caa a22 4500 606185976 CHVBK 20210128100834.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s00405-014-3145-9 doi (NATIONALLICENCE)springer-10.1007/s00405-014-3145-9 Association study between interleukin-12 receptor β1/β2 genes and allergic rhinitis in the Chinese Han population [Elektronische Daten] [Ping Wei, Wei Kou, Rong Sun, Guo-hua Hu, Di Hu, Jing Feng, Su-ling Hong, Hou-yong Kang] Interleukin-12 (IL-12) plays a key role in the protection against allergic reaction induced by allergen as well as the differentiation of T helper 1 cells in patients with allergic rhinitis (AR), exerting its biological effects through binding to specific IL-12 receptors (IL-12Rs) termed IL-12Rβ1 and IL-12Rβ2. In this study, we investigated the relationship between polymorphisms in the IL-12R gene and AR in the Chinese Han population. A total of 543 patients with AR and 749 normal controls were genotyped for IL-12Rβ1/rs438421, IL-12Rβ2/rs3790565, rs3790567, and rs6679356 using a PCR restriction fragment length polymorphism analysis. The association study of each polymorphism of the IL-12Rβ1 and IL-12Rβ2 gene and AR showed that a significantly increased prevalence of the homozygous rs438421 GG genotype and G allele appeared in the AR patients compared with healthy controls. A significantly decreased prevalence of AG in rs438421 in AR patients is compared with healthy controls. Our research demonstrated an important association between polymorphisms in IL-12Rβ1 and AR in the Chinese Han population. A strong association between rs438421 in a single nucleotide polymorphism of IL-12Rβ1 and AR was identified. Springer-Verlag Berlin Heidelberg, 2014 Allergic rhinitis nationallicence IL-12Rβ1 gene nationallicence IL-12Rβ2 gene nationallicence Single nucleotide polymorphism nationallicence Wei Ping Department of Otorhinolaryngology, The First Affiliated Hospital of Chongqing Medical University, 1# Yixueyuan Road, 400016, Chongqing, China aut Kou Wei Department of Otolaryngology, The Children's Hospital of Chongqing Medical University, Chongqing, China aut Sun Rong Department of Physical Examination, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China aut Hu Guo-hua Department of Otorhinolaryngology, The First Affiliated Hospital of Chongqing Medical University, 1# Yixueyuan Road, 400016, Chongqing, China aut Hu Di Department of Otorhinolaryngology, The First Affiliated Hospital of Chongqing Medical University, 1# Yixueyuan Road, 400016, Chongqing, China aut Feng Jing Department of Otorhinolaryngology, The First Affiliated Hospital of Chongqing Medical University, 1# Yixueyuan Road, 400016, Chongqing, China aut Hong Su-ling Department of Otorhinolaryngology, The First Affiliated Hospital of Chongqing Medical University, 1# Yixueyuan Road, 400016, Chongqing, China aut Kang Hou-yong Department of Otorhinolaryngology, The First Affiliated Hospital of Chongqing Medical University, 1# Yixueyuan Road, 400016, Chongqing, China aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/4(2015-04-01), 889-893 0937-4477 272:4<889 2015 272 405 https://doi.org/10.1007/s00405-014-3145-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-3145-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wei Ping Department of Otorhinolaryngology, The First Affiliated Hospital of Chongqing Medical University, 1# Yixueyuan Road, 400016, Chongqing, China aut NATIONALLICENCE 700 1- Kou Wei Department of Otolaryngology, The Children's Hospital of Chongqing Medical University, Chongqing, China aut NATIONALLICENCE 700 1- Sun Rong Department of Physical Examination, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China aut NATIONALLICENCE 700 1- Hu Guo-hua Department of Otorhinolaryngology, The First Affiliated Hospital of Chongqing Medical University, 1# Yixueyuan Road, 400016, Chongqing, China aut NATIONALLICENCE 700 1- Hu Di Department of Otorhinolaryngology, The First Affiliated Hospital of Chongqing Medical University, 1# Yixueyuan Road, 400016, Chongqing, China aut NATIONALLICENCE 700 1- Feng Jing Department of Otorhinolaryngology, The First Affiliated Hospital of Chongqing Medical University, 1# Yixueyuan Road, 400016, Chongqing, China aut NATIONALLICENCE 700 1- Hong Su-ling Department of Otorhinolaryngology, The First Affiliated Hospital of Chongqing Medical University, 1# Yixueyuan Road, 400016, Chongqing, China aut NATIONALLICENCE 700 1- Kang Hou-yong Department of Otorhinolaryngology, The First Affiliated Hospital of Chongqing Medical University, 1# Yixueyuan Road, 400016, Chongqing, China aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/4(2015-04-01), 889-893 0937-4477 272:4<889 2015 272 405