caa a22 4500 606186298 CHVBK 20210128100835.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s00405-014-2992-8 doi (NATIONALLICENCE)springer-10.1007/s00405-014-2992-8 Uni- and multivariate models for investigating potential prognostic factors in idiopathic sudden sensorineural hearing loss [Elektronische Daten] [Marco Lionello, Claudia Staffieri, Stefano Breda, Chiara Turato, Luciano Giacomelli, Paola Magnavita, Cosimo de Filippis, Alberto Staffieri, Gino Marioni] With a worldwide incidence estimated at 8-15 per 100,000 population a year, idiopathic sudden sensorineural hearing loss (ISSHL) is a common clinical finding for otologists. There is a shortage of information on the clinical factors capable of predicting hearing recovery and response to therapy. The aim of the present study was to retrospectively investigate the prognostic value of clinical variables in relation to hearing recovery, in a cohort of 117 consecutive patients with ISSHL. Clinical parameters (signs, symptoms, comorbidities and treatments) and audiometric data were analyzed with univariate and multivariate statistical approaches for prognostic purposes to identify any correlation with hearing recovery, also expressed according to the Wilson criteria. Univariate analysis showed that age and hypertension were significantly related to hearing outcome (p=0.004 and p=0.015, respectively). Elderly patients and those with hypertension were at higher risk of experiencing no hearing recovery (OR=3.25 and OR=2.89, respectively). Age was an independent prognostic factor on multivariate analysis (p=0.007). Tinnitus as a presenting symptom showed a trend towards an association with hearing recovery (p=0.07). The treatment regimen, the time elapsing between the onset of symptoms and the start of therapy (p=0.34), and the duration of the treatment (p=0.83) were unrelated to recovery on univariate analysis. Among the parameters considered, only age was significantly and independently related to hearing outcome. There is a need for well-designed, randomized clinical trials to enable an evidence-based protocol to be developed for the treatment of ISSHL. Springer-Verlag Berlin Heidelberg, 2014 Sudden hearing loss nationallicence Sensorineural nationallicence Idiopathic nationallicence Recovery nationallicence Age nationallicence Hypertension nationallicence Lionello Marco Otolaryngology Section, Department of Neurosciences, University of Padua, Padua, Italy aut Staffieri Claudia Otolaryngology Section, Department of Neurosciences, Treviso Hospital, University of Padua, Treviso, Italy aut Breda Stefano Otolaryngology Section, Department of Neurosciences, University of Padua, Padua, Italy aut Turato Chiara Otolaryngology Section, Department of Neurosciences, University of Padua, Padua, Italy aut Giacomelli Luciano Department of Medicine DIMED, University of Padua, Padua, Italy aut Magnavita Paola Otolaryngology Section, Department of Neurosciences, University of Padua, Padua, Italy aut de Filippis Cosimo Otolaryngology Section, Department of Neurosciences, University of Padua, Padua, Italy aut Staffieri Alberto Otolaryngology Section, Department of Neurosciences, University of Padua, Padua, Italy aut Marioni Gino Otolaryngology Section, Department of Neurosciences, University of Padua, Padua, Italy aut European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/8(2015-08-01), 1899-1906 0937-4477 272:8<1899 2015 272 405 https://doi.org/10.1007/s00405-014-2992-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00405-014-2992-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lionello Marco Otolaryngology Section, Department of Neurosciences, University of Padua, Padua, Italy aut NATIONALLICENCE 700 1- Staffieri Claudia Otolaryngology Section, Department of Neurosciences, Treviso Hospital, University of Padua, Treviso, Italy aut NATIONALLICENCE 700 1- Breda Stefano Otolaryngology Section, Department of Neurosciences, University of Padua, Padua, Italy aut NATIONALLICENCE 700 1- Turato Chiara Otolaryngology Section, Department of Neurosciences, University of Padua, Padua, Italy aut NATIONALLICENCE 700 1- Giacomelli Luciano Department of Medicine DIMED, University of Padua, Padua, Italy aut NATIONALLICENCE 700 1- Magnavita Paola Otolaryngology Section, Department of Neurosciences, University of Padua, Padua, Italy aut NATIONALLICENCE 700 1- de Filippis Cosimo Otolaryngology Section, Department of Neurosciences, University of Padua, Padua, Italy aut NATIONALLICENCE 700 1- Staffieri Alberto Otolaryngology Section, Department of Neurosciences, University of Padua, Padua, Italy aut NATIONALLICENCE 700 1- Marioni Gino Otolaryngology Section, Department of Neurosciences, University of Padua, Padua, Italy aut NATIONALLICENCE 773 0- European Archives of Oto-Rhino-Laryngology Springer Berlin Heidelberg 272/8(2015-08-01), 1899-1906 0937-4477 272:8<1899 2015 272 405