caa a22 4500 606186042 CHVBK 20210128100834.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s00405-015-3528-6 doi (NATIONALLICENCE)springer-10.1007/s00405-015-3528-6 Association of history of allergies and influenza-like infections with laryngeal cancer in a case-control study [Elektronische Daten] [Filippos Filippidis, Stephen Schwartz, Nikolaus Becker, Gerhard Dyckhoff, Michael Kirschfink, Andreas Dietz, Heiko Becher, Heribert Ramroth] Prior studies suggest that history of allergy and infections early in life might be inversely associated with cancer. We explored the association between allergies, recent influenza infections and laryngeal cancer risk. We used data from a case-control study which included 229 cases of laryngeal cancer and 769 population controls matched for age and sex. History of a physician-diagnosed allergy, influenza-like infections in the past 5years, smoking, alcohol consumption and occupational exposure to carcinogens were self-reported. Allergies were classified into two groups (Type I and Type IV), according to the underlying immunologic mechanism. Conditional logistic regression models were fitted using laryngeal cancer as the outcome, adjusting for smoking, alcohol consumption and occupational exposure and stratified for age and sex. Having any allergy was not associated significantly with laryngeal cancer. Although Type I and Type IV allergies were non-significantly associated with laryngeal cancer, Type IV allergies showed a strong inverse association after adjusting for smoking and alcohol (OR 0.50, 95% CI 0.22-1.2). Participants who reported at least one influenza-like infection during the past 5years were significantly less likely to have laryngeal cancer (OR 0.57, 95% CI 0.39-0.81). After considering fever (≥38.5°C) as a criterion for influenza infection, the association between influenza infection and laryngeal cancer was even stronger (OR 0.29, 95% CI 0.13-0.63). We found no significant association between any allergy and laryngeal cancer, some indication of an inverse association between Type IV allergy and laryngeal cancer, whereas recent influenza infections were inversely associated with laryngeal cancer risk. Springer-Verlag Berlin Heidelberg, 2015 Laryngeal cancer nationallicence Influenza virus nationallicence Infection nationallicence Allergy nationallicence Filippidis Filippos Institute of Public Health, University of Heidelberg, Im Neuenheimer Feld 324, 69120, Heidelberg, Germany aut Schwartz Stephen Epidemiology Program, Fred Hutchinson Cancer Research Center, Seattle, USA aut Becker Nikolaus Division of Cancer Epidemiology, German Centre for Research on Cancer, Heidelberg, Germany aut Dyckhoff Gerhard Department of Otorhinolaryngology, Head and Neck Surgery, University of Heidelberg, Heidelberg, Germany aut Kirschfink Michael Institute for Immunology, University of Heidelberg, Heidelberg, Germany aut Dietz Andreas Department of Otorhinolaryngology, Head and Neck Surgery, University of Leipzig, Leipzig, Germany aut Becher Heiko Institute of Public Health, University of Heidelberg, Im Neuenheimer Feld 324, 69120, Heidelberg, Germany aut Ramroth Heribert Institute of Public Health, University of Heidelberg, Im Neuenheimer Feld 324, 69120, Heidelberg, Germany aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/8(2015-08-01), 2063-2069 0937-4477 272:8<2063 2015 272 405 https://doi.org/10.1007/s00405-015-3528-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-015-3528-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Filippidis Filippos Institute of Public Health, University of Heidelberg, Im Neuenheimer Feld 324, 69120, Heidelberg, Germany aut NATIONALLICENCE 700 1- Schwartz Stephen Epidemiology Program, Fred Hutchinson Cancer Research Center, Seattle, USA aut NATIONALLICENCE 700 1- Becker Nikolaus Division of Cancer Epidemiology, German Centre for Research on Cancer, Heidelberg, Germany aut NATIONALLICENCE 700 1- Dyckhoff Gerhard Department of Otorhinolaryngology, Head and Neck Surgery, University of Heidelberg, Heidelberg, Germany aut NATIONALLICENCE 700 1- Kirschfink Michael Institute for Immunology, University of Heidelberg, Heidelberg, Germany aut NATIONALLICENCE 700 1- Dietz Andreas Department of Otorhinolaryngology, Head and Neck Surgery, University of Leipzig, Leipzig, Germany aut NATIONALLICENCE 700 1- Becher Heiko Institute of Public Health, University of Heidelberg, Im Neuenheimer Feld 324, 69120, Heidelberg, Germany aut NATIONALLICENCE 700 1- Ramroth Heribert Institute of Public Health, University of Heidelberg, Im Neuenheimer Feld 324, 69120, Heidelberg, Germany aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/8(2015-08-01), 2063-2069 0937-4477 272:8<2063 2015 272 405