caa a22 4500 606185623 CHVBK 20210128100832.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s00405-014-3254-5 doi (NATIONALLICENCE)springer-10.1007/s00405-014-3254-5 The prognostic value of immunohistochemical markers for oral tongue squamous cell carcinoma [Elektronische Daten] [Jeong Hwa, Oh Kwon, Jung Park, Seung Woo, Jin Kim, Gyung Ko, Ji Seo, Rock Kim] The objective of the study was to examine the prognostic value of hypoxia-inducible factor-1α (HIF-1α), carbonic anhydrase-IX (CA-IX), cyclooxygenase-2 (COX-2), Ki-67, and erythropoietin receptor in patients with oral tongue squamous cell carcinoma. Immunohistochemical analysis of marker expression was performed on tissue samples from 25 patients with tongue squamous cell carcinoma. The Kaplan-Meier method, univariate and multivariate analyses, and the Cox proportional hazards model were used to examine associations between patient and tumor characteristics, and the immunohistochemical results and disease-specific survival. There was no association between the expression of the five markers and disease-specific survival, and there was no statistically significant difference in the hazards ratio according to postoperative radiotherapy. There was no correlation between marker expression and prognosis. There was no association between marker expression and radioresistance or disease-specific survival. Therefore, HIF-1α, CA-IX, COX-2, Ki-67, and erythropoietin receptor are not suitable prognostic markers for tongue squamous cell carcinoma. Springer-Verlag Berlin Heidelberg, 2014 Tongue nationallicence Squamous cell carcinoma nationallicence Prognosis nationallicence Hypoxia-inducible factor-1α nationallicence Carbonic anhydrase-IX nationallicence Hwa Jeong Department of Otolaryngology-Head and Neck Surgery and Urology, School of Medicine, Gyeongsang National University, 90 Chilam-dong, 660-702, Jinju, South Korea aut Kwon Oh Department of Otolaryngology-Head and Neck Surgery and Urology, School of Medicine, Gyeongsang National University, 90 Chilam-dong, 660-702, Jinju, South Korea aut Park Jung Department of Otolaryngology-Head and Neck Surgery and Urology, School of Medicine, Gyeongsang National University, 90 Chilam-dong, 660-702, Jinju, South Korea aut Woo Seung Department of Otolaryngology-Head and Neck Surgery and Urology, School of Medicine, Gyeongsang National University, 90 Chilam-dong, 660-702, Jinju, South Korea aut Kim Jin Department of Otolaryngology-Head and Neck Surgery and Urology, School of Medicine, Gyeongsang National University, 90 Chilam-dong, 660-702, Jinju, South Korea aut Ko Gyung Department of Pathology and Pediatrics, Gyeongsang National University, Jinju, Korea aut Seo Ji Department of Pathology and Pediatrics, Gyeongsang National University, Jinju, Korea aut Kim Rock Dong-A University Hospital Regional Cardiocerebrovascular Center, Busan, Korea aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/10(2015-10-01), 2953-2959 0937-4477 272:10<2953 2015 272 405 https://doi.org/10.1007/s00405-014-3254-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-3254-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hwa Jeong Department of Otolaryngology-Head and Neck Surgery and Urology, School of Medicine, Gyeongsang National University, 90 Chilam-dong, 660-702, Jinju, South Korea aut NATIONALLICENCE 700 1- Kwon Oh Department of Otolaryngology-Head and Neck Surgery and Urology, School of Medicine, Gyeongsang National University, 90 Chilam-dong, 660-702, Jinju, South Korea aut NATIONALLICENCE 700 1- Park Jung Department of Otolaryngology-Head and Neck Surgery and Urology, School of Medicine, Gyeongsang National University, 90 Chilam-dong, 660-702, Jinju, South Korea aut NATIONALLICENCE 700 1- Woo Seung Department of Otolaryngology-Head and Neck Surgery and Urology, School of Medicine, Gyeongsang National University, 90 Chilam-dong, 660-702, Jinju, South Korea aut NATIONALLICENCE 700 1- Kim Jin Department of Otolaryngology-Head and Neck Surgery and Urology, School of Medicine, Gyeongsang National University, 90 Chilam-dong, 660-702, Jinju, South Korea aut NATIONALLICENCE 700 1- Ko Gyung Department of Pathology and Pediatrics, Gyeongsang National University, Jinju, Korea aut NATIONALLICENCE 700 1- Seo Ji Department of Pathology and Pediatrics, Gyeongsang National University, Jinju, Korea aut NATIONALLICENCE 700 1- Kim Rock Dong-A University Hospital Regional Cardiocerebrovascular Center, Busan, Korea aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/10(2015-10-01), 2953-2959 0937-4477 272:10<2953 2015 272 405