caa a22 4500 606186174 CHVBK 20210128100835.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s00405-014-3140-1 doi (NATIONALLICENCE)springer-10.1007/s00405-014-3140-1 Treatment of base of tongue cancer, stage III and stage IV with primary surgery: survival and functional outcomes [Elektronische Daten] [Khaled Al-Qahtani, Jen Rieger, Jeffery Harris, Alex Mlynarek, David Williams, Tahera Islam, Hadi Seikaly] This study examines functional outcome (speech and swallowing), survival, and disease control in patients receiving an intensified treatment regimen with primary aggressive surgery, and postoperative radiotherapy or postoperative concomitant chemoradiotherapy, for previously untreated, resectable, stage III and IV squamous cell carcinoma (SCC) of the tongue base. Sixty-six consecutive patients treated from June 1997 to June 2006 were followed prospectively through the Multidisciplinary Head and Neck Surgery Reconstruction Clinic. Speech and swallowing data were gathered at four evaluation times during the first year. Speech assessment was conducted by PERCI, Nasometer, and C-AIDS and swallowing assessment by Modified barium swallow, Diet survey and G-tube. Also, the overall survival, disease-specific survival and loco regional control were measured. The average age of the patients was 56.8, 85% male and 15% female. All patients had primary surgical resection and 83% received postoperative radiotherapy and 17% chemoradiation therapy. Overall survival at 3years was 80.3% and 5years 52.2%. Disease-specific survival at 3years was 86.7% and 5years was 77.5%. Local control was 94%. Distal metastasis and second primary were found to be 7.5% each. Primary surgical treatment of advanced BOT cancer offers excellent functional outcome, local control and disease-specific survival. Springer-Verlag Berlin Heidelberg, 2014 Oropharynx nationallicence Base of tongue nationallicence Head and neck cancer nationallicence Micro vascular reconstruction nationallicence Speech nationallicence Swallowing nationallicence Local control and disease-specific survival nationallicence Al-Qahtani Khaled Craniofacial Osseointegration and Maxillofacial Prosthetic Rehabilitation Unit (COMPRU), Misericordia Hospital, Caritas Health Group, Edmonton, AB, Canada aut Rieger Jen Craniofacial Osseointegration and Maxillofacial Prosthetic Rehabilitation Unit (COMPRU), Misericordia Hospital, Caritas Health Group, Edmonton, AB, Canada aut Harris Jeffery Craniofacial Osseointegration and Maxillofacial Prosthetic Rehabilitation Unit (COMPRU), Misericordia Hospital, Caritas Health Group, Edmonton, AB, Canada aut Mlynarek Alex Division of Otolaryngology-Head and Neck Surgery, University of Alberta, Edmonton, AB, Canada aut Williams David Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada aut Islam Tahera College of Medicine and Research Center, King Saud University, Riyadh, Kingdom of Saudi Arabia aut Seikaly Hadi Craniofacial Osseointegration and Maxillofacial Prosthetic Rehabilitation Unit (COMPRU), Misericordia Hospital, Caritas Health Group, Edmonton, AB, Canada aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/8(2015-08-01), 2027-2033 0937-4477 272:8<2027 2015 272 405 https://doi.org/10.1007/s00405-014-3140-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-3140-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Al-Qahtani Khaled Craniofacial Osseointegration and Maxillofacial Prosthetic Rehabilitation Unit (COMPRU), Misericordia Hospital, Caritas Health Group, Edmonton, AB, Canada aut NATIONALLICENCE 700 1- Rieger Jen Craniofacial Osseointegration and Maxillofacial Prosthetic Rehabilitation Unit (COMPRU), Misericordia Hospital, Caritas Health Group, Edmonton, AB, Canada aut NATIONALLICENCE 700 1- Harris Jeffery Craniofacial Osseointegration and Maxillofacial Prosthetic Rehabilitation Unit (COMPRU), Misericordia Hospital, Caritas Health Group, Edmonton, AB, Canada aut NATIONALLICENCE 700 1- Mlynarek Alex Division of Otolaryngology-Head and Neck Surgery, University of Alberta, Edmonton, AB, Canada aut NATIONALLICENCE 700 1- Williams David Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada aut NATIONALLICENCE 700 1- Islam Tahera College of Medicine and Research Center, King Saud University, Riyadh, Kingdom of Saudi Arabia aut NATIONALLICENCE 700 1- Seikaly Hadi Craniofacial Osseointegration and Maxillofacial Prosthetic Rehabilitation Unit (COMPRU), Misericordia Hospital, Caritas Health Group, Edmonton, AB, Canada aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/8(2015-08-01), 2027-2033 0937-4477 272:8<2027 2015 272 405