cell carcinoma of the larynx or hypopharynx who underwent curative resection of primary tumor were reviewed. Preoperative CT findings were interpreted by a radiologist without pathologic information. Pathologic findings were used as the gold standard for correlating radiographic findings. CT imaging identified 23 (72%) of 32 cases of pathologically documented thyroid cartilage penetration and 24 (73%) of 33 cases of pathologically documented ELS. The positive predictive values for thyroid cartilage penetration and ELS were 70 and 80%, respectively. Pretreatment CT imaging up-staged 6 of 46 pT3 cases and all of 8 pT2 cases, while it down-staged 7 of 40 pT4 cases. The accuracy for clinical staging by CT imaging was 78%. Subglottic extension of the CT image was an independent variable for predicting thyroid cartilage penetration and ELS (P=0.014). Thyroid cartilage penetration with or without ELS on CT scans is significantly associated with unfavorable DFS outcome of patients (P=0.020). CT imaging is suboptimal in diagnosing TCP or ELS of advanced laryngeal cancer, but may be useful to predict patient survival by identifying clinically TCP. Springer-Verlag Berlin Heidelberg, 2014 Laryngectomy nationallicence Squamous cell carcinoma nationallicence Extralaryngeal spread nationallicence Thyroid cartilage nationallicence Computed tomography nationallicence Ryu In Department of Otolaryngology, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, Republic of Korea aut Lee Jeong Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea aut Roh Jong-Lyel Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-Gu, 138-736, Seoul, South Korea aut Choi Seung-Ho Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-Gu, 138-736, Seoul, South Korea aut Nam Soon Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-Gu, 138-736, Seoul, South Korea aut Kim Sang Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-Gu, 138-736, Seoul, South Korea aut Cho Kyung-Ja Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/10(2015-10-01), 2939-2945 0937-4477 272:10<2939 2015 272 405 https://doi.org/10.1007/s00405-014-3249-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-3249-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ryu In Department of Otolaryngology, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, Republic of Korea aut NATIONALLICENCE 700 1- Lee Jeong Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea aut NATIONALLICENCE 700 1- Roh Jong-Lyel Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-Gu, 138-736, Seoul, South Korea aut NATIONALLICENCE 700 1- Choi Seung-Ho Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-Gu, 138-736, Seoul, South Korea aut NATIONALLICENCE 700 1- Nam Soon Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-Gu, 138-736, Seoul, South Korea aut NATIONALLICENCE 700 1- Kim Sang Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-Gu, 138-736, Seoul, South Korea aut NATIONALLICENCE 700 1- Cho Kyung-Ja Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/10(2015-10-01), 2939-2945 0937-4477 272:10<2939 2015 272 405