caa a22 4500 60618600X CHVBK 20210128100834.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s00405-014-3132-1 doi (NATIONALLICENCE)springer-10.1007/s00405-014-3132-1 Definitive radiotherapy for early-stage hypopharyngeal squamous cell carcinoma [Elektronische Daten] [Kaname Sato, Akira Kubota, Madoka Furukawa, Yousuke Kitani, Yuko Nakayama, Tetsuo Nonaka, Nobutaka Mizoguchi, Miho Shiomi] The present study analyzed the outcomes of patients with early-stage hypopharyngeal squamous cell carcinoma (HPSCC) treated with radical radiotherapy (RT) or concurrent chemoradiotherapy (CCRT). We retrospectively reviewed the clinical records of 33 patients with early-stage HPSCC who underwent RT or CCRT between January 1999 and December 2011. Of the 33 patients who were treated, 12 had Stage I and 21 had Stage II disease. Patients with Stage I were typically treated with RT, while patients with Stage II were treated with CCRT (concurrent chemotherapy: 5FU, cisplatin or TS-1). The median follow-up period was 81 months, ranging from 15 to 155 months. The 5-year overall survival rates, cause specific survival rates, locoregional control rates, and progression-free survival rates were 58, 75, 56, and 49%, respectively. Of the 33 patients, 51% experienced second primary malignancies. Esophageal carcinoma occurred in several cases, and was diagnosed either during screening after treatment for the second primary malignancy or simultaneously with the second primary malignancy. Advanced-stage second malignancies significantly influenced the survival of the patients and the control rate for HPSCC. Treatment emphasizing the quality of life after treatment is needed, if a poor prognosis is expected because of advanced-stage second primary malignancy. Springer-Verlag Berlin Heidelberg, 2014 Hypopharyngeal carcinoma nationallicence Radiotherapy nationallicence Concurrent chemoradiotherapy nationallicence Second primary malignancy nationallicence Sato Kaname Department of Head and Neck Surgery, Kanagawa Cancer Center, 2-3-2 Nakao, Asahi-ku, 241-8515, Yokohama, Kanagawa, Japan aut Kubota Akira Department of Head and Neck Surgery, Kanagawa Cancer Center, 2-3-2 Nakao, Asahi-ku, 241-8515, Yokohama, Kanagawa, Japan aut Furukawa Madoka Department of Head and Neck Surgery, Kanagawa Cancer Center, 2-3-2 Nakao, Asahi-ku, 241-8515, Yokohama, Kanagawa, Japan aut Kitani Yousuke Department of Head and Neck Surgery, Kanagawa Cancer Center, 2-3-2 Nakao, Asahi-ku, 241-8515, Yokohama, Kanagawa, Japan aut Nakayama Yuko Department of Radiation Oncology, Kanagawa Cancer Center, 2-3-2 Nakao, Asahi-ku, 241-8515, Yokohama, Kanagawa, Japan aut Nonaka Tetsuo Department of Radiation Oncology, Kanagawa Cancer Center, 2-3-2 Nakao, Asahi-ku, 241-8515, Yokohama, Kanagawa, Japan aut Mizoguchi Nobutaka Department of Radiation Oncology, Kanagawa Cancer Center, 2-3-2 Nakao, Asahi-ku, 241-8515, Yokohama, Kanagawa, Japan aut Shiomi Miho Department of Radiation Oncology, Kanagawa Cancer Center, 2-3-2 Nakao, Asahi-ku, 241-8515, Yokohama, Kanagawa, Japan aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/8(2015-08-01), 2001-2006 0937-4477 272:8<2001 2015 272 405 https://doi.org/10.1007/s00405-014-3132-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-3132-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sato Kaname Department of Head and Neck Surgery, Kanagawa Cancer Center, 2-3-2 Nakao, Asahi-ku, 241-8515, Yokohama, Kanagawa, Japan aut NATIONALLICENCE 700 1- Kubota Akira Department of Head and Neck Surgery, Kanagawa Cancer Center, 2-3-2 Nakao, Asahi-ku, 241-8515, Yokohama, Kanagawa, Japan aut NATIONALLICENCE 700 1- Furukawa Madoka Department of Head and Neck Surgery, Kanagawa Cancer Center, 2-3-2 Nakao, Asahi-ku, 241-8515, Yokohama, Kanagawa, Japan aut NATIONALLICENCE 700 1- Kitani Yousuke Department of Head and Neck Surgery, Kanagawa Cancer Center, 2-3-2 Nakao, Asahi-ku, 241-8515, Yokohama, Kanagawa, Japan aut NATIONALLICENCE 700 1- Nakayama Yuko Department of Radiation Oncology, Kanagawa Cancer Center, 2-3-2 Nakao, Asahi-ku, 241-8515, Yokohama, Kanagawa, Japan aut NATIONALLICENCE 700 1- Nonaka Tetsuo Department of Radiation Oncology, Kanagawa Cancer Center, 2-3-2 Nakao, Asahi-ku, 241-8515, Yokohama, Kanagawa, Japan aut NATIONALLICENCE 700 1- Mizoguchi Nobutaka Department of Radiation Oncology, Kanagawa Cancer Center, 2-3-2 Nakao, Asahi-ku, 241-8515, Yokohama, Kanagawa, Japan aut NATIONALLICENCE 700 1- Shiomi Miho Department of Radiation Oncology, Kanagawa Cancer Center, 2-3-2 Nakao, Asahi-ku, 241-8515, Yokohama, Kanagawa, Japan aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/8(2015-08-01), 2001-2006 0937-4477 272:8<2001 2015 272 405