caa a22 4500 606185844 CHVBK 20210128100833.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s00405-014-3324-8 doi (NATIONALLICENCE)springer-10.1007/s00405-014-3324-8 Skin adnexal carcinoma of the head and neck: a retrospective study in a tertiary referral center [Elektronische Daten] [Hanneke Stam, Bart van de Wiel, W. Klop, Biljana Zupan-Kajcovski, Soe Janssens, M. Karakullukcu, Vincent van der Noort, Peter Lohuis] The objective of this study is to give more insight in the diagnosis, clinical course and therapy of skin adnexal carcinoma of the head and neck. Forty cases of skin adnexal carcinoma of the head and neck treated from 1977 to 2011 were identified by searching the hospitals cancer registration database. After pathology review by a pathologist specialized in skin cancer, 17 cases were excluded. A retrospective chart review of the remaining 23 patients was performed. Clinical course was recorded by endpoints including survival, loco-regional control and recurrence free survival. Prognostic factors considered for analysis were differentiation of the tumor and location of the tumor. Five-year overall survival (OS) was 78% (95% CI 61-100%). Five-year recurrence free survival (RFS) was 58% (95% CI 40-84%). Poor differentiation of the tumor significantly reduced OS (p=0.002) and RFS (p=0.01). Tumor location ‘face' demonstrated a significantly better survival than other tumor locations (p<0.001). Local recurrence occurred in five cases, regional metastasis was seen in seven patients, distant metastasis in three patients. Three cases with distant metastases died of disease. Based on the findings of this small group of patients in a tertiary referral center, we conclude that skin adnexal carcinoma is a very rare skin carcinoma that can behave locally aggressive but also has the potential for regional and distant metastasis. The recognition of skin adnexal carcinoma and subsequent wide excision in an early stage of the disease is of major importance for loco-regional control and survival. Springer-Verlag Berlin Heidelberg, 2014 Skin adnexal carcinoma nationallicence Head and neck nationallicence Clinical course nationallicence Therapy nationallicence Stam Hanneke Department of Head and Neck Oncology and Surgery, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands aut van de Wiel Bart Department of Pathology, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands aut Klop W. Department of Head and Neck Oncology and Surgery, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands aut Zupan-Kajcovski Biljana Department of Dermatology, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands aut Janssens Soe Department of Dermatology, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands aut Karakullukcu M. Department of Head and Neck Oncology and Surgery, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands aut van der Noort Vincent Department of Biometrics, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands aut Lohuis Peter Department of Head and Neck Oncology and Surgery, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/4(2015-04-01), 1001-1010 0937-4477 272:4<1001 2015 272 405 https://doi.org/10.1007/s00405-014-3324-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-3324-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Stam Hanneke Department of Head and Neck Oncology and Surgery, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- van de Wiel Bart Department of Pathology, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Klop W. Department of Head and Neck Oncology and Surgery, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Zupan-Kajcovski Biljana Department of Dermatology, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Janssens Soe Department of Dermatology, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Karakullukcu M. Department of Head and Neck Oncology and Surgery, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- van der Noort Vincent Department of Biometrics, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Lohuis Peter Department of Head and Neck Oncology and Surgery, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/4(2015-04-01), 1001-1010 0937-4477 272:4<1001 2015 272 405