caa a22 4500 606186263 CHVBK 20210128100835.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s00405-014-3290-1 doi (NATIONALLICENCE)springer-10.1007/s00405-014-3290-1 Correlation analysis of STAT3 and VEGF expression and eosinophil infiltration in nasal polyps [Elektronische Daten] [Qingsong Cao, Tao Zhang, Jie Zhang] The expression and distribution of signal transducer and activator of transcription 3 (STAT3), phosphorylated STAT3 (p-STAT3), and vascular endothelial growth factor (VEGF), as well as eosinophil infiltration in nasal polyps was detected to examine their roles and correlations in the nasal polyp pathogenesis. Using the streptavidin-biotin-peroxidase (SP) method, immunohistochemistry was performed on conventional paraffin sections of 30 surgery-resected polypous specimens and 10 inferior turbinate tissues that were resected during nasal septum deflection correction to detect the expression of STAT3, p-STAT3, and VEGF, as well as eosinophil infiltration. The rates of STAT3-, p-STAT3-, and VEGF-positive expression in the mucosal epithelium and glands of nasal polyps were 66.67, 56.67, and 76.67%, respectively, values that were significantly higher than those in the inferior turbinate group. The number of eosinophils in the nasal polyps was significantly higher than in the inferior turbinate group. Expression of p-STAT3 and VEGF in nasal polyps and eosinophil infiltration was increased significantly and positively correlated, indicating that VEGF and eosinophil infiltration might be regulated by p-STAT3. Therefore, the expression of STAT3, p-STAT3, and VEGF, and eosinophil infiltration might be important factors in nasal polyp pathogenesis. Springer-Verlag Berlin Heidelberg, 2014 Nasal polyps nationallicence Signal transducers and activators of transcription 3 nationallicence Vascular endothelial growth factor nationallicence Eosinophils nationallicence Cao Qingsong Department of Otorhinolaryngology, The First Affiliated Hospital, Jinan University, 510630, Guangzhou, China aut Zhang Tao Department of Otorhinolaryngology, The First Affiliated Hospital, Jinan University, 510630, Guangzhou, China aut Zhang Jie VIP Ward, The First Affiliated Hospital, Jinan University, 510630, Guangzhou, China aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/8(2015-08-01), 1955-1960 0937-4477 272:8<1955 2015 272 405 https://doi.org/10.1007/s00405-014-3290-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-3290-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cao Qingsong Department of Otorhinolaryngology, The First Affiliated Hospital, Jinan University, 510630, Guangzhou, China aut NATIONALLICENCE 700 1- Zhang Tao Department of Otorhinolaryngology, The First Affiliated Hospital, Jinan University, 510630, Guangzhou, China aut NATIONALLICENCE 700 1- Zhang Jie VIP Ward, The First Affiliated Hospital, Jinan University, 510630, Guangzhou, China aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/8(2015-08-01), 1955-1960 0937-4477 272:8<1955 2015 272 405