caa a22 4500 606186190 CHVBK 20210128100835.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s00405-014-3161-9 doi (NATIONALLICENCE)springer-10.1007/s00405-014-3161-9 A two-decade experience of head and neck paragangliomas in a whole population-based single centre cohort [Elektronische Daten] [T. Anttila, V. Häyry, T. Nicoli, J. Hagström, K. Aittomäki, P. Vikatmaa, M. Niemelä, K. Saarilahti, A. Mäkitie, L. Bäck] Paragangliomas are rare neuroendocrine tumours arising from neural crest-derived tissue. In the head and neck region typical locations are the carotid bifurcation, vagal nerve or jugulotympanic region. Paragangliomas are normally benign, and malignant transformation is rare. During the past decade the understanding of the genetic and molecular aetiology has had an important clinical impact on the management of PGs. This is a retrospective review of all histologically verified paragangliomas diagnosed and managed at an academic tertiary care referral centre between 1990 and 2010. Data on age, sex, symptoms, tumour location, management and follow-up were recorded. There were 64 patients with 74 tumours. Thirty-six per cent of the tumours were located in the carotid body region, 48% in the jugulotympanic region and 15% in the vagal nerve. One tumour was located in the dorsal neck. Most (95%) of the patients were treated primarily with surgery and with curative intent. Definitive radiation therapy was primarily given to two patients. Recurrent or residual tumours were treated with surgery in three patients and with radiation therapy in nine patients. The typical long-term post-operative sequel was vocal cord paralysis. Local recurrence was found in 6% of patients. Symptoms and findings related to paragangliomas are variable and management should be individualized. Surgery remains the primary choice of the current treatment options, but often is challenging and warrants a multidisciplinary approach. We present an algorithm on the management of head and neck paragangliomas based on current knowledge. Springer-Verlag Berlin Heidelberg, 2014 Head and neck neoplasms nationallicence Paraganglioma nationallicence Surgery nationallicence Genetic testing nationallicence Mutation nationallicence Succinate dehydrogenase nationallicence Anttila T. Department of Otorhinolaryngology-Head and Neck Surgery, Helsinki University Central Hospital and University of Helsinki, P.O. Box 220, 00029 HUS, Helsinki, Finland aut Häyry V. Department of Otorhinolaryngology-Head and Neck Surgery, Helsinki University Central Hospital and University of Helsinki, P.O. Box 220, 00029 HUS, Helsinki, Finland aut Nicoli T. Department of Otorhinolaryngology-Head and Neck Surgery, Helsinki University Central Hospital and University of Helsinki, P.O. Box 220, 00029 HUS, Helsinki, Finland aut Hagström J. Department of Pathology and Oral Pathology, Haartman Institute and HUSLAB, University of Helsinki and Helsinki University Central Hospital, P.O. Box 21, 00014, Helsinki, Finland aut Aittomäki K. Department of Clinical Genetics, HUSLAB, Helsinki University Central Hospital, P.O. Box 400, 00029 HUS, Helsinki, Finland aut Vikatmaa P. Department of Vascular Surgery, Helsinki University Central Hospital, P.O. Box 340, 00029 HUS, Helsinki, Finland aut Niemelä M. Department of Neurosurgery, Helsinki University Central Hospital, P.O. Box 266, 00029 HUS, Helsinki, Finland aut Saarilahti K. Department of Oncology, Helsinki University Central Hospital, P.O. Box 180, 00029 HUS, Helsinki, Finland aut Mäkitie A. Department of Otorhinolaryngology-Head and Neck Surgery, Helsinki University Central Hospital and University of Helsinki, P.O. Box 220, 00029 HUS, Helsinki, Finland aut Bäck L. Department of Otorhinolaryngology-Head and Neck Surgery, Helsinki University Central Hospital and University of Helsinki, P.O. Box 220, 00029 HUS, Helsinki, Finland aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/8(2015-08-01), 2045-2053 0937-4477 272:8<2045 2015 272 405 https://doi.org/10.1007/s00405-014-3161-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-3161-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Anttila T. Department of Otorhinolaryngology-Head and Neck Surgery, Helsinki University Central Hospital and University of Helsinki, P.O. Box 220, 00029 HUS, Helsinki, Finland aut NATIONALLICENCE 700 1- Häyry V. Department of Otorhinolaryngology-Head and Neck Surgery, Helsinki University Central Hospital and University of Helsinki, P.O. Box 220, 00029 HUS, Helsinki, Finland aut NATIONALLICENCE 700 1- Nicoli T. Department of Otorhinolaryngology-Head and Neck Surgery, Helsinki University Central Hospital and University of Helsinki, P.O. Box 220, 00029 HUS, Helsinki, Finland aut NATIONALLICENCE 700 1- Hagström J. Department of Pathology and Oral Pathology, Haartman Institute and HUSLAB, University of Helsinki and Helsinki University Central Hospital, P.O. Box 21, 00014, Helsinki, Finland aut NATIONALLICENCE 700 1- Aittomäki K. Department of Clinical Genetics, HUSLAB, Helsinki University Central Hospital, P.O. Box 400, 00029 HUS, Helsinki, Finland aut NATIONALLICENCE 700 1- Vikatmaa P. Department of Vascular Surgery, Helsinki University Central Hospital, P.O. Box 340, 00029 HUS, Helsinki, Finland aut NATIONALLICENCE 700 1- Niemelä M. Department of Neurosurgery, Helsinki University Central Hospital, P.O. Box 266, 00029 HUS, Helsinki, Finland aut NATIONALLICENCE 700 1- Saarilahti K. Department of Oncology, Helsinki University Central Hospital, P.O. Box 180, 00029 HUS, Helsinki, Finland aut NATIONALLICENCE 700 1- Mäkitie A. Department of Otorhinolaryngology-Head and Neck Surgery, Helsinki University Central Hospital and University of Helsinki, P.O. Box 220, 00029 HUS, Helsinki, Finland aut NATIONALLICENCE 700 1- Bäck L. Department of Otorhinolaryngology-Head and Neck Surgery, Helsinki University Central Hospital and University of Helsinki, P.O. Box 220, 00029 HUS, Helsinki, Finland aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/8(2015-08-01), 2045-2053 0937-4477 272:8<2045 2015 272 405