caa a22 4500 606186166 CHVBK 20210128100835.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s00405-014-3269-y doi (NATIONALLICENCE)springer-10.1007/s00405-014-3269-y The effectiveness topical amphotericin B in the management of chronic rhinosinusitis: a meta-analysis [Elektronische Daten] [Tianqi Wang, Jinfei Su, Yanjun Feng] Chronic rhinosinusitis (CRS) is believed to be the result of an exaggerated reaction to fungi in the nasal mucosa, and topical amphotericin B (AMB) is a commonly used treatment. The purpose of this study was to perform a meta-analysis of high-quality comparative studies to examine the efficacy of topical AMB for the treatment of CRS. A search was conducted of Medline, Cochrane, EMBASE, and ISI Web of Knowledge until December 31, 2013 using combinations of the search terms chronic rhinosinusitis, human, treatment, antibiotics, nasal irrigation, nebulized, nasal lavage, sinonasal rinses, and antimicrobials. Inclusion criteria were (1) comparative studies, (2) a diagnosis of CRS or chronic sinusitis, and (3) the intervention was a topical antifungal. The primary outcome measure was quality of life (QOL), and the secondary was nasal endoscopy score. Of 235 article initially identified, five randomized controlled trials were included in the meta-analysis. Analysis of four studies with complete QOL data found no difference between treatment and placebo groups [standard difference in means 0.78, 95% confidence interval (CI) −0.25 to 1.81, P=0.138]. Analysis of four studies with complete nasal endoscopy score data found no difference between the treatment and placebo groups (standard difference in means 0.34, 95% CI −0.08 to 0.76, P=0.117). AMB is not more effective than placebo in improving QOL or nasal endoscopy scores in patients with CRS. Springer-Verlag Berlin Heidelberg, 2014 Amphotericin B nationallicence Chronic rhinosinusitis nationallicence Eosinophilic infiltration nationallicence Nasal mucosa nationallicence Meta-analysis nationallicence Wang Tianqi Department of Otorhinolaryngology, Head and Neck Surgery Capital Medical University Xuanwu Hospital, No. 45 Changchunjie Street, Xicheng District, 100053, Beijing, China aut Su Jinfei Department of Otorhinolaryngology, Head and Neck Surgery Capital Medical University Xuanwu Hospital, No. 45 Changchunjie Street, Xicheng District, 100053, Beijing, China aut Feng Yanjun Department of Otorhinolaryngology, Head and Neck Surgery Capital Medical University Xuanwu Hospital, No. 45 Changchunjie Street, Xicheng District, 100053, Beijing, China aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/8(2015-08-01), 1923-1929 0937-4477 272:8<1923 2015 272 405 https://doi.org/10.1007/s00405-014-3269-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-3269-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wang Tianqi Department of Otorhinolaryngology, Head and Neck Surgery Capital Medical University Xuanwu Hospital, No. 45 Changchunjie Street, Xicheng District, 100053, Beijing, China aut NATIONALLICENCE 700 1- Su Jinfei Department of Otorhinolaryngology, Head and Neck Surgery Capital Medical University Xuanwu Hospital, No. 45 Changchunjie Street, Xicheng District, 100053, Beijing, China aut NATIONALLICENCE 700 1- Feng Yanjun Department of Otorhinolaryngology, Head and Neck Surgery Capital Medical University Xuanwu Hospital, No. 45 Changchunjie Street, Xicheng District, 100053, Beijing, China aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/8(2015-08-01), 1923-1929 0937-4477 272:8<1923 2015 272 405