caa a22 4500 60618614X CHVBK 20210128100835.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s00405-014-3278-x doi (NATIONALLICENCE)springer-10.1007/s00405-014-3278-x Evaluation of post-traumatic anosmia with MRI and chemosensory ERPs [Elektronische Daten] [Xutao Miao, Ling Yang, Hua Gu, Yuanyuan Ren, Guowei Chen, Jia Liu, Yongxiang Wei] Magnetic resonance imaging (MRI) and chemosensory event-related potentials (ERPs) are important methods to evaluate olfactory function, but there is lack of study to explore the application of MRI and chemosensory ERPs in the patients with traumatic anosmia. The data of 26 post-traumatic anosmic patients and 21 healthy controls were retrospectively surveyed; olfaction and olfactory pathway of all participants were measured clinically using the T&T olfactometer, the Sniffin' Sticks, chemosensory ERPs and MRI. All patients were anosmic based on complaints and clinical examinations. In five patients, the olfactory bulb volume was significantly lower than control group. In 18 patients, the olfactory sulcus (OS) depth was similar to control group, but all the participants had a deeper right OS (right=7.79±1.31, left=7.06±1.44, p<0.01). Olfactory ERPs (oERPs) could be evoked in 17 patients, but these signals showed longer latencies and lower amplitude than controls in the N1 (latency p<0.05, amplitude p<0.01) and P2 (latency p<0.01, amplitude p<0.05) waves. Nine traumatic anosmic patients had no identifiable oERPs; most of them had olfactory center injury. Trigeminal ERPs were detected in all anosmic patients and controls; patients had longer latencies for N1 (p<0.05) and P2 (p<0.05) waves, while there was no similar change in amplitude. Older subjects had smaller OB volume and OS depth. Closed head injury could induce anosmia; the severity extent, injury site and subsequent consciousness are related to the olfaction. oERP is the gold standard for olfactory subjective examination; MRI could indicate the lesions on the olfactory pathway and reflect the possibility of detectable oERPs. Springer-Verlag Berlin Heidelberg, 2014 Olfactory disorder nationallicence Head injury, closed nationallicence Event-related potentials (ERPs) nationallicence MRI nationallicence Anosmia nationallicence Miao Xutao Department of Otolaryngology Head and Neck Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China aut Yang Ling Center Laboratory, Beijing Tongren Hospital, Capital Medical University, Beijing, China aut Gu Hua Department of Radiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China aut Ren Yuanyuan Department of Otolaryngology Head and Neck Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China aut Chen Guowei Department of Otolaryngology Head and Neck Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China aut Liu Jia Department of Otolaryngology Head and Neck Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China aut Wei Yongxiang Department of Otolaryngology Head and Neck Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/8(2015-08-01), 1945-1953 0937-4477 272:8<1945 2015 272 405 https://doi.org/10.1007/s00405-014-3278-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-3278-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Miao Xutao Department of Otolaryngology Head and Neck Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China aut NATIONALLICENCE 700 1- Yang Ling Center Laboratory, Beijing Tongren Hospital, Capital Medical University, Beijing, China aut NATIONALLICENCE 700 1- Gu Hua Department of Radiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China aut NATIONALLICENCE 700 1- Ren Yuanyuan Department of Otolaryngology Head and Neck Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China aut NATIONALLICENCE 700 1- Chen Guowei Department of Otolaryngology Head and Neck Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China aut NATIONALLICENCE 700 1- Liu Jia Department of Otolaryngology Head and Neck Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China aut NATIONALLICENCE 700 1- Wei Yongxiang Department of Otolaryngology Head and Neck Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/8(2015-08-01), 1945-1953 0937-4477 272:8<1945 2015 272 405